Plasma antioxidant vitamins and carotenoids and age-related cataract

Galé, Catharine R.; Hall, Nigel F; Phillips, David I. W.; Martyn, Christopher

doi:10.1016/s0161-6420(01)00833-8

Cited by 140 publications

(73 citation statements)

References 28 publications

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“…54 In the present case-control studies we did not find associations with dietary vitamin C. In a study in the north of England the risk of nuclear cataract, after adjustment, was lowest in people with the highest plasma concentrations of alphacarotene or beta-carotene; cortical cataract risk was lowest in people with the highest plasma concentrations of lycopene and PSC cataract risk was lowest in those with higher concentrations of lutein. 55 In the present study, multivariable logistic regression incorporating all significant univariable results confirmed at a 5% probability level that the number of 'any' analgesics used in the past year and the total lifetime sunlight exposure were significant independent risk factors for waterclefts, with higher exposures to each conferring greater risk. While this concurs with an accepted risk of sunlight exposure for cortical cataract, 39 previous studies have been divided on the question of risk from analgesic use.…”

Section: Discussionsupporting

confidence: 72%

Risk factors for cataract subtypes waterclefts and retrodots: two case–control studies

Durant

Frost

Trivella

et al. 2005

Eye

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Waterclefts and retrodots are independently associated with visual impairment, yet a review identified no data on risk factors. Purpose To investigate risk factors for these two human lens cataract subtypes. Method Two nested case-control studies: The host study comprised 1078 subjects (Z55 years) attending the Somerset and Avon Eye Study (SAES). In total, 197 watercleft cases (ZOxford grade 0.2 in either eye) and 199 retrodot cases (ZOxford grade 1.0 in either eye) were individually age/gender matched to controls. Detailed ophthalmic and potential risk factor data were collected, including body mass index (BMI), smoking, alcohol, diabetes, hypertension, analgesics, vitamin supplementation, nutrition, sunlight exposure, dehydration, hormonal (women), blood lipids, glucose, urea, creatinine, uric acid, and vitamin levels. Results For waterclefts, univariable analysis identified BMI, alcohol intake, vitamin status, sunlight, urea, creatinine, and uric acid as possible risk factors. Multivariable analysis identified two independent associations. Total number of 'any' analgesics in the previous year: adjusted Po0.01 (U-shaped risk profile, unadjusted high vs medium use ( ¼ reference) OR 2.39, 95% CI 1.35-4.26 with medium use vs none ( ¼ reference) OR 0.43, 95% CI 0.26-0.72); total sunlight: adjusted P ¼ 0.03 (unadjusted highest exposure vs lowest ( ¼ reference) OR 3.25, 95% CI 1.11-9.50). For retrodots, univariable analysis identified alcohol, HRT, and lipids. Multivariable analysis identified two independent associations. Mean number of alcohol units consumed per month, adjusted P ¼ 0.02 and HDL cholesterol levels, adjusted P ¼ 0.02 (unadjusted ORs NS both).Conclusion This is the first available published information on risk factors for the human cataractous lens features waterclefts and retrodots.

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Section: Discussionsupporting

confidence: 72%

Risk factors for cataract subtypes waterclefts and retrodots: two case–control studies

Durant

Frost

Trivella

et al. 2005

Eye

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“…These carotenoids have a dual ocular function, contributing to the filtration of ultraviolet rays and exerting an antioxidant function against ROS produced by this radiation. Observational studies have shown an inverse relationship between the intake of lutein and the presence of age-related macular degeneration (Mares-Perlman et al, 2001), cataracts (Olmedilla et al, 2003;Gale et al, 2014;Liu et al, 2014) and retinitis pigmentosa (Beatty et al, 2000). Lutein antioxidant activity has been biochemically reported in in vitro studies using human erythrocytes (Vijayapadma et al, 2014) and human retinal pigment epithelial cells .…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo effects of lutein against cisplatin-induced ototoxicity

Fidalgo

Saldaña²,

Trinidad

et al. 2016

Experimental and Toxicologic Pathology

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Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in: Experimental and Toxicologic Pathology 68.4 (2016): 197-204 A B S T R A C TIntroduction: Cisplatin is a commonly prescribed drug that produces ototoxicity as a side effect. Lutein is a carotenoid with antioxidant and anti-inflammatory properties previously tested for eye, heart and skin diseases but not evaluated to date in ear diseases.Aim: To evaluate the protective effects of lutein on HEI-OC1 auditory cell line and in a Wistar rat model of cisplatin ototoxicity.Materials and Methods: In vitro study: Culture HEI-OC1 cells were exposed to lutein (2.5-100 mM) and to 25 mM cisplatin for 24 h. In vivo study: Twenty eight female Wistar rats were randomized into three groups. Group A (n = 8) received intratympanic lutein (0.03 mL) (1 mg/mL) in the right ear and saline solution in the left one to determine the toxicity of lutein. Group B (n = 8) received also intraperitoneal cisplatin (10 mg/kg) to test the efficacy of lutein against cisplatin ototoxicity. Group C (n = 12) received intratympanic lutein (0.03 mL) (1 mg/mL) to quantify lutein in cochlear fluids (30 min,1 h and 5 days after treatment). Hearing function was evaluated by means of Auditory Steady-State Responses before the procedure and 5 days after (groups A and B). Morphological changes were studied by confocal laser scanning microscopy.Results: In vitro study: Lutein significantly reduced the cisplatin-induced cytotoxicity in the HEI-OC1 cells when they were pre-treated with lutein concentrations of 60 and 80 mM. In vivo study: Intratympaniclutein (1 mg/mL) application showed no ototoxic effects. However it did not achieve protective effect against cisplatin-induced ototoxicity in Wistar rats.Conclusions: Although lutein has shown beneficial effects in other pathologies, the present study only obtained protection against cisplatin ototoxicity in culture cells, but not in the in vivo model. The large molecule size, the low dose administered, and restriction to diffusion in the inner ear could account for this negative result

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“…Serum tocopherol levels and the risk of age-related cataract A forest plot of the seventeen included studies from fourteen articles (11)(12)(13)18,41,42,46,(48)(49)(50)(51)(54)(55)(56) with 17 194 participants and 4179 cases is shown in Fig. 4.…”

Section: Supplemental Vitamin E Intake and Risk Of Age-related Cataractmentioning

confidence: 99%

Vitamin E and risk of age-related cataract: a meta-analysis

Zhang¹,

Jiang²,

Xie³

et al. 2015

Public Health Nutr.

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Objective: We conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract (ARC). Design: The fixed-or random-effect model was selected based on heterogeneity. Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Begg's test. The dose-response relationship was assessed by a restricted cubic spline model. Setting: Relevant studies were identified by a search of PubMed and the Cochrane Library to May 2014, without language restrictions. Subjects: Studies involved samples of people of all ages. Results: Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95 % CI 0·58, 0·92), 0·86 (95 % CI 0·75, 0·99) and 0·77 (95 % CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk = 0·92; 95 % CI 0·78, 1·07). The findings from dose-response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk = 0·94; 95 % CI 0·90, 0·97). Conclusions: The findings of the meta-analysis indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and high level of serum tocopherol might be significantly associated with reduced ARC risk.

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Plasma antioxidant vitamins and carotenoids and age-related cataract

Cited by 140 publications

References 28 publications

Risk factors for cataract subtypes waterclefts and retrodots: two case–control studies

Risk factors for cataract subtypes waterclefts and retrodots: two case–control studies

In vitro and in vivo effects of lutein against cisplatin-induced ototoxicity

Vitamin E and risk of age-related cataract: a meta-analysis

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