Plasma antioxidant status and motor features in<i>de novo</i>Chinese Parkinson's disease patients

Yuan, Yongsheng; Tong, Qingyi; Zhang, Li; Jiang, Shaojun; Zhang, Rui; Zhang, Shu; Xu, Qinrong; Li, Daqian; Zhou, Xiujuan; Ding, Jian; Zhang, Kezhong

doi:10.3109/00207454.2015.1054031

Cited by 11 publications

(5 citation statements)

References 36 publications

(65 reference statements)

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“…Although clinical data were inconsistent for individual biomarkers and across studies, a meta-analysis included 25 studies with 2654 individuals demonstrated that PD patients had elevated levels of blood inflammatory cytokine interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), IL-1β, IL-2, IL-10, C-reactive protein (CRP) and regulated on activation, normal T cell expressed and secreted (RANTES) compared with healthy control (HC) subjects, thus clarifying the peripheral blood inflammatory cytokine profile in patients with PD (Qin et al, 2016b ). More clinical studies showed increased levels of circulating oxidative stress markers and decreased levels of antioxidants in PD patients, especially in peripheral blood (Kalra et al, 1992 ; Alimonti et al, 2007 ; Chen et al, 2009 ; Vinish et al, 2011 ; Medeiros et al, 2016 ; Yuan et al, 2016 ). However, significant heterogeneity among studies and negative results have been observed for the imbalance of oxidative stress pathway.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Parkinson's Disease: A Systematic Review and Meta-Analysis

Wei

et al. 2018

Front. Mol. Neurosci.

227

165

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Oxidative stress has been suggested to play a key role in Parkinson's disease, but inconsistent results were found in clinical studies. This study sought to quantitatively summarize the blood and cerebrospinal fluid (CSF) oxidative stress marker data in PD patients. We performed a systematic search of PubMed and Web of Science, and studies were included if they provided data on peripheral blood and CSF oxidative stress marker concentrations in PD patients and healthy control (HC) subjects. Data were extracted by three independent investigators from 80 included studies encompassing 7,212 PD patients and 6,037 HC subjects. Of the 22 oxidative stress markers analyzed, random effects meta-analysis showed that blood concentrations of 8-OhdG, MDA, nitrite, and ferritin were increased in patients with PD compared with HC subjects. In contrast, we showed that blood levels of catalase, uric acid, glutathione, and total-cholesterol were significantly down-regulated in patients with PD when compared with controls. There were no significant differences between PD patients and HC subjects for blood, Mn, Cu, Zn, Fe, SOD, albumin, glutathione peroxidase, vitamin E, ceruloplasmin, triglycerides, lactoferrin, transferrin, LDL-cholesterol, and HDL-cholesterol. Due to the limited number of CSF studies with small sample size, this meta-analysis only showed non-significant association between CSF 8-OhdG and PD. The findings of our meta-analysis demonstrated higher blood concentrations of 8-OhdG, MDA, nitrite and ferritin, and lower blood concentrations of catalase, uric acid, glutathione and total-cholesterol in PD patients, strengthening the clinical evidence that PD is accompanied by increased oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Parkinson's Disease: A Systematic Review and Meta-Analysis

Wei

et al. 2018

Front. Mol. Neurosci.

227

165

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“…Gruden et al (2012) demonstrated that the plasma activity of SOD in PD patients was diminished. Yuan et al (2016) found that plasma activity of SOD in de novo Chinese PD patients were lower than in HCs. Furthermore, Li et al, 2017 generated MPTP-treated PD monkey model and found that serum SOD showed continuously decrease.…”

Section: Discussionmentioning

confidence: 93%

Contra-Directional Expression of Plasma Superoxide Dismutase with Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson’s Disease Severity

Yang

Chang

Que

et al. 2020

Front. Aging Neurosci.

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Aim: Oxidative stress and inflammation play critical roles in the neuropathogenesis of PD. We aimed to evaluate oxidative stress and inflammation status by measuring serum superoxide dismutase (SOD) with lipoprotein cholesterol and high-sensitivity C-reactive protein (hsCRP) respectively in PD patients, and explore their correlation with the disease severity. Methods: We performed a cross-sectional study that included 204 PD patients and 204 age-matched healthy controls (HCs). Plasma levels of SOD, hsCRP, total cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. A series of neuropsychological assessments were performed to rate the severity of PD. Results: The plasma levels of SOD (135.7 ± 20.14 vs. 147.2 ± 24.34, P < 0.0001), total cholesterol, HDL-C and LDL-C in PD were significantly lower than those in HCs; the hsCRP level was remarkably increased in PD compared to HC (2.766 ± 3.242 vs. 1.637 ± 1.597, P < 0.0001). The plasma SOD was negatively correlated with the hsCRP, while positively correlated with total cholesterol, HDL-C, and LDL-C in PD patients. The plasma SOD were negatively correlated with H&Y, total UPDRS, UPDRS (I), UPDRS (II), and UPDRS (III) scores, but positively correlated with MoCA and MMSE scores. Besides,

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“…51 Different studies have also reported significant decrease of iron level in the blood serum of MCI and AD patients. 52−,,56 In PD, plasma GSH is depleted 71 and serum iron level is increased significantly compared to control participants 72 or increased (non-significantly). 73 A meta-analysis, taking into consideration ethnicity, showed that the serum iron levels in PD patients were significantly higher than controls both in Asian populations and European populations.…”

Section: ■ Discussionmentioning

confidence: 99%

Quantitation of Brain and Blood Glutathione and Iron in Healthy Age Groups Using Biophysical and In Vivo MR Spectroscopy: Potential Clinical Application

Mandal,

Dwivedi,

Joon

et al. 2023

ACS Chem. Neurosci.

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The antioxidant glutathione (GSH) and pro-oxidant iron levels play a balancing role in the modulation of oxidative stress (OS). There is a significant depletion of GSH in the left hippocampus (LH) in patients with Alzheimer’s disease (AD) with concomitant elevation of iron level. However, the correlation of GSH and iron distribution patterns between the brain and the peripheral system (blood) is not yet known. We measured GSH and magnetic susceptibility (e.g., iron) in the LH region along with GSH in plasma and iron in serum across four age groups consisting of healthy volunteers (age range 18–72 y, n = 70). We report non-variability of the mean GSH in the plasma and LH region across mentioned age groups. The mean iron level in the LH region does not change, but the iron level in the serum in the 51–72 y age group increases non-significantly. Regression analysis of our data indicated that GSH and iron levels (both in blood and in brain) are not related to age. This research pave the way for the identification of a risk/susceptibility biomarker for AD and Parkinson’s disease from the evaluation of GSH (in plasma) and iron (in serum) levels concomitantly.

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Plasma antioxidant status and motor features inde novoChinese Parkinson's disease patients

Abstract: Our study demonstrates that the plasma antioxidant status is impaired in de novo Chinese PD patients. The complex relationship between the plasma antioxidant status and different motor features indicates that the antioxidant mechanisms underlying tremor and PIGD of PD may be different.

Cited by 11 publications

References 36 publications

Oxidative Stress in Parkinson's Disease: A Systematic Review and Meta-Analysis

Oxidative Stress in Parkinson's Disease: A Systematic Review and Meta-Analysis

Contra-Directional Expression of Plasma Superoxide Dismutase with Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson’s Disease Severity

Quantitation of Brain and Blood Glutathione and Iron in Healthy Age Groups Using Biophysical and In Vivo MR Spectroscopy: Potential Clinical Application

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