Plasma antioxidant and hepatic enzymes activity, thyroid hormones alterations and health status of liver tissue in common carp (Cyprinus carpio) exposed to lufenuron

Ghelichpour, Melika; Mirghaed, Ali Taheri; Hoseini, Seyyed Morteza; Pérez‐Jiménez, Amalia

doi:10.1016/j.aquaculture.2019.734634

Cited by 53 publications

(23 citation statements)

References 56 publications

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“…Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copy • Author Copy pesticides, different histopathological variations shown in liver[40]. In our study, various histopathological changes observed in liver of grass carp when exposed to three chemicals (emamectin, acetochlor and topsin-M) such as necrosis, pyknosis, lymphocytes infilteration, dissolution of plasma membrane, blood congestion and vacuolation which is in agreement with[41] who reported similar histopathological alterations in the liver of Common carp on exposure to lufenuron. As reported by[15] endosulfan toxic effects on liver cells of C. idella showed hepatocytes swelling, pyknotic nucle i, vacuolations in hepatocytes, necrosis, blood vessels congestion [42].…”

supporting

confidence: 87%

Comparative Effects of Selected Agrochemicals on Biochemical Profile and Histopathology of Grass-Carp (<i>Ctenopharyngodon idella</i>)

Khan¹,

Ahmad²,

Ghayyur³

et al. 2022

Pol. J. Environ. Stud.

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The current study was designed to evaluate the comparative effects of three selected chemicals such as emamectin (insecticide), acetochlor (herbicide) and topsin-M (fungicide) on haematology, biochemical profile and histopathology of grass carp (Ctenopharyngdon idella). A total of forty C. Idella was collected from fish farm Hattian Kamra and transported to the Chemistry lab of Government Post Graduate College Haripur in plastic bags containing dissolve oxygen. After acclimatization for a week they were randomly segregated in four groups (E0, E1, E2 and E3) and treated with 5ppb emamectin, acetochlor and topsin-M respectively. After 96hrs of chemical treatment, blood and tissue samples were collected from both control and treated groups for investigation of biochemical and histopathological alterations. Obtained results exhibited significant alteration in haematological parameters i.e. total white blood cells count, MCV, MCH and number of platelets significantly (p<0.05) increased while Red blood cells count, hemoglobin, PCV and MCHC significantly (p<0.05) decreased in the experimental groups E1, E2 and E3 as compared to control group. Significant (p<0.05) changes were observed in biochemical parameters i.e. increase in serum glucose, bilirubin, albumins, blood urea, uric acid, cholesterol, serum calcium, phosphorous, sodium, potassium, serum lipase, CKP, LDH and CK MB, while significant decrease in creatinine, triglycerides, HDL-cholesterol, serum iron, serum amylase, SGPT, alkalinity and Phosphate was observed. The observed Histopathological changes in gills include epithelial

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supporting

confidence: 87%

Comparative Effects of Selected Agrochemicals on Biochemical Profile and Histopathology of Grass-Carp (<i>Ctenopharyngodon idella</i>)

Khan¹,

Ahmad²,

Ghayyur³

et al. 2022

Pol. J. Environ. Stud.

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“…MPO and GSH-Px are markers that reflect antioxidant activity (Holanda et al, 2021). TBARS, as a main secondary product of oxidative stress, is convenient for monitoring of the oxidative pressure (Ghelichpour et al, 2020). Among of TBARS, MDA is the main composition, and toxic to proteins and DNA (El-Houseiny & Khalil, 2020;Souza & Ferreira, 1985).…”

Section: Discussionmentioning

confidence: 99%

Dietary grape seed proanthocyanidins improved growth, immunity, antioxidant, digestive enzymes activities, and intestinal microbiota of juvenile hybrid sturgeon ( Acipenser baeri Brandt ♀ × A. schrenckii Brandt ♂)

Wang

et al. 2021

Aquacult Nutr

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An 8-week growth trial was performed to evaluate the effects of grape seed proanthocyanidins (GSPs) on growth, digestive enzymes, body composition, intestinal microbiota, serum immunological, anti-oxidative and biochemical parameters of juvenile hybrid sturgeon (Acipenser baeri Brandt ♀ × A. schrenckii Brandt ♂). Fish were randomly divided to control, GSPs-50 and GSPs-100 groups, which were fed with a basal diet and basal diet supplemented with 50 and 100 mg/kg GSPs, respectively. Growth performance and digestive enzymes were improved by GSPs in sturgeon (p < .05).Lysozyme was clearly increased in serum when sturgeon fed with GSPs diets, while the thiobarbituric acid reactive substances (TBARS) displayed opposite trend (p < .05).Myeloperoxidase and glutathione peroxidase in serum of GSPs-50 were higher than control and GSPs-100 (p < .05). Serum parameters showed alanine aminotransferase, alkaline phosphatase and γ-glutamyl transpeptidase of GSPs-50 were lower than control (p < .05). Compared with the control treatment, GSPs-100 reduced alanine aminotransferase and γ-glutamyl transpeptidase and increased aspartate aminotransferase and lactate dehydrogenase (p < .05). High-throughput sequencing revealed that adding 50 mg/kg GSPs not only modified the microbiota diversity, but also reduced the relative abundance of Aeromonas in sturgeon intestine. In conclusion, GSPs are a promising feed additive to promote growth, immunity, antioxidant and digestive enzyme activities and improve serum biochemical parameters and intestinal microbiota of hybrid sturgeon.

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“…Oxidant-mediated responses, such as apoptotic or necrotic cell death, membrane lipid peroxidation, metabolic perturbation, and deregulation of several signaling pathways) are several well-known toxicological effects of insecticides 93,94 . Hence, the study of antioxidant enzymes has been used as a popular method to evaluate the response of multiple animal models, including rats, mice, fish, and green snake head, under pesticide-induced stress conditions 78,[95][96][97][98][99][100] . In the present study, lufenuron was found to increase the level of MDA and decrease the level of GPx and SOD enzymes in liver cells in mothers and their fetuses in a dose-dependent manner, which refers to the oxidative stress posed by the insecticide on the liver cells of the treated animals.…”

Section: Discussionmentioning

confidence: 99%

Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses

Basal

Ahmed

Mahmoud

et al. 2020

Sci Rep

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Insecticides and other agrochemicals have become indispensable components of the agricultural system to ensure a notable increase in crop yield and food production. As a natural consequence, chemical residues result in significantly increased contamination of both terrestrial and aquatic ecosystems. The present study evaluated the teratogenic, genotoxic, and oxidative stress effects of residual-level lufenuron exposure on pregnant rats during the organogenesis gestational period of both mother and fetus. The tested dams were divided into three groups; control (untreated), low-dose group (orally administered with 0.4 mg/kg lufenuron) and high-dose group (orally administered with 0.8 mg/kg lufenuron). The dams of the two treatment groups showed teratogenic abnormalities represented by the asymmetrical distribution of fetuses in both uterine horns, accompanied by observed resorption sites and intensive bleeding in the uterine horns, whereas their fetuses suffered from growth retardation, morphologic malformations, and skeletal deformations. Histologic examination of the liver and kidney tissues obtained from mothers and fetuses after lufenuron exposure revealed multiple histopathologic changes. DNA fragmentation and cell cycle perturbation were also detected in the liver cells of lufenuron-treated pregnant dams and their fetuses through comet assay and flow cytometry, respectively. Moreover, lufenuron-induced oxidative stress in the liver of mothers and fetuses was confirmed by the increased malondialdehyde levels and decreased levels of enzymatic antioxidants (glutathione peroxidase and superoxide dismutase). Taken together, it can be concluded that lufenuron has a great potential in exerting teratogenic, genotoxic, and oxidative stresses on pregnant rats and their fetuses upon chronic exposure to residual levels during the organogenesis gestational period. The obtained results in the present study imply that women and their fetuses may have the same risk.

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Plasma antioxidant and hepatic enzymes activity, thyroid hormones alterations and health status of liver tissue in common carp (Cyprinus carpio) exposed to lufenuron

Cited by 53 publications

References 56 publications

Comparative Effects of Selected Agrochemicals on Biochemical Profile and Histopathology of Grass-Carp (<i>Ctenopharyngodon idella</i>)

Comparative Effects of Selected Agrochemicals on Biochemical Profile and Histopathology of Grass-Carp (<i>Ctenopharyngodon idella</i>)

Dietary grape seed proanthocyanidins improved growth, immunity, antioxidant, digestive enzymes activities, and intestinal microbiota of juvenile hybrid sturgeon ( Acipenser baeri Brandt ♀ × A. schrenckii Brandt ♂)

Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses

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