Plasma Antihaemophilic Factor (AHF) Concentrations in Families of Patients with Haemorrhagic States

Pitney, W. R.; Arnold, Brent L.

doi:10.1111/j.1365-2141.1959.tb04024.x

Cited by 42 publications

(22 citation statements)

References 22 publications

(19 reference statements)

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“…Our findings suggest that such changes continue into old age. There has also been controversy as to the effects of sex and advancing years on factor VIII concentrations (Pitney and Arnold, 1959;Cooperberg and Teitelbaum, 1960;Pitney, Kirk, Arnold, and Stenhouse, 1962;Preston and Barr, 1964;Korsan-Bengtsen et al, 1973). In the small numbers studied here no significant differences in factor VIII levels were found amongst the different groups examined.…”

Section: Obesity and Coagulation Factorscontrasting

confidence: 56%

The effect of age upon the coagulation system

Hamilton¹,

Allardyce²,

Ogston³

et al. 1974

J Clin Pathol

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SYNOPSIS Factors V, VII, VIII, X, XI, and XII of the coagulation system, platelet count, and antithrombin III levels were assayed in 20 healthy volunteers aged 20-40 years and 61 elderly subjects aged 66-96 years whose skinfold thickness was also measured. Factors XI, XII, and antithrombin III levels tended to increase in women and decrease in men while factors X, VII, and V tended to increase in both males and females with advancing years. No age or sex differences were found in platelet counts or factor VIII levels. Factor VIII levels were inversely correlated with obesity in elderly males (r = -0-56, P < 0-005).

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Section: Obesity and Coagulation Factorscontrasting

confidence: 56%

The effect of age upon the coagulation system

Hamilton¹,

Allardyce²,

Ogston³

et al. 1974

J Clin Pathol

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“…Many investigators have attempted to identify hemophilic carriers on the basis of their functional AHF titers (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). In all sufficiently large modern series, some carriers had abnormally low titers of AHF, but in most the majority fell within the normal range.…”

Section: Discussionmentioning

confidence: 99%

“…Previous attempts to define the carrier state in this disease have depended upon measurement of AHF procoagulant activity (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). As a group, carriers of hemophilia have a lower mean AHF activity than normal women, while nearly half of individual carriers have titers of AHF that are distinctly low.…”

Section: Introductionmentioning

confidence: 99%

Detection of carriers of classic hemophilia using an immunologic assay for antihemophilic factor (factor VIII)

Zimmerman¹,

Ratnoff²,

Littell³

1971

J. Clin. Invest.

179

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“…In apparent confirmation, Gardikas, Katsiroumbas and Kottas (3) reported normal AHG levels in ten obligatory carriers of severe hemophilia. However, several subsequent groups of workers (4)(5)(6) demonstrated diminished levels of AHG in some carriers of both mild and severe hemophilia; and, recently, Nilsson and co-workers (1) reported that the vast majority of carriers have low levels of AHG.…”

mentioning

confidence: 99%