Plasma angiotensin-converting enzyme activity and carotid wall thickening.

Associations between circulating components of the renin-angiotensin-aldosterone system and left ventricular mass.

“…In addition to the present finding, myocardial infarction, diabetic nephropathy, and carotid artery thickening have been associated with raised serum ACE concentrations. '8 [29][30][31] Furthermore, in children, serum ACE activity was found to be related to the level of arterial blood pressure. 16 Serum and tissue ACE activities are largely determined by genetic disposition and vary little in a given individual.…”

“…(Heart 1997;77: [24][25][26][27][28][29][30][31] Keywords: angiotensin converting enzyme; aldosterone; angiotensinogen; left ventricular hypertrophy Left ventricular hypertrophy is associated with a markedly increased incidence of myocardial infarction,l heart failure, or premature death.2 4Traditionally, chronic pressure overload of the heart, imposed by arterial hypertension or valvar heart disease, is considered to be the aetiological factor responsible for this major risk factor.5 In recent years, however, experimental investigations directed interest to the question whether neurohormonal stimulation may contribute to the development of left ventricular hypertrophy. 6 In particular, numerous studies on isolated myocytes or isolated experimental hearts provided convincing evidence that angiotensin II or adrenergic agonists may accelerate myocardial growth even when haemodynamic load is low.…”

Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease

“…The ACE genotype also affects the pathologies of the vascular endothelial tissue (Johnston, 1994;Morishita et al, 1994). Serum ACE activity, MI, and CAD are related (Marian et al, 1993;Cambien et al, 1994;Payne et al, 1994). The D allele and serum ACE activity are considered to be risk factors for the development of CAD (Turgut, 2005).…”