Plasma and urinary excretion kinetics of oral baclofen in healthy subjects

Wuis, E.W.; Dirks, M. J. M.; Termond, E. F. S.; Vree, T. B.; Kleijn, Eppo van der

doi:10.1007/bf00558228

Cited by 91 publications

(77 citation statements)

References 12 publications

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“…Chodorowski et. al detected 12/18 patients (66%) admitted to the clinic in deep coma, 10/18 patients (55.5%) with acute respiratory failure and cardiac abnormalities including bradycardia (44.4%), hypertension (33.0%) and hypotension (5.5%) in toxication [1]. Baclofen is rapidly and extensively absorbed and eliminated.…”

Section: Discussionmentioning

confidence: 99%

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Baclofen Intoxication in a Patient with Chronic Renal Failure

2016

J Ann Eu Med

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ÖzetBaklofen γ-aminobütirik asit (GABA) türevi olup, spastisite tedavisinde kullanıl-maktadır. Baklofen toksititesi kas gevşemesi, ciddi solunum depresyonu, nöbet, koma, bradikardi/taşikardi ya da hipotansiyon/hipertansiyona neden olabilir. Kronik böbrek yetmezliği olan 60 yaşındaki hastanın düşük doza rağmen baklofen intoksikasyonuna bağlı stupor ile başvurusunu sunduk. Anahtar KelimelerBaklofen İntoksikasyonu, Kronik Böbrek Yetmezliği, Bilinç Bulanıklığı AbstractBaclofen is a derivative of γ-aminobutyric acid (GABA), is used in the treatment of spasticity. Baclofen toxicity can cause muscle flaccidity, severe respiratory depression, seizure, coma, bradycardia/tachcardia, or hypotension/hypertension. We report on a 60-year-old female patient with chronic renal failure who presented with stupor due to baclofen intoxication in spite of low dosage.

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Section: Discussionmentioning

confidence: 99%

“…Baclofen is eliminated predominantly by the kidneys and patients with impaired renal function have particular risk for baclofen accumulation [1]. Some authors have suggested that haemodialysis is effective in the removal of baclofen, however the pharmakokinetics of baclofen elimination during haemodialysis remains unclear [2].…”

Section: Introductionmentioning

confidence: 99%

Baclofen Intoxication in a Patient with Chronic Renal Failure

2016

J Ann Eu Med

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“…Baklofenin büyük bir kısmı böbreklerden elimine olmaktadır (4). Son dönem böbrek yetersizliği olan hastalarda baklofen birikimi olduğu ve yarılanma ömrünün uzadığı belirtilmektedir (19). Yapılan birçok çalışmada renal yetersizliği olan ciddi baklofen toksisite olgularında hemodiyaliz uygulamaları ile serum baklofen kosantrasyonun hızla düştüğü, baklofen yarılanma ömrünün kısaldığı ve klinik semptomların hızla iyileştiği gösterilmiştir (20)(21)(22)(23)(24).…”

Section: Discussionunclassified

Baclofen Intoxication

Bor¹,

Karaca²,

Karakoç³

et al. 2015

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“…The slow speed of injection reduced the initial distribution of baclofen along the spinal canal [12]. Biotransformation of baclofen is low and the drug is predominantly excreted unchanged by the kidneys [13].…”

Section: Discussionmentioning

confidence: 99%

The effect of intrathecal baclofen single injection on neuropathic pain

Lee

Kim

et al. 2016

Anesth Pain Med

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Background:Baclofen is a gamma-aminobutyric acid B-receptor agonist, which is usually used for patients with spasticity or patients with nerve injury inducing both spasticity and neuropathic pain. Both oral administration and intrathecal injection via a continuous infusion pump are common treatment methods. The aim of this study was to evaluate the effectiveness of a series of three individual injections of intrathecal baclofen for neuropathic pain without spasticity. Methods: Thirty-one patients with neuropathic pain were treated with a series of three monthly individual injections of intrathecal baclofen without pump implantation A dose of 50 g of baclofen was used. 10-cm visual analog scale (VAS) scores of spontaneous pain, allodynia, and hyperalgesia were recorded a week after each injection. Vital signs were monitored to detect any hemodynamic changes, and a myelogram was performed to detect any undesirable cerebrospinal fluid leakage. All patients were hospitalized for at least one day following each injection for close observation and to control any adverse effects. Results: VAS scores of spontaneous pain, allodynia, and hyperalgesia decreased significantly (P ＜ 0.001). The major complications were general weakness, sleepiness, and urinary retention; most of these resolved within one day without any further serious symptoms. Conclusions: A series of three individual intrathecal baclofen injections was effective for those patients who suffered from neuropathic pain without spasticity or dystonia; no serious complications were observed. However, the average satisfaction score recorded for spontaneous pain was lower than those for allodynia and hyperalgesia. (Anesth Pain Med 2016; 11: 399-403)

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Plasma and urinary excretion kinetics of oral baclofen in healthy subjects

Cited by 91 publications

References 12 publications

Baclofen Intoxication in a Patient with Chronic Renal Failure

Baclofen Intoxication in a Patient with Chronic Renal Failure

Baclofen Intoxication

The effect of intrathecal baclofen single injection on neuropathic pain

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