Plasma and urinary amino acids and selected sulfur metabolites in young men fed a diet devoid of methionine and cystine

Lakshmanan, Florence Lazicki; Perera, W D A; Scrimshaw, Nevin S.; Young, Vernon R.

doi:10.1093/ajcn/29.12.1367

Cited by 25 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 h after beginning the diet, and by 43% on D3 of the diet in metastatic colorectal cancer patients. This reduction threshold for plasma MET was consistent with previous reports in healthy men [22] on an oral MET-free diet (49% at 3 h, 60% at 2 days) and in patients with metastatic solid cancer [23]with enteral MET restriction (42% at 4 days). In our previous phase I clinical trial testing the association of a MET-free diet with nitrosourea chemotherapy in metastatic melanoma and recurrent gliomas, the MET-free diet induced a maximal decrease of 55% in the plasma MET concentration 4 h after beginning diet administration without an effect on the extent of the MET-free diet period [24].…”

Section: Discussionsupporting

confidence: 92%

Dietary Methionine Restriction with FOLFOX Regimen as First Line Therapy of Metastatic Colorectal Cancer: A Feasibility Study

Durando¹,

Farges²,

Buc³

et al. 2010

Oncology

View full text Add to dashboard Cite

The methionine (MET) dependency of tumor cells opens interesting perspectives for targeting tumor cells and potentiating chemotherapy treatment, like 5-fluorouracil (5-FU) and platinum compound. Since MET deprivation can individually potentiate the different chemotherapeutic agents used in the 48-hour combined regimen of 5-FU, leucovorin and oxaliplatin (FOLFOX) regimen, we initiated a feasibility study associating dietary MET restriction with the FOLFOX regimen in patients with metastatic colorectal cancer. Objectives: (i) To evaluate the depletion in the plasma MET concentration, and (ii) to assess the feasibility of this combination. Methods: Eleven patients were enrolled in this study. They received a median number of 3 two-week cycles of a MET-free diet (3 consecutive days) and FOLFOX6 regimen. Results: The plasma MET concentration was reduced by dietary MET restriction, with a depletion of 58% on the 1st day of MET-free diet. Indeed, we demonstrated the feasibility and good tolerance (nutritional status and toxicity) of the association of a MET-free diet with the FOLFOX regimen. Despite good compliance to the diet, this study revealed the difficulty of administering this combination during further months. Among the 4 patients evaluable for response, 3 experienced a partial response and 1 patient a disease stabilization.

show abstract

Section: Discussionsupporting

confidence: 92%

Dietary Methionine Restriction with FOLFOX Regimen as First Line Therapy of Metastatic Colorectal Cancer: A Feasibility Study

Durando¹,

Farges²,

Buc³

et al. 2010

Oncology

View full text Add to dashboard Cite

show abstract

“…The observed reduction threshold for plasma MET was consistent with previous reports (18)(19)(20)(21)(22)(23)(24)(25)(26). In a clinical trial performed in healthy men, Lakshmanan et al (18) reported a 49% decrease of plasma MET levels after 3 h of an oral MET-free diet and a 60% decrease after 2 days (fed state). In a Phase I clinical trial in 8 patients with a variety of metastatic solid cancer, Epner et al (26) reported a 42% decline of plasma MET at fed state after 4 days of enteral MET restriction and a reduction threshold of 58% within 2 wk.…”

Section: Discussionsupporting

confidence: 90%

“…Four periods of 1, 2, 3, or 4 days of MET-free diet were randomly tested during the 4 cycles. As shown by Lakshmanan et al (18) on healthy subjects, a significant plasma MET depletion was observed 3 h after the beginning of a similar oral MET-free diet. We chose to administer cystemustine treatment at 12 AM (i.e., 4 h after diet beginning) on the last day of the MET-free diet period.…”

Section: Treatment Schedulementioning

confidence: 55%

Optimal Methionine-Free Diet Duration for Nitrourea Treatment: A Phase I Clinical Trial

Durando

Thivat

Farges

et al. 2007

Nutrition and Cancer

View full text Add to dashboard Cite

In animal models, methionine (MET) restriction in association with chloroethylnitrosoureas led to a substantial improvement. On this basis, we initiated a Phase I clinical trial of dietary MET restriction in association with chloroethylnitrosourea (cystemustine) treatment for patients with recurrent glioma or metastatic melanoma. Our purpose was 1) to determine the optimal MET-free diet duration for a maximum depletion of plasma MET and 2) to evaluate the feasibility of this association. A total of 10 patients received 4 cycles of 2 wk of an association of a MET-free diet of 1, 2, 3, or 4 consecutive days and cystemustine (60 mg/m(2)). For each cycle, plasma MET concentrations, nutritional status (weight, albumin, prealbumin) and toxicity were measured. Conversely, fed-state concentrations of plasma MET (12 AM) were reduced by dietary MET restriction, with an optimal depletion of 41% at the 1st day of MET-free diet without effect of the extending MET-free diet period. Indeed, we demonstrated the feasibility, that is, good diet acceptability and good tolerance (nutritional status and toxicity), of the association of a MET-free diet and cystemustine treatment. Based on these results, a Phase II clinical trial has been initiated to test the activity of the association of a 1-day MET-free diet with cystemustine treatment.

show abstract

“…Adult volunteers given three different levels of protein intake excrete in their urinary output SO 4 ‫מ2‬ values highly correlated (r 0·88) with dietary N intake (Wright et al 1960). Similar high correlations are found in healthy adults submitted, during an 8 d period, to SAA-deprived regimens and displaying significantly depressed sulfaturia (Lakshmanan et al 1976). In contrast, stepwise increases in the supply of dietary SAA ranging from normal (0·8 g/d) to high (4 g/d) levels result in a high correlation (r 0·98) with renal SO 4 ‫מ2‬ output (Sabry et al 1965).…”

Section: ‫מ2‬supporting

confidence: 66%

The essentiality of sulfur is closely related to nitrogen metabolism: a clue to hyperhomocysteinaemia

Ingenbleek¹,

Young

2004

Nutr. Res. Rev.

View full text Add to dashboard Cite

N and S metabolisms are closely interwoven throughout both the plant and animal kingdoms. The essentiality of S relates to its participation in the structure of S-containing amino acids (SAA), to its inclusion in many sulfonated molecules, and to a myriad of metabolic and catalytic reactions of vital importance. Methionine (Met) is the indispensable SAA supplied by food proteins and its plasma homeostasis is achieved via a number of highly efficient regulatory mechanisms. In all conditions characterised by a negative body protein balance such as in dietary restriction or cytokine-induced hypercatabolic losses, N and S endogenous pools manifest parallel tissue depletion rates. Adaptive conservation of N and S body stores is reached by a functional restraint of the trans-sulfuration cascade, through the depression of cystathionine ␤-synthase activity. As a result, upstream accumulation of homocysteine favours its re-methylation conversion to Met which helps maintain metabolic pathways of survival value. In addition to the measurement of vitamin indices, that of plasma transthyretin, a sensitive marker of protein nutritional status, is proposed to identify the fluctuations of the total body N component accountable for the alterations of homocysteine concentrations in body fluids.

show abstract

Plasma and urinary amino acids and selected sulfur metabolites in young men fed a diet devoid of methionine and cystine

Cited by 25 publications

References 14 publications

Dietary Methionine Restriction with FOLFOX Regimen as First Line Therapy of Metastatic Colorectal Cancer: A Feasibility Study

Dietary Methionine Restriction with FOLFOX Regimen as First Line Therapy of Metastatic Colorectal Cancer: A Feasibility Study

Optimal Methionine-Free Diet Duration for Nitrourea Treatment: A Phase I Clinical Trial

The essentiality of sulfur is closely related to nitrogen metabolism: a clue to hyperhomocysteinaemia

Contact Info

Product

Resources

About