Plasma and Tissue Levels of Magnesium in Chronically Hemodialyzed Patients: Effects of Dialysate Magnesium Levels

Changes in Erythrocyte Ca2+, K+, and Mg2+ Content in Uremic Patients on CAPD

“…This could explain the high erythrocyte Mg 2+ levels in some pathological conditions, such as uremia, in which erythrocyte survival is shortened and patients receive EPO for the preservation of a stable near normal Hct. Some older reports (pre-EPO treatment) support the idea that high erythrocyte Mg 2+ content is related to low Hct in uremic patients (6,15). This is not supported by our findings because our patients received EPO and Hcts ranged between 32% and 41%.…”

Dialysate Magnesium

“…Since then, conflicting results have been reported with the use of high DMg. Some studies found decreased PTH release in uremic patients when DMg was increased (53, 67, 68), while others have reported no change or the opposite effect (47,62,69). Overall, the evidence for clinically significant long-term suppression of PTH by increased SMg in uremics is lacking (65).…”

Magnesium and Bone Disease

“…Bone magnesium content in the dialysis patient has recently been reviewed elsewhere [65]; the current hypo thesis is that elevated bone magnesium arises from in creased serum magnesium and that elevated bone mag nesium plays a part in mineralization defects and the pathogenesis of renal osteodystrophy. Decreasing dialysate magnesium leads to a decline in bone magnesium.…”