Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments

Piccinni, Armando; Marazziti, Donatella; Catena, Mario; Domenici, Luciano; Debbio, Alessandro Del; Bianchi, Carolina; Mannari, Claudio; Martini, Claudia; Pozzo, Eleonora Da; Schiavi, Elisa; Mariotti, A; Roncaglia, Isabella; Palla, A.; Consoli, G.; Giovannini, Luca; Massimetti, Gabriele; Dell’Osso, Liliana

doi:10.1016/j.jad.2007.05.005

Cited by 179 publications

(134 citation statements)

References 25 publications

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“…71 However, plasma BDNF has been hypothesized to behave as a state-dependent marker, while serum BDNF might signify illness. 72 Such differences in serum and plasma BDNF expression could explain the findings of similar studies that assessed serum BDNF levels but did not find elevated BDNF expression during the period of early cocaine detoxification in humans.…”

Section: Discussionmentioning

confidence: 94%

Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress

Viola

Tractenberg

Levandowski

et al. 2014

J Psychiatry Neurosci

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Section: Discussionmentioning

confidence: 94%

Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress

Viola

Tractenberg

Levandowski

et al. 2014

J Psychiatry Neurosci

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“…8 studies comparing serum BDNF levels in depressed subjects before and after antidepressant treatment were identified and included for our second analysis. Although there are now a few recent studies suggesting plasma BDNF content is also decreased in depressed subjects (19,(21)(22)(23), this data was not included in this analysis in order to minimize potential confounds.…”

Section: Studiesmentioning

confidence: 99%

“…Sensitivity Analysis -Serum BDNF and Depression Status Study Recalculated P value Table 4 Sensitivity Analysis -Serum BDNF and Antidepressant Treatment Study Recalculated P value Huang (47) 0.002 Piccinni (19) 0.013 Yoshimura (18) 0.019 Aydemir -A (45) 0.016 Gervasoni (44) 0.013 Gonul (48) 0.029 Aydemir -B (46) 0.002 Hellweg (50) 0.004…”

mentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen

Duman

Sanacora

2008

Biological Psychiatry

1,072

706

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“…A clinical study in 2004 has shown that serum BDNF levels negatively correlated with the depression-related personality traits (Lang et al, 2004). Afterwards, serum and plasma BDNF levels have been found decreased in patients with major depressive disorder (MDD) (Lee et al, 2007;Piccinni et al, 2008). These clinical studies have suggested that peripheral BDNF levels can serve as a biomarker for depression.…”

Section: Introductionmentioning

confidence: 99%

ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress

Bai

Ruan

Yang

et al. 2016

Neuropsychopharmacol

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Chronic exposure to stressful environment is a key risk factor contributing to the development of depression. However, the mechanisms involved in this process are still unclear. Brain-derived neurotropic factor (BDNF) has long been investigated for its positive role in regulation of mood, although the role of its precursor, proBDNF, in regulation of mood is not known. In this study, using an unpredictable chronic mild stress (UCMS) paradigm we found that the protein levels of proBDNF were increased in the neocortex and hippocampus of stressed mice and this UCMS-induced upregulation of proBDNF was abolished by chronic administration of fluoxetine. We then established a rat model of UCMS and found that the expression of proBDNF/p75 NTR /sortilin was upregulated, whereas the expression of mature BDNF and TrkB was downregulated in both neocortex and hippocampus of chronically stressed rats. Finally, we found that the injection of anti-proBDNF antibody via intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) approaches into the UCMS rats significantly reversed the stress-induced depression-like behavior and restored the exploratory activity and spine growth. Although intramuscular injection of AAV-proBDNF did not exacerbate the UCMS-elicited rat mood-related behavioral or pathological abnormalities, i.c.v. injection of AAV-proBDNF increased the depression-like behavior in naive rats. Our findings suggest that proBDNF plays a role in the development of chronic stress-induced mood disturbances in rodents. Central (i.c.v.) or peripheral (i.p.) inhibition of proBDNF by injecting specific antiproBDNF antibodies may provide a novel therapeutic approach for the treatment of stress-related mood disorders.

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Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments

Cited by 179 publications

References 25 publications

Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress

Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress

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