Plasma and Platelet Beta-Thromboglobulin Levels in Patients with May-Hegglin Anomaly

Fabris, Fabrizio; Casonato, Alessandra; Randi, M. L.; Girolami, Antonio

doi:10.1159/000214348

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…The variable degree of macrothrombocytopenia that is usually present has been associated with a mild bleeding tendency in some patients. No abnormality could be detected in either the membranes [ 3 ] or the B-globulin content [4] of these platelets. Although severe bleeding diathesis due to thrombocytopenia or increased bleeding time happens rarely, it appears that, in the event of this occurring with threat to life or organs (e.g., intraocular hemorrhage), splenectomy may be considered, especially if splenic sequestration can be demonstrated [ 5 ] .…”

Section: Introductionmentioning

confidence: 74%

Coincidental finding of May‐Hegglin anomaly in a patient with end‐stage renal failure

et al. 1992

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We present two cases of May-Hegglin anomaly incidentally discovered in a patient and his brother during investigation of the patient for end-stage renal failure and workup for renal transplantation. Routine laboratory tests were performed and included a basically normal clotting profile. Ultrastructural studies of the May-Hegglin inclusions proved diagnostic, findings were compared with those of two similar granulocyte inclusion bodies, and nomenclature discrepancies that still exist in most references are again emphasized. The finding of the May-Hegglin anomaly in our patient appears to be incidental to the underlying renal disease. A successful renal transplant has been carried out in this patient. We now report on a patient and his brother in which the MHA was discovered during workup of the patient for end-stage renal failure and renal transplantation. No association between the underlying renal disease and the MHA could be demonstrated.

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Section: Introductionmentioning

confidence: 74%

Coincidental finding of May‐Hegglin anomaly in a patient with end‐stage renal failure

et al. 1992

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“…This is consistent with previous reports of normal platelet function [10] and morphology [16], as corroborated in our patients. The only known abnormality of the platelets in these patients is their increased size and consequently elevated levels of granule contents [6,7].…”

Section: Discussionmentioning

confidence: 99%

May-Hegglin anomaly: A rare cause of thrombocytopenia

et al. 1992

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A family with four and an unrelated family with three individuals affected by the May-Hegglin anomaly are described. Platelet counts were markedly reduced and were correctly determined only in the counting chamber. Bleeding time and platelet aggregation were always normal, but platelet nucleotide concentrations (ATP and ADP) were elevated. The platelet glycoprotein complexes Ib/IX, IIb/IIIa and Ia/IIa were quantitatively normal. Platelet-associated IgG was slightly elevated, although thrombocytopenia was presumably not caused by an immunological mechanism. Morphological investigations showed giant platelets and spindle-shaped inclusion bodies in the granulocytes, while their function (phagocytic capacity, radical production) was normal. To exclude hereditary types of thrombocytopenia, morphological and family investigations are required to avoid misdiagnosis with far-reaching diagnostic and therapeutic consequences.

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“…Material and methods have been reported in detail elsewhere [4,6,7]. Only pertinent data will be supplied here.…”

Section: Methodsmentioning

confidence: 99%

Increased Number of Pseudodrumsticks in Neutrophils and Large Platelets. A ‘New’ Congenital Leukocyte and Platelet Morphological Abnormality

Girolami¹,

Fabris²,

Casonato³

et al. 1980

Acta Haematol

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2 members of a family, a child and his father, showed a combined morphological abnormality of leukocytes and platelets. The abnormality consisted of the presence of pseudodrumsticks in the neutrophils and of large platelets. One or more than one pseudodrumstick was present in about 40% of neutrophils. Leukocyte count, differential count and enzymatic stains were normal. Large platelets constituted about 25% of the platelet population. 1 patient also had mild thrombocytopenia which appeared to be unrelated to the basic defect since it appeared after a parotitis infection. Platelet function was normal but for a moderate prolongation of the bleeding time in the patient who had mild thrombocytopenia. No chromosomal abnormality was present in the propositi. The condition seems different from other leukocyte and platelet abnormalities so far described.

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Plasma and Platelet Beta-Thromboglobulin Levels in Patients with May-Hegglin Anomaly

Cited by 4 publications

References 3 publications

Coincidental finding of May‐Hegglin anomaly in a patient with end‐stage renal failure

Coincidental finding of May‐Hegglin anomaly in a patient with end‐stage renal failure

May-Hegglin anomaly: A rare cause of thrombocytopenia

Increased Number of Pseudodrumsticks in Neutrophils and Large Platelets. A ‘New’ Congenital Leukocyte and Platelet Morphological Abnormality

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