Plasma and Peritoneal Poly (ADP-Ribose) Polymerase Levels in Patients with Endometriosis

Kacperczyk‐Bartnik, Joanna; Bartnik, Paweł; Goławski, Ksawery; Sierdziński, Janusz; Mańka, Grzegorz; Kiecka, Mariusz; Lipa, Michał; Warzecha, Damian; Spaczyński, Robert; Piekarski, Piotr; Banaszewska, Beata; Jakimiuk, Artur; Issat, Tadeusz; Rokitaⴕ, Wojciech; Młodawski, Jakub; Szubert, Maria; Sieroszewski, Piotr; Raba, Grzegorz; Szczupak, Kamil; Kluz, Tomasz; Kluza, Marek; Czajkowski, Krzysztof; Wielgoś, Mirosław; Koc-Żórawska, Ewa; Żórawski, Marcin; Laudański, Piotr

doi:10.3390/biomedicines10102451

Cited by 4 publications

(2 citation statements)

References 47 publications

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“…Endometriosis is a chronic inflammatory disease associated with disturbances in the levels of many different active molecules in the eutopic endometrium, peritoneal fluid and plasma, such as those of matrix metalloproteinases, adhesive molecules, cathepsins, chemokines, autoantibodies and other immunologically related substances [7][8][9][10][11][12][13][14]. It is also linked with an increased release of biologically active compounds from erythrocytes into the peritoneal cavity [5,[15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis

Lisowska-Myjak

Skarżyńska

Wróbel

et al. 2023

IJMS

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An evaluation of the association between the concentrations of vitamin D-binding protein and lactoferrin in the plasma and peritoneal fluid may facilitate the elucidation of molecular mechanisms in endometriosis. Vitamin D-binding protein and lactoferrin concentrations were measured by ELISA in plasma and peritoneal fluid samples from 95 women with suspected endometriosis as classified by laparoscopy into groups with (n = 59) and without endometriosis (n = 36). There were no differences (p > 0.05) in the plasma and peritoneal fluid concentrations of vitamin D-binding protein and lactoferrin between women with and without endometriosis. In women with endometriosis, there was a significant correlation between plasma and peritoneal fluid vitamin D-binding protein concentrations (r = 0.821; p = 0.000), but there was no correlation between lactoferrin concentrations in those compartments (r = 0.049; p > 0.05). Furthermore, in endometriosis, lactoferrin was found to correlate poorly with vitamin D-binding protein (r= −0.236; p > 0.05) in plasma, while in the peritoneal fluid, the correlation between those proteins was significant (r = 0.399; p = 0.002). The characteristic properties of vitamin D-binding protein and lactoferrin and the associations between their plasma and peritoneal fluid concentrations found in women with endometriosis may provide a novel panel of markers to identify high-risk patients in need of further diagnostic measures.

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Section: Introductionmentioning

confidence: 99%

Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis

Lisowska-Myjak

Skarżyńska

Wróbel

et al. 2023

IJMS

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“…Non-specific symptoms of endometriosis often result in a disregard of the problem by patients and clinicians, which in turn is associated with a diagnostic delay of 7–9 years [ 7 , 8 ]. Therefore, many researchers are looking for reliable and non-invasive biomarkers for the disease [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis

Warzecha

Załęcka

Mańka³

et al. 2022

IJMS

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Laparoscopy as a diagnostic tool for patients with suspected endometriosis is associated with several potentially life-threatening complications. Therefore, it is imperative to identify reliable, non-invasive biomarkers of the disease. The aim of this study was to analyse the concentrations of fibronectin and type IV collagen in peritoneal fluid and plasma to assess their role as potential biomarkers in the diagnosis of endometriosis. Fibronectin and collagen IV protein levels were assessed by surface plasmon resonance imaging (SPRi) biosensors with the usage of monoclonal antibodies. All patients enrolled in the study were referred for laparoscopy for the diagnosis of infertility or chronic pelvic pain (n = 84). The study group included patients with endometriosis confirmed during surgery (n = 49). The concentration of fibronectin in the plasma (329.3 ± 98.5 mg/L) and peritoneal fluid (26.8 ± 11.1 μg/L) in women with endometriosis was significantly higher than in the control group (251.2 ± 84.0 mg/L, 7.0 ± 5.9 μg/L). Fibronectin levels were independent of endometriosis stage (p = 0.874, p = 0.469). No significant differences were observed in collagen IV levels (p = 0.385, p = 0.465). The presence of elevated levels of fibronectin may indicate abnormalities in cell–ECM signalling during the course of endometriosis, and may be a potential biomarker for early detection.

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Is the leptin/BMI ratio a reliable biomarker for endometriosis?

Zyguła,

Sankiewicz,

Sakowicz

et al. 2024

Front. Endocrinol.

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BackgroundThe aim of this study was to analyze the concentration of leptin in peritoneal fluid and plasma and to assess their role as potential biomarkers in the diagnosis of endometriosis.Materials & methodsLeptin adjusted for BMI (leptin/BMI ratio) was measured using surface plasmon resonance imaging (SPRI) biosensors. Patients with suspected endometriosis were included in the study. Plasma was collected from 70 cases, and peritoneal fluid from 67 cases. Based on the presence of endometriosis lesions detected during laparoscopy, patients were divided into a study group and a control group (patients without endometriosis).ResultsLeptin/BMI ratio in plasma did not differ between women with endometriosis and the control group (0.7159 ± 0.259 vs 0.6992 ± 0.273, p= 0,7988). No significant differences were observed in peritoneal leptin/BMI ratio levels in patients with and without endometriosis (0.6206 ± 0.258 vs 0.6215 ± 0.264, p= 0,9896). Plasma and peritoneal leptin/BMI ratios were significantly lower in women with endometriosis - related primary infertility compared to women with endometriosis without primary infertility (0.640 ± 0.502 vs 0.878 ± 0.623, p < 0.05). The difference was observed in case of primary infertility, but not in terms of the secondary one. No significant differences were noted between leptin/BMI ratio in the proliferative phase and the secretory phase (0.716 ± 0.252 vs 0.697 ± 0.288, p= 0,7785).ConclusionThe results of present study do not support the relevance of leptin concentration determination as a biomarker of the endometriosis. Due to the limited number of samples in the tested group, further studies are needed to confirm its role.

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Plasma and Peritoneal Poly (ADP-Ribose) Polymerase Levels in Patients with Endometriosis

Cited by 4 publications

References 47 publications

Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis

Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis

Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis

Is the leptin/BMI ratio a reliable biomarker for endometriosis?

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