Plasma and human milk concentrations of moclobemide in nursing mothers

Antidepressants and Breast-Feeding

“…Milk to plasma ratios of 0.72 [47] and 0.68, with a range of 0.39 to 1.21 [48] have been reported. A major metabolite, RO 12-8095, was also measured in milk.…”

QSAR analysis of the partitioning of terpenes and terpenoids into human milk

“…Antimalarials, chloroquine, hydroxychloroquine and quinine are found in variable quantities in breast milk 33 . The model predicted an M / P ratio of 2.79 for moclobemide in contrast to the experimentally determined M / P ratio of 0.68, with a range of 0.39‐1.21 22 and M / P of 0.72 34 . These M / P ratios were based on a single dose of moclobemide.…”

“…The human breast milk‐to‐plasma ratio ( M / P ) values of 133 diverse compounds, including drugs and their active metabolites, were taken from the literature 14–23 . In the case of different M/P values for a compound from multiple studies, the average M / P value was calculated, while compounds with highly differing M / P values were excluded from the study.…”

“…The human breast milk-to-plasma ratio (M/P) values of 133 diverse compounds, including drugs and their active metabolites, were taken from the literature. [14][15][16][17][18][19][20][21][22][23] In the case of different M/P values for a compound from multiple studies, the average M/P value was calculated, while compounds with highly differing M/P values were excluded from the study. The 3D molecular structures of the compounds were optimized to minimum energy, and 84 theoretical molecular descriptors were calculated with Molecular Modelling Pro® 5.1 (Chem SW.…”

The impact of childbirth on women's sexuality and methods of treating its disorders

“…Wpływ leku na karmione przez matki zażywające lek noworodki nie jest dobrze zbadany 46 . Istnieją jedyne badania przeprowadzone na małej liczbie noworodków, przez krótki czas, które nie wykazały negatywnego wpływu na ich rozwój i zdrowie 47,48 .…”