Plasma and Erythrocyte Concentrations of Lithium

Zerbi, F; Fenoglio, L.; Tosca, P.

doi:10.1159/000283638

Cited by 5 publications

(2 citation statements)

References 8 publications

(10 reference statements)

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“…In previous experiments carried out in depressed patients treated with lithium, a slowing down of max MeV concurrent with a longer-Iasting evoked muscular response had been reported (Pinelli et al, 1972;Zerbi et al, 1975;Girke et al, 1975). These findings had been correlated with possible functional changes of neuromuscular transmission, due to lithiuminduced electrolytic variations, as is for example observed in the conrlitions marked by an excessive storage of Mg and Ca in•the extracellular environment.…”

Section: Discussionmentioning

confidence: 88%

Effects of Lithium Administration on Central and Peripheral Nervous System in Rats. Biochemical and Morphological Findings

Scelsi¹,

Arrigoni²,

Moglia³

et al. 1981

Pharmacopsychiatry

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The effect of 4 weeks' treatment with lithium chloride on the central and peripheral nervous system of Wistar albino rats was studied. Normal activity values of some brain enzymes related to energy transduction (LDH, MDH, COX, NADH-ccRT) and neuro-transmission (ACHe), evaluated both in the homogenate in toto and in the crude mitochondrial fraction, were obtained. Fine changes in mitochondrial organelles and nerve processes of neurocytes were ultrastructurally observed. The peripheral nerve studies revealed in some treated rats a slight motor nerve conduction velocity impairment by electro-physiological methods, but no significant alterations in the sciatic nerve specimens examined by electron microscopy.

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Section: Discussionmentioning

confidence: 88%

Effects of Lithium Administration on Central and Peripheral Nervous System in Rats. Biochemical and Morphological Findings

Scelsi¹,

Arrigoni²,

Moglia³

et al. 1981

Pharmacopsychiatry

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“…Namely, the RBC/plasma Li ratio has been reported to be closely connected with the different subtypes of affective disorders (Elizur et al, 1972); with the side effects of Li therapy (Nelson and Cohen, 1976) and with the genetic heterogeneity of the diagnostic subgroups (Mendlewicz et al, 1978). According to other observations, these correlations are inconsistent which can be explained by the large interindividual differences of Li ratios occurring in manic-depressive patients, as has been revealed by several authors (Rybakowski et al, 1974;Lee et al, 1975;Zerbi et al, 1975;Mendlewicz and Verba nek, 1977;Mueller-0erlinghausen, 1977). Furthermore, this intersubjective range might be closely connected with a genetic determination of RBC/plasma Li ratio under both in vivo and in vitro circumstances {Dorns Schless et al, 1975, Pandey et al, 1977.…”

Section: Introductionmentioning

confidence: 96%

Clinical Significance of Sodium-Dependent Lithium Transport in Affective Psychoses

1980

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The steady state red blood cell/plasma lithium (Li) ratios were determined simultaneously with the in vitro rates of sodium-dependent Li transport of erythrocytes during prophylactic Li therapy in 30 unipolar, 52 bipolar forms of manic-depressive patients and in 58 nonmanic-depressive psychiatric patients as a control group. A reciprocal correlation was found between the Li ratios and the values of Na-dependent Li transport. These transport rates were in positive correlation with the steady state Li contents of red blood cells and that of the plasma. Significant differences were revealed between the different nosologic subgroups in the respect of in vitro rates of Na-dependent Li countertransport. Results are discussed in the light of clinical and pharmacogenetic aspects.

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Repression of a lithium pump as a consequence of lithium ingestion by manic-depressive subjects

et al. 1977

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The lithium pump in human erythrocyte membranes, which is responsible for extrusion of lithium against a concentration gradient, has been found to be reversibly repressed during periods of lithium carbonate administration. The pump activity of patients prior to lithium therapy is not different from controls. The onset of repression may require several days to several weeks and occurs at specific individual threshold levels of lithium carbonate dosage. Reactivation of the lithium pump occurs sometime after the dosage is discontinued. We postulate that repression of the lithium pump results from systemically available factors which alter membrane structure, and suggest that is such changes also occur in the central nervous system, they may provide insight into one means by which lithium produces its psychotropic affects.

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Plasma and Erythrocyte Concentrations of Lithium

Cited by 5 publications

References 8 publications

Effects of Lithium Administration on Central and Peripheral Nervous System in Rats. Biochemical and Morphological Findings

Effects of Lithium Administration on Central and Peripheral Nervous System in Rats. Biochemical and Morphological Findings

Clinical Significance of Sodium-Dependent Lithium Transport in Affective Psychoses

Repression of a lithium pump as a consequence of lithium ingestion by manic-depressive subjects

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