Plasma and cerebrospinal fluid concentrations of magnesium in epileptic children

Benga, Ileana; Baltescu, Valeria; Tilinca, Rozalia; Pavel, Octavian Dumitru; Ghiran, Viorel; Muschevici, D; Benga, Gheorghe

doi:10.1016/0022-510x(85)90019-x

Cited by 20 publications

(7 citation statements)

References 14 publications

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“…Indeed, it may account for the occasional failure of VPA to control seizures in some patients. Begna et al (1985) showed that [Mg2+] decreases, although it remains within physiologic values, in plasma and CSF of epileptic children. The action of VPA is due mainly to reduction in voltage-dependent Na+ currents (McLean and Macdonald, 1986;Zona and Avoli, 1990).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, although Mg2+ has been used to suppress seizures (Storchheim, 1993;Pritchard et al, 1984;Dinsdale, 1988), such effects are controversial (Wilson and Vulcano, 1984;Donaldson, 1986;Kaplan et al, 1988). Disturbance of [Mg2+I has been observed in serum or cerebrospinal fluid (CSF) of epileptic patients, but the differences rarely exceeded the physiologic ranges (Hirschfelder and Haury, 1938;Canelas et al, 1965;Breyer and Kanig, 1970;Begna et al 1985;Venkataraman et al, 1987).…”

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confidence: 99%

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Extracellular Magnesium and Anticonvulsant Effects of Valproate in Young Rat Hippocampus

et al. 1995

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Extracellular field potential recordings were made in CA3 subfield of hippocampal slices from rats aged 11-22 days. In these experiments, we analyzed the effects induced by modifying [Mg2+] in the medium (1 or 2 mM) on (a) 4-aminopyridine (4-AP, 50 microM)-induced synchronous events (including ictal- and interictal-like epileptiform discharges as well as gamma-aminobutyric acid (GABA)-mediated potentials), and (b) the changes induced by the antiepileptic drug (AED) valproate (VPA 2 mM) on such activities. Changing [Mg2+] from 1 to 2 mM induced age-dependent effects consisting of reduction in rate of occurrence of ictal-like discharges at 11-13 days (55% reduction, p < 0.005) and 14-16 days (46% reduction, p < 0.025) postpartum. At any age, the rate of occurrence and the amplitude of the GABA-mediated synchronous potentials tended to decrease in 1 mM [Mg2+]. Similar effects were noted when changes in [Mg2+] were made during continuous application of the competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor DL-2-amino-5-phosphonovalerate (APV 50 microM). As previously reported, interictal and ictal discharges were blocked by addition of VPA to medium containing 2 mM [Mg2+]. Such an effect was not observed when [Mg2+] was decreased to 1 mM. In 1 mM, but not in 2 mM [Mg2+], VPA increased the amplitude of GABA-mediated synchronous potentials. Our results indicate that [Mg2+] plays a role in modulating occurrence of 4-AP-induced ictal activity and that it can influence the effects of VPA in this in vitro model of epileptogenesis.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Extracellular Magnesium and Anticonvulsant Effects of Valproate in Young Rat Hippocampus

et al. 1995

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“…It is suggested that these alterations of Mg concentrations in plasma and CSF originate from a functional impairment of the cell membranes, which might occur in epilepsy. 4…”

Section: Introductionmentioning

confidence: 99%

Correlation of serum magnesium levels in febrile convulsions in children: a cross sectional comparative study

Addlur

Khandelwal

Mangajjera

et al. 2021

Int J Contemp Pediatr

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Background: Febrile convulsions is one of the most common type of seizures seen in children. It has been suggested that low serum magnesium (Mg) has occasionally been associated with epilepsy. A positive correlation of the hypomagnesemia with the severity of epilepsy was also found. The present study aimed to estimate the levels of serum magnesium in children with febrile convulsions and to compare serum magnesium levels with normal children.Methods: Fifty patients who were eligible after screening for inclusion and exclusion criteria were included in the study group after a signed written informed consent and 50 controls were also taken. A detailed history, clinical examination and these investigations were done – complete blood count (CBC) (Hb, DC and ESR), serum calcium, serum magnesium, serum electrolytes, random blood sugar and cerebrospinal fluid (CSF) analysis.Results: The serum magnesium level was normal in 45 patients (90%) with febrile convulsions, low levels in 4 cases (8%) and high levels seen in 1 case (2%). Serum magnesium levels were normal in all 50 controls. In this study, the serum magnesium levels has got no correlation in patients with febrile convulsion. So, routine magnesium supplementation need not be prescribed in normal subjects to prevent febrile convulsions.Conclusions: Routine measurement of serum levels of Mg, glucose and calcium are warranted in subject with febrile convulsions. However, large prospective studies are further required in future to establish the correlation of serum Mg and febrile convulsions so that a standard guidelines can be set up which could be followed universally.

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“…In humans, hypomagnesemia can develop as a conse quence of reduced intake, reduced absorption, redistribu tion and increased excretion of magnesium ions [1], Although it is difficult to gain information about Mg2+ deficiency in the organism because intracellular and ex-tracellular concentrations of Mg2+ can vary independently [6], a significant decrease in the concentration of Mg2+ in the plasma was found in epileptics [7], Moreover, a posi tive correlation between the hypomagnesemia and the severity of epilepsy was found: the more severe the epilep sy, the lower was the plasma Mg2+ concentration. Spasmo philic syndromes are also often accompanied by biochem ical changes of Mg2+ metabolism [8], Because of its possi ble therapeutic benefit, the administration of Mg2+ has been recommended in cardiovascular diseases and in psy chiatric disorders [1.6], Magnesium deficiency is characterized by different pathological manifestations: neuromuscular (weakness, tremors, muscle fasciculations), cardiac (arrhythmia, an gina.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Magnesium Deficient Diet on Sleep Organization in Rats

Depoortere¹,

Françon²,

Llopis

1993

Neuropsychobiology

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The influence of magnesium, one of the most important cations in the vertebrate body, on the sleep-wakefulness cycle and ECoG patterns in chronically implanted rats recorded during the light period over a 6-hour period was investigated. Two groups of rats were studied. Group 1 (6 rats): after a control period of 2 weeks, the rats were maintained for 9 weeks on a Mg²⁺-deficient diet. Group 2 (5 rats): after a control period of 2 weeks, the rats were maintained for 7 weeks on a Mg²⁺-deficient diet followed by 4 weeks on a normal diet (recovery period: weeks 8–11). Mg²⁺-deficient diet for 9 weeks induced sleep and ECoG time-dependent alterations. After 6–7 weeks on a Mg²⁺-defi-cient diet (n = 11) sleep analysis showed a significant increase of wakefulness (+50%) at the expense of slow wave sleep (–24%) but paradoxical sleep was not significantly modified. After 9 weeks of a Mg²⁺ deficient diet, sleep was desorganized: light sleep and polyspikes occurred indicating an increase in neuronal excitability. When Mg²⁺ was reintroduced in food and water, sleep organization and ECoG recordings were restored to their original patterns. Our findings which are in line with previous clinical and pharmacological observations provide conclusive arguments for the neuroprotective effect of magnesium ions in neurologic disorders and epileptiform activity. Mg²⁺ deficiency induces ECoG alterations in the rat which bear some similarities with those seen in neurogenic spasmophilic syndromes in man.

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Plasma and cerebrospinal fluid concentrations of magnesium in epileptic children

Cited by 20 publications

References 14 publications

Extracellular Magnesium and Anticonvulsant Effects of Valproate in Young Rat Hippocampus

Extracellular Magnesium and Anticonvulsant Effects of Valproate in Young Rat Hippocampus

Correlation of serum magnesium levels in febrile convulsions in children: a cross sectional comparative study

Effects of a Magnesium Deficient Diet on Sleep Organization in Rats

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