Plasma and aortic lipids in experimental canine atherosclerosis

Butkus, Antanas; Ehrhart, L A; McCullagh, K.G.

doi:10.1016/0014-4800(76)90025-3

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…In contrast to humans, HDL is the predominant lipoprotein and the major cholesterol-carrying compound in dogs (Watson, 1996). However, although this can be associated with cardiac problems in mammals, atherosclerosis in dogs is rare (Vilahur et al, 2011) and has only been achieved experimentally by administering a high-fat/high-cholesterol diet deficient in essential fatty acids (Butkus et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

Effect of lactose-free milk powder on lactose intolerance symptoms and nutritional status of pet dogs

Wang

Lou

Turpeinen

et al. 2022

JAAN

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The effects of standard cow, goat and lactose-free cow milk powder on lactose intolerance symptoms and the nutritional status of dogs was studied. Forty adult Springer Spaniels with lactose intolerance were randomly allocated into four groups with ten dogs each and fed one of the milk powders or water for 21 d. The milk powders were reconstituted daily by diluting 10 g milk powder to 60 g water and 2 g milk powder/kg body weight was provided ad libitum and refusals were monitored daily. Lactose intolerance was assessed by faecal composition and pH, water and lactose contents. Biochemical markers for nutritional status were analysed. Feeding intolerance and lactose in faecal samples were observed in dogs fed the standard cow and goat milk powder, but not for the lactose-free milk powder or control groups. The high- and low-density lipoprotein cholesterol increased in all milk powder groups, while there were no other differences in nutritional status measurement. The results suggested that feeding lactose-free milk powder to dogs with lactose intolerance reduced the occurrence of symptoms, thereby enhancing the health and wellbeing of dogs.

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Section: Discussionmentioning

confidence: 99%

Effect of lactose-free milk powder on lactose intolerance symptoms and nutritional status of pet dogs

Wang

Lou

Turpeinen

et al. 2022

JAAN

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“…Spontaneous atherosclerosis is rare in dogs; even a high cholesterol diet does not result in the development of advanced atherosclerotic lesions (Mahley et al, 1974). However, induction of experimental atherosclerosis in dogs is possible with the use of a high fat/high cholesterol (up to 5% w/w) diet deficient in essential fatty acids (Mahley et al, 1974;Butkus et al, 1976). Hypercholesterolemia and atherosclerosis can also be induced in foxhounds by dietary means (Kent and Whitney, 1982), though a poor response to dietary cholesterol limits further study (Narayanaswamy et al, 2000).…”

Section: Dogsmentioning

confidence: 99%

Animal models for the atherosclerosis research: a review

et al. 2011

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“…However, induction of experimental atherosclerosis in dogs has been achieved by administering high-fat/high-cholesterol diet deficient in essential fatty acids [87]. …”

Section: Canine Models Of Atherosclerosis and Thrombosismentioning

confidence: 99%

Atherosclerosis and Thrombosis: Insights from Large Animal Models

Vilahur

Padró

Badimon

2011

BioMed Research International

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Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. The combination of in vitro, ex vivo, and in vivo experimental approaches has largely contributed to a better understanding of the mechanisms underlying the atherothrombotic process. Indeed, different animal models have been implemented in atherosclerosis and thrombosis research in order to provide new insights into the mechanisms that have already been outlined in isolated cells and protein studies. Yet, although no model completely mimics the human pathology, large animal models have demonstrated better suitability for translation to humans. Indeed, direct translation from mice to humans should be taken with caution because of the well-reported species-related differences. This paper provides an overview of the available atherothrombotic-like animal models, with a particular focus on large animal models of thrombosis and atherosclerosis, and examines their applicability for translational research purposes as well as highlights species-related differences with humans.

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Plasma and aortic lipids in experimental canine atherosclerosis

Cited by 7 publications

References 17 publications

Effect of lactose-free milk powder on lactose intolerance symptoms and nutritional status of pet dogs

Effect of lactose-free milk powder on lactose intolerance symptoms and nutritional status of pet dogs

Animal models for the atherosclerosis research: a review

Atherosclerosis and Thrombosis: Insights from Large Animal Models

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