Plasma Amino Acid Response to Ingestion of L-Amino Acids and Whole Protein

Gropper, Sareen S.; Gropper, Daniel M.; Acosta, Phyllis B.

doi:10.1097/00005176-199302000-00008

Cited by 63 publications

(37 citation statements)

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“…After ingestion of an AA mixture in healthy subjects there was an increase in plasma AA concentration which is in agreement with data derived from other studies worldwide [4][5][6]. Following the ingestion of AA mixture in one single dose there was also an increase in insulin and a decrease in glucose which caused the clinical side-effects observed in the test persons• Surprisingly, this postprandial hypoglycaemia which was less marked after ingestion of AA mixture in smaller portions was not observed in the case of the 9-year-old PKU boy.…”

Section: Discussionsupporting

confidence: 92%

Utilisation of amino acid mixtures in adolescents with phenylketonuria

et al. 1996

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The nutritional regimen of patients with phenylketonuria (PKU) comprises a diet of natural proteins and phenylalanine (Phe)-free amino acid (AA) mixture. The main daily protein requirement is covered by a Phe-free AA mixture. In an adult with PKU, the consumption of the daily AA requirement in one single dose at breakfast caused nausea and vomiting. Therefore, four studies were designed to investigate the adverse and metabolic effects resulting from large intakes of AA mixtures used in the treatment of PKU patients with respect to the following: (1) biochemical effects following consumption of one single dose of Phe-free AA mixture in healthy persons; (2) transient metabolic changes caused by different individual regimens of AA intake in healthy persons and in one PKU patient; (3) nitrogen excretion in PKU patients taking the AA mixture in two or three portions; and (4) catabolic metabolism of AA in a PKU patient. In healthy subjects following the ingestion of the AA mixture in one bolus there was an increase in the blood levels of the given AA and also an increase in blood insulin concentration and a decrease in blood glucose concentration. These changes were less marked when the AA mixture was divided into three portions per day. In contrast, in a PKU patient following the ingestion of AA there was an increase in blood glucose. The urinary nitrogen excretion was greater in PKU patients when one compared to three portions of AA mixture was taken. The consumption of the daily requirement of AA mixture in one single does produced increased catabolism in a PKU patient. In conclusion it is recommended that the total daily amount of AA mixture should be divided into a minimum of three portions.

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Section: Discussionsupporting

confidence: 92%

Utilisation of amino acid mixtures in adolescents with phenylketonuria

et al. 1996

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“…Basic amino acid peaks in the blood were reached more slowly at the 65th min, and Cit the last at the 80th min. These delays are in accordance with those reported by Gropper et al (1993) for amino acids in P following ingestion of L-amino acids or whole protein.…”

Section: Kinetics Of Amino Acid Concentrations In P and Esupporting

confidence: 91%

Erythrocytes participate significantly in blood transport of amino acids during the post absorptive state in normal humans

Agli

Schaefer

Gény

et al. 1998

European Journal of Applied Physiology

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To investigate the participation of erythrocytes in the blood transport of amino acids during the course of intestinal absorption in humans, erythrocyte and plasma amino-acid concentrations were determined following ingestion of an oral load of amino acids. In addition to baseline plasma and erythrocyte amino acid concentrations in 18 subjects, plasma and erythrocyte amino acids kinetics during the 125 min following an oral amino acid load were further determined in 9 of the 18 subjects. The results showed that human erythrocytes contained most amino acids at similar or higher concentrations than plasma. Furthermore, the correlations observed between plasma and erythrocyte contents clearly indicated that erythrocytes were involved in the transport of amino acids by the blood. For some amino acids erythrocyte transport sometimes exceeded that of plasma. Significant correlation coefficients showed that strong plasma-erythrocyte relationships existed for alanine, valine, methionine, isoleucine, leucine, phenylalanine, and ornithine. In conclusion, our data supported the hypothesis that both blood compartments, plasma and erythrocytes, are involved significantly in the blood transport of amino acids in humans during the postabsorptive state.

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“…When infants are receiving peptides or free amino acids, the highest postprandial plasma amino acid concentrations appear earlier and, consequently, lower levels may occur 3 h postprandially if compared to infants receiving proteins [2,8]. Since the aim of the study was to compare LBW infants at similar energy and protein intakes, the concentration of the whey protein hydrolysate fortifier used in the study was 20% lower than that recommended [23] which may also axplain in part the lower concentrations of some essential amino acids.…”

Section: Discussionmentioning

confidence: 99%

“…LBW = low birth weight cure such high growth rates in LBW infants, different methods of fortification of human milk with human milk protein [2,8,12] have been recommended. Considering the practical difficulties in obtaining human milk proteins for fortification, additives based on cow's milk proteins [4,10,16] or hydrolysates [14,21] have been developed.…”

Section: Introductionmentioning

confidence: 99%

Protein quality of human milk fortifier in low birth weight infants: Effects on growth and plasma amino acid profiles

Boehm¹,

Borte²,

Bellstedt

et al. 1993

Eur J Pediatr

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Serum preprandial essential amino acid, urea and prealbumin concentrations, and growth rates were studied in appropriate for gestational age low birth weight infants fed one of three regimens: (1) human milk enriched with human milk protein (n = 17); (2) bovine whey protein hydrolysate (n = 18; and (3) a mixture of bovine proteins, peptides and amino acids designed to have an amino acid composition close to that of human milk proteins (n = 18). Energy and nitrogen intakes were similar in all groups. Growth rates and gross metabolic responses did not differ between the feeding groups. There were also no differences in the amino acid profiles between those infants fed human milk protein fortifier and mixed bovine protein fortifier. Infants fed the whey fortifier had significantly higher threonine concentrations in comparison to those fed exclusively human milk protein (287 +/- 63 mumol/l vs 168 +/- 26 mumol/l) whereas the levels of some other essential amino acids (i.e. valine, leucine, lysine, histidine, phenylalanine and tryptophan) were lower. The results indicate that growth rates and gross metabolic indices do not depend on the protein quality of human milk fortifiers. However, the addition of well balanced mixtures of bovine proteins to human milk results in amino acid profiles similar to those observed in LBW infants fed similar amounts of human milk proteins.

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Plasma Amino Acid Response to Ingestion of L-Amino Acids and Whole Protein

Cited by 63 publications

References 0 publications

Utilisation of amino acid mixtures in adolescents with phenylketonuria

Utilisation of amino acid mixtures in adolescents with phenylketonuria

Erythrocytes participate significantly in blood transport of amino acids during the post absorptive state in normal humans

Protein quality of human milk fortifier in low birth weight infants: Effects on growth and plasma amino acid profiles

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