Plasma Amino Acid Response Curve and Amino Acid Requirements in Young Men: Valine and Lysine

Young, Vernon R.; Tontisirin, Kraisid; Ozalp, I; Lakshmanan, Florence Lazicki; Scrimshaw, Nevin S.

doi:10.1093/jn/102.9.1159

Cited by 67 publications

(11 citation statements)

References 42 publications

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“…Similar results were also found in subjects receiving low levels of wheat gluten. fi ndings are consistent with the report of YOUNG et al (21) that the concentration of plasma lysine, unlike those of valine and other EAAs, was not correlated with a decrease in lysine intake below 7mg/kg. We also found that a protein-free diet had very little effect on the plasma concentration of lysine, as reported by others (9,11), and observed in young men on a diet containing a lysine-free amino acid mixture (21).…”

Section: Discussionsupporting

confidence: 92%

“…fi ndings are consistent with the report of YOUNG et al (21) that the concentration of plasma lysine, unlike those of valine and other EAAs, was not correlated with a decrease in lysine intake below 7mg/kg. We also found that a protein-free diet had very little effect on the plasma concentration of lysine, as reported by others (9,11), and observed in young men on a diet containing a lysine-free amino acid mixture (21). As is well known, when growing animals were given a gluten diet, their plasma lysine concentration decreases to a very low level and increases again when lysine is added to the diet (5,22).…”

Section: Discussionsupporting

confidence: 92%

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Effect of low protein diets on free amino acids in plasma of young men: Effect of wheat gluten diet.

Fujita

Yamamoto

Rikimaru

et al. 1979

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryStudies were made on alterations in plasma amino acids in young men fed a diet containing graded levels of wheat gluten. After one week on a standard diet containing 200mgN/kg of mixed protein (animal protein content 45%), 38 young men were given a wheat gluten diet containing 170, 100, 60, 30, 15 or zero mgN/kg for 2 weeks. Blood samples measuring plasma free amino acids were taken before breakfast at the end of the periods on a standard diet and an experimental diet. In subjects on diets containing 170 to 30mgN/kg the plasma concentrations of threonine, valine, methionine, leucine, tyrosine, phenylalanine, serine, histidine and arginine fell significantly with decrease in protein intake, but

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Effect of low protein diets on free amino acids in plasma of young men: Effect of wheat gluten diet.

Fujita

Yamamoto

Rikimaru

et al. 1979

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…When the given amino acid intake exceeds the requirement level, it increases linearly with increasing intake of the given amino acid. The point where it begins to increase agrees well with amino acid requirements determined by growth response in rats [8], broilers [17] and chicks [22], the egg production rate in laying hens [19] and nitrogen balance tests in pigs [9] and young men [21].…”

supporting

confidence: 70%

Response of Plasma Concentration of Free Amino Acid to Change of Dietary Protein and Amino Acid Levels in Adult Thoroughbreds

Takagi¹,

Yonemochi²,

Hashimoto³

et al. 2004

JES

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“…Although whole blood rather than plasma was prepared for amino acid analysis in the studies presented, it is unlikely that this factor accounted for our inability to reproduce the observations of Young et al (9,10). Snyderman et al (5) have shown that increasing protein intake causes a proportionate rise in the free amino acids of plasma and red blood cells.…”

Section: Normal Fastingmentioning

confidence: 82%

Design and Evaluation by Nitrogen Balance and Blood Aminograms of an Amino Acid Mixture for Total Parenteral Nutrition of Adults with Gastrointestinal Disease

Anderson¹,

Patel²,

Jeejeebhoy³

1974

J. Clin. Invest.

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A B S T R A C T This study was undertaken to assess the efficacy of an anmino acid mixture formulated for initravenious use from estimates of requirements for essential amino acids of human adults, and from data previously derived from a study using casein hydrolysate as the amino acid source. This mixture contained 39.4% essential amino acids, with glycine, alanine, arginine, histidine, andl proline selected to supply the nonessential nitrogen.Nitrogen balance and blood aminograms were measured in six adult patients with gastrointestinal disease, fed intravenously for 1 wk at each of three levels of amino acid intake, while all other nutrients were constant and adequate in relation to body weiglht. Four of the patients were then fed 1.0 g/kg of egg or meat protein orally for 1 wk at the end of the 3 wk study, while all nutrients other than the amino acids were fed intravenously. Average nitrogen balances of -0.8, 0.5, and 2.2 g/day were observed when the amounts of amino acids infused were 0.25, 0.5, and 1.0 g/kg, respectively. Fasting levels of threonine, glycine, cystine, methionine, isoleucine, tryptophan, and arginine, but not of the other amino acids, increased with the increment in input, although the levels were generally lower than normal. The increase in blood concentration observed during infusion was similar for each of the essential amino acids, indicating that the supply of each of the amino acids was much better balanced for utilization than casein hydrolysate. However the blood aminograms did suggest that some changes in composition of the mixture for the malnourished adult were desirable, such that the amino acid mixture resembled that needed by the normal growing child. Nitrogen balance in the four patients fed orallyThis work was presented in part at the IX International

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Plasma Amino Acid Response Curve and Amino Acid Requirements in Young Men: Valine and Lysine

Cited by 67 publications

References 42 publications

Effect of low protein diets on free amino acids in plasma of young men: Effect of wheat gluten diet.

Effect of low protein diets on free amino acids in plasma of young men: Effect of wheat gluten diet.

Response of Plasma Concentration of Free Amino Acid to Change of Dietary Protein and Amino Acid Levels in Adult Thoroughbreds

Design and Evaluation by Nitrogen Balance and Blood Aminograms of an Amino Acid Mixture for Total Parenteral Nutrition of Adults with Gastrointestinal Disease

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