Plasma amino acid profiles during the first three days of life in infants with respiratory distress syndrome: Effect of parenteral amino acid supplementation

Rivera, Audelio; Bell, Edward F.; Stegink, Lewis D.; Ziegler, Ekhard E.

doi:10.1016/s0022-3476(89)80858-3

Cited by 28 publications

(12 citation statements)

References 13 publications

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“…acids in low birth weight infants during the first 3 d of life are limited (2,3). Utilization of intravenously infused amino acids has been studied in older and more stable infants by nitrogen balance (4,5).…”

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confidence: 99%

Effect of Intravenous Amino Acids on Protein Metabolism of Preterm Infants during the First Three Days of Life

1993

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confidence: 99%

Effect of Intravenous Amino Acids on Protein Metabolism of Preterm Infants during the First Three Days of Life

1993

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“…Their arginine results did not differ significantly from the cohort. Nevertheless, Kavvadia/Greenough/Lilley/Laubscher/ Dimitriou/Boa/Poyser an arginine level of !30 Ìmol/l would be below most of the ranges quoted for the first few days of life [12][13][14] or at birth [15][16][17]. Equally important, in both groups, certain babies had arginine levels in excess of 30 Ìmol/l which emphasizes that low levels cannot be assumed in an infant with suspected PHN.…”

Section: Discussionmentioning

confidence: 82%

“…A number of infants in each group had low arginine levels. A variety of reference ranges for arginine levels are given in the literature and differ according to the maturity of the population studied [12], their postnatal age [13], and whether they had been enterally [22] or parenterally [23] fed. A small number of infants had either received total parenteral nutrition or have been born growth retarded.…”

Section: Discussionmentioning

confidence: 99%

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Plasma Arginine Levels and the Response to Inhaled Nitric Oxide in Neonates

Kavvadia

Greenough²,

Lilley³

et al. 1999

Neonatology

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Inhaled nitric oxide (iNO) can be an effective vasodilator in pulmonary hypertension of the newborn (PHN). The aim of this study was to determine whether differences in arginine levels, from which endogenous NO is produced, explain the variability in response to NO and whether the arginine levels were lower in term and preterm infants with PHN than in infants without PHN (controls). We prospectively studied 30 infants (17 born preterm) with clinically diagnosed PHN and treated with iNO and 22 controls (14 born preterm). Three NO levels (10, 20, 40 ppm) were administered to the PHN infants to identify that associated with maximum oxygenation. Twenty-seven infants with PHN improved following iNO and had lower arginine levels than those infants who did not respond to iNO (p < 0.05). No significant relationship, however, was noted between the arginine levels and either the magnitude of change in the oxygenation index in response to iNO or the NO level associated with maximum oxygenation. The median plasma arginine level prior to iNO of the PHN infants was 12.5 (range 2–53) μmol/l, but not significantly lower than that of the controls (median 24, range 3–82 μmol/l). We conclude that differences in plasma arginine levels are unlikely to explain the variation in response to iNO and that, although arginine levels tended to be lower in infants with PHN, this is not a consistent finding in either the term or preterm infants.

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“…[1][2][3][4][5] Without the provision of exogenous AA after delivery, the extremely low birth weight (ELBW) infant will become catabolic, losing as much as 1% of protein stores daily because of on-going proteolysis. 6 Despite an increasing body of literature that supports the provision of intravenous AA within hours of birth to prevent this proteolysis, [7][8][9][10][11][12] practices continue to vary across nurseries in the United States because of concerns about metabolic capabilities of the ELBW infant.…”

Section: Introductionmentioning

confidence: 99%

Early amino acids and the metabolic response of ELBW infants (⩽1000 g) in three time periods

2009

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Objective: To evaluate early amino-acid (AA) administration in extremely low birth weight (ELBW) infants over three time periods, beginning with the initiation of this strategy. Study design:This was a retrospective study of ELBW infants between 2000 and 2007. Nutritional intake and laboratory results were monitored during the first 5 days of life. Growth rates and complications were followed until discharge.Result: Infants were similar in birth weight (BW), gestational age (GA) and severity of illness. The age at initiation of AA decreased significantly over time. Age at weight nadir, return to BW and percent postnatal weight loss decreased in epoch 3. There were modest increases in blood urea nitrogen (BUN), but no significant metabolic disturbances were observed. Cholestasis was more prevalent in epoch 2.Conclusion: AA administration within the first hours of life appears to be safe and beneficial for ELBW infants. Absent signs of renal dysfunction, a modest rise in BUN is consistent with the neonate's utilization of AAs for energy.

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Plasma amino acid profiles during the first three days of life in infants with respiratory distress syndrome: Effect of parenteral amino acid supplementation

Cited by 28 publications

References 13 publications

Effect of Intravenous Amino Acids on Protein Metabolism of Preterm Infants during the First Three Days of Life

Effect of Intravenous Amino Acids on Protein Metabolism of Preterm Infants during the First Three Days of Life

Plasma Arginine Levels and the Response to Inhaled Nitric Oxide in Neonates

Early amino acids and the metabolic response of ELBW infants (⩽1000 g) in three time periods

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