Plasma amino acid concentrations in healthy elderly men and women

Caballero, Benjamı́n; Gleason, Ray E.; Wurtman, Richard J.

doi:10.1093/ajcn/53.5.1249

Cited by 67 publications

(48 citation statements)

References 24 publications

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“…Before TP depletion, the plasma TP concentrations reported for women were approximately half that of the men, and following TP depletion they were 5-fold lower. Differences of these magnitudes between the sexes have never before been reported by other investigators (Caballero et al 1991;Delgado et al 1989;Lucini et al 1996;Maes et al 1995;Møller et al 1996;Neumeister et al 1997) or in previous studies conducted by the authors themselves (Benkelfat et al 1994;Ellenbogen et al 1996).…”

Section: Discussionmentioning

confidence: 64%

Brain Serotonin Synthesis Rates in Rhesus Monkeys Determined by [11C]α-Methyl-?-Tryptophan and Positron Emission Tomography Compared to CSF 5-Hydroxyindole-3-Acetic Acid Concentrations

Shoaf

Carson

Hommer

et al. 1998

Neuropsychopharmacology

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Twelve male, fasted, anesthetized rhesus monkeys were studied with positron emission tomography (PET) and [ C] ␣ -methyl-L -tryptophan ( ␣ MTP) to determine serotonin synthesis rates as described by Diksic et al. (1991) (Nishizawa et al. 1997) and dogs (Diksic et al. 1991) Early attempts to determine serotonin synthesis rates in small mammals usually involved pharmacological manipulation of the serotonin system followed by the sampling of brain tissue for the determination of tryptophan, tryptophan metabolites, serotonin, and/or serotonin metabolites. These studies were limited by the ability of the investigator to isolate specific brain regions, and the sensitivity of the assays usually required the pooling of tissues from multiple animals (Colmenares et al. 1975;Curzon and Marsden 1975;Fernstrom and Wurtman 1971; From the Laboratory of Clinical Studies (SES, DH, WW, JDH, ML), DICBR, National Institute on Alcohol Abuse and Alcoholism, Bethesda; and the PET Department (RC, BS, PH, WE), National

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Section: Discussionmentioning

confidence: 64%

Brain Serotonin Synthesis Rates in Rhesus Monkeys Determined by [11C]α-Methyl-?-Tryptophan and Positron Emission Tomography Compared to CSF 5-Hydroxyindole-3-Acetic Acid Concentrations

Shoaf

Carson

Hommer

et al. 1998

Neuropsychopharmacology

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“…The intracellular pool of amino high-protein meals for a few days) [27], higher caloric intake [28], body mass index (lower in obesity) [29], age (lower in older men) [30] and gender (higher in males) [31]. Plasma tryptophan concentrations are readily increased by administering exogenous tryptophan.…”

Section: Discussionmentioning

confidence: 99%

Plasma concentration of tryptophan and pregnancy-induced hypertension

Grafka

Łopucki

Karwasik-Kajszczarek

et al. 2018

Arterial Hypertension

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Introduction. Pregnancy-induced hypertension (PIH) is one of the main clinical problems of unexplained etiopathogenesis. New factors involved in the pathogenesis of this disease are still being searched. The available literature lacks data regarding the differences in tryptophan concentrations in physiological and PIH-complicated pregnancy. Previous studies have shown that L-tryptophan treatment reduces blood pressure in hypertensive rats. The direct vascular effects of tryptophan have not been fully explored. In this study, the stimulating effect of tryptophan on the development of PIH was revealed. The aim of the present study was to assess the differences in plasma tryptophan concentrations in physiological pregnancies and pregnancies complicated with hypertension in the third trimester. Material and methods. The study was carried on 105 complicated by PIH and 105 pregnant women with blood pressure within normal limits between 25 and 41 weeks of gestation. Tryptophan concentration was determined by the automated ion-exchange chromatography using an Amino Acid Analyser (AAA 400) by Ingos, Czech Republic. Tryptophan concentration was expressed in μmol/cm 3 plasma. Results. The mean concentration of tryptophan in the third trimester of physiological pregnancy was found to be 0.035 ± 0.009 μmol/cm

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“…In addition, in adults they are used primarily in the assessment of nutritional status (4)(5)(6)(7). In recent years, the importance of nutritional status in patients with chronic renal or liver disease has been emphasized by studies that relate malnutrition with increased morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Biological variation of free plasma amino acids in healthy individuals

Corte

Venta²

2009

Clinical Chemistry and Laboratory Medicine

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Background: Biological variation data for free plasma amino acids are lacking from the more comprehensive databases. Therefore, we determined the intra-and inter-individual components of variation in healthy subjects. These data were used to define desirable goals for imprecision, bias and total error, indices of individuality and reference change values. Methods: Plasma samples were collected from 11 volunteers at weekly intervals over 5 weeks. Free plasma amino acids were analyzed by reversed-phase HPLC and analytical and biological variation data were derived using ANOVA. Results: Intra-individual coefficients of variation ranged from 9.5% to 46.4%, with lower values among the essential amino acids. The mean inter-individual coefficient of variation was 46.6% and was higher than intra-individual values for all amino acids. Thus, indices of individuality were below 0.8. Reference change values ranged from 30.9% to 128.4% and total error values ranged from 15.2% to 61.0%. Conclusions: Plasma amino acids exhibit relatively low intra-individual coefficients of variation, with essential amino acids showing tighter homeostatic control. Analytical quality goals can be reasonably achieved with current methods. Reference intervals are of limited value in the detection of unusual results in an individual. Therefore, comparison of serial results by means of the reference change values is recommended. Clin Chem Lab Med 2010;48:99-104.

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Plasma amino acid concentrations in healthy elderly men and women

Cited by 67 publications

References 24 publications

Brain Serotonin Synthesis Rates in Rhesus Monkeys Determined by [11C]α-Methyl-?-Tryptophan and Positron Emission Tomography Compared to CSF 5-Hydroxyindole-3-Acetic Acid Concentrations

Brain Serotonin Synthesis Rates in Rhesus Monkeys Determined by [11C]α-Methyl-?-Tryptophan and Positron Emission Tomography Compared to CSF 5-Hydroxyindole-3-Acetic Acid Concentrations

Plasma concentration of tryptophan and pregnancy-induced hypertension

Biological variation of free plasma amino acids in healthy individuals

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