Plasma Alkylresorcinol Metabolite, a Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Type 2 Diabetes and Impaired Glucose Regulation in a Chinese Population

Sun, Taoping; Rong, Yuluo; Hu, Xiaoli; Zhu, Yalun; Huang, Hao; Chen, Liangkai; Li, Peiyun; Li, Shuzhen; Yang, Wei; Cheng, Jinquan; Yang, Xuefeng; Yao, Ping; Hu, Frank B.; Liu, Liegang

doi:10.2337/dc17-1570

Cited by 31 publications

(16 citation statements)

References 35 publications

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“…The study population consisted of 1,938 newly diagnosed T2D patients. As we previously described [15], the patients were consecutively recruited from those attending for the first time the outpatient clinics of the Department of Endocrinology, Tongji Medical College Hospital, Wuhan, China, from January 2009 to June 2016. The inclusion criteria were age !30 years, body mass index (BMI) <40 kg/m 2 , without history of a diagnosis of diabetes, and without history of receiving pharmacological treatment for hyperlipidemia or hypertension.…”

Section: Study Populationmentioning

confidence: 99%

Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis

Rong

Wang

et al. 2021

Diabetes Research and Clinical Practice

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Circulating uric acid levels were associated with insulin resistance, but the causality is unclear. We aimed to investigate the association between plasma uric acid and insulin resistance in newly diagnosed type 2 diabetes (T2D). Methods: We enrolled 1,938 patients who underwent a 75-g oral glucose tolerance test. Insulin resistance was estimated based on the homeostatic model assessment index (HOMA2-IR) and the Matsuda index. Uric acid was measured in fasting plasma by uricase-peroxidase method. We genotyped single nucleotide polymorphisms (SNPs) that were recently identified as top hits in genome-wide association studies of uric acid levels. A weighted genetic risk score (wGRS) was calculated based on the associations between selected SNPs and uric acid levels. Results: The adjusted b coefficients for Ln-transformed Matsuda index and HOMA2-IR per 1 mg/dL uric acid increment were À0.070 (95%CI: À0.089, À0.052) and 0.057 (95%CI: 0.039, 0.075). These associations were more pronounced among women than men. In Mendelian randomization analysis, the wGRS raised uric acid by 0.225 mg/dL (95%CI: 0.138, 0.312) per SD increase of the score. However, no association was observed between the wGRS and insulin resistance indices whether in men or women. Conclusions: Elevated plasma uric acid was associated with higher risk of insulin resistance, along with observation of gender difference in such association. However, our study does not support a causal role of plasma uric acid on insulin resistance among newly diagnosed T2D patients.

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Section: Study Populationmentioning

confidence: 99%

Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis

Rong

Wang

et al. 2021

Diabetes Research and Clinical Practice

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“…() if all wheat would be processed by refined milling for human consumption, 150 million tons of bran would be produced per year. Growing evidence indicates that bran intake reduces the risk of some chronic diseases in modern society (Aune et al ., ), including different forms of cancer (Makarem et al ., ), type 2 diabetes (Taoping Sun et al ., ), cardiovascular disease (Aune et al ., ), and obesity (Albertson et al ., ), owing to its high contents of dietary fibre, micronutrients, and phytochemicals (Vitaglione et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Effects of aleurone‐rich fraction on the hydration and rheological properties attributes of wheat dough

Fen

et al. 2018

Int J of Food Sci Tech

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This study aimed to evaluate the effects of incorporation of aleurone-rich fraction (ALF) on the hydration and rheological properties of wheat dough. Incorporation of ALF significantly increased water absorption (P < 0.05) and competition for water in dough was observed. Peak viscosity, through viscosity, and final viscosity decreased with the amount of ALF added (P < 0.05), whereas 20% ALF had stronger gel ability than whole-wheat flour. Dynamic rheological experiments revealed ALF blend dough were more stable than whole-wheat dough, which was in accord with the higher dough stability and strength observed in Mixolab. Scanning electron microscopy showed that disruption of gluten network with ALF incorporation, whereas 20% ALF showed better stability dough structure than the whole-wheat dough. Considering those influences on dough properties, the 20% ALF seems to be a promising substitute for whole-wheat flour to producing dietary fibre-rich products.

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“…Our study has several strengths. Firstly, we objectively determined concentration of plasma DHPPA, which appears to be a biomarker of whole-grain wheat and rye intake and has been used in several studies to assess whole-grain wheat and rye intake (19,22). Compared with dietary recording methods, the measurement of plasma DHPPA concentration seems to be more objective and independent.…”

Section: Discussionmentioning

confidence: 99%

“…Intact alkylresorcinols and their 2 main end-products-3,5dihydroxybenozoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA)-are measurable in plasma (15,17). Recently, alkylresorcinols and their metabolites have been suggested as biomarkers of whole-grain rye and wheat intake (18), and they have been used to assess whole-grain rye and wheat intake in several epidemiological studies (19,20). Considering that the half-life of DHPPA (16.3 hours) is signi cantly longer than that of DHBA (10.1 hours) and alkylresorcinols (5 hours) and blood samples are usually taken after overnight fasting, plasma DHPPA appears to be a good and speci c biomarker of whole-grain wheat and rye intake (21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Plasma Alkylresorcinol Metabolite, A Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Metabolic Syndrome: A Case-Control Study

Zhou

Wang

et al. 2020

Preprint

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Background: Whole-grain intake assessed through dietary recording methods has been suggested to be inversely associated with the metabolic syndrome (MetS) risk in several epidemiological studies. However, limited studies have evaluated the association between whole-grain intake and MetS risk when using objective biomarkers of whole-grain intake. The aim of this study was to examine the association between plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, and MetS risk in a Chinese population.Methods: A case-control study of 667 MetS cases and 667 matched controls was conducted based on baseline data of the Tongji-Ezhou Cohort study. Plasma DHPPA concentrations were assessed by high-performance liquid chromatography-tandem mass spectrometry. MetS was determined using definition of the Joint Interim Statement.Results: Plasma DHPPA was inversely associated with MetS risk. After adjustment for age, sex, body mass index, smoking status, alcohol drinking status, physical activity and education level, the odds ratios (ORs) for MetS across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.86 (0.58-1.26), 0.77 (0.52-1.15), and 0.59 (0.39-0.89), respectively. The inverse relation between plasma DHPPA and MetS persisted in stratified analyses according to confounding factors. In addition, the cubic spline analysis revealed a potential nonlinear association between plasma DHPPA and MetS, with a steep reduction in the risk at the lower range of plasma DHPPA concentration.Conclusions: Our study revealed that higher plasma DHPPA concentrations were associated with lower odds of MetS. Our findings provided further evidence to support health benefits of whole grain consumption.

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Plasma Alkylresorcinol Metabolite, a Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Type 2 Diabetes and Impaired Glucose Regulation in a Chinese Population

Abstract: These findings suggested that higher plasma DHPPA concentrations were associated with lower odds of T2D and IGR. Further studies are warranted to confirm these findings in prospective cohorts.

Cited by 31 publications

References 35 publications

Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis

Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis

Effects of aleurone‐rich fraction on the hydration and rheological properties attributes of wheat dough

Plasma Alkylresorcinol Metabolite, A Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Metabolic Syndrome: A Case-Control Study

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