Plasma adrenomedullin level in children with obesity: relationship to left ventricular function

Metwalley, Kotb Abbass; Farghaly, Hekma Saad; Sherief, Tahra

doi:10.1007/s12519-017-0106-6

Cited by 11 publications

(10 citation statements)

References 49 publications

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“…High levels of circulating pro-ADM have been shown to predict clinical outcomes and survival (24,25). Increased pro-ADM levels found in obesity (14,15,26) may reflect disease severity, including cardiovascular or renal diseases as well as insulin resistance related to obesity. The increased ADM levels in obesity may suggest that ADM has a protective role against obesity complications.…”

Section: Discussionmentioning

confidence: 99%

Adrenomedullin Attenuates Inflammation in White Adipose Tissue of Obese Rats Through Receptor‐Mediated PKA Pathway

Dai

Wang

Kang

et al. 2020

Obesity

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Objective: Adrenomedullin (ADM) possesses therapeutic potential for inflammatory diseases. Consequently, the effects of ADM on inflammation in visceral white adipose tissue (vWAT) of obese rats or in adipocytes were explored in this study. Methods: Male rats were fed a high-fat diet for 12 weeks to induce obesity, and obese rats were implanted with osmotic minipumps providing constant infusion of ADM (300 ng/kg per hour) and continued to be fed a high-fat diet for 4 weeks. Results: When compared with the control group, endogenous protein expression of ADM and ADM receptors in vWAT and in lipopolysaccharide (LPS)-treated adipocytes was markedly increased. ADM significantly decreased the protein expression of the inflammatory mediators TNFα, IL-1β, cyclooxygenase-2, and inducible nitric oxide synthase in vWAT of obese rats and in adipocytes stimulated by LPS. It also inhibited the activation of the inflammatory signaling pathways MAPK and NF-κB induced by LPS in adipocytes. These effects of ADM in adipocytes were inhibited by the administration of ADM receptor antagonist and cAMP-dependent protein kinase (PKA) activation inhibitor. Conclusions: ADM can inhibit inflammation in WAT in obesity, which may be mediated by the activation of ADM receptors and PKA.

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Section: Discussionmentioning

confidence: 99%

Adrenomedullin Attenuates Inflammation in White Adipose Tissue of Obese Rats Through Receptor‐Mediated PKA Pathway

Dai

Wang

Kang

et al. 2020

Obesity

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“…In this same article, a cut-off value of ADM at 52 pg/mL is proposed to differentiate obese children with and without left ventricular hypertrophy, yielding a sensitivity of 94.32% and specificity of 92.45%. Thus, measuring plasma ADM levels in obese children may help to identify those at high risk of developing LV hypertrophy and dysfunction [ 69 ].…”

Section: Resultsmentioning

confidence: 99%

A Review of Adrenomedullin in Pediatric Patients: A Useful Biomarker

2022

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Adrenomedullin has several properties. It acts as a potent vasodilator, has natriuretic effects, and reduces endothelial permeability. It also plays a role in initiating the early hyperdynamic phase of sepsis. Since its discovery, many articles have been published studying the uses and benefits of this biomarker. The aim of this review is to determine the usefulness of adrenomedullin in pediatric patients. Relevant studies covering adrenomedullin in pediatrics (<18 years) and published up until August 2021 were identified through a search of MEDLINE, PubMed, Embase, Web of Science, Scopus, and Cochrane. Seventy studies were included in the present review, most of them with a low level of evidence (IV to VI). Research on adrenomedullin has primarily been related to infection and the cardiovascular field. The performance of adrenomedullin to quantify infection in children seems satisfactory, especially in sepsis. In congenital heart disease, this biomarker seems to be a useful indicator before, during, and after cardiopulmonary bypass. Adrenomedullin seems to be useful in the pediatric population for a large variety of pathologies, especially regarding infection and cardiovascular conditions. However, it should be used in combination with other biomarkers and clinical or analytical variables, rather than as a single tool.

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“…It has been reported that there is an increased plasma ADM level in people with obesity [24,25], and ADM might derive from many other organs or tissues, such as WAT. This increase could be a compensatory response of the body.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, ADM reduces oxidative stress in injured cerebral tissue of rats [22] and inhibits inflammation of vascular endothelial cells of rats [23]. People with obesity display an obvious increase in ADM levels in plasma [24][25][26][27][28]. These findings suggest that ADM may have a critical role in OH rats by decreasing BP, and alleviating inflammation and oxidative stress in cardiac tissue to improve OH-related cardiomyopathy.…”

Section: Introductionmentioning

confidence: 94%

Adrenomedullin Improves Cardiac Remodeling and Function in Obese Rats with Hypertension

Pei

Wang

et al. 2022

Pharmaceuticals

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This study aimed to determine whether adrenomedullin (ADM, 7.2 μg/kg/day, ip), an important endogenous active peptide, has a protective role in cardiac remodeling and function in obesity-related hypertension (OH) rats. A high-fat diet (HFD) was used to induce OH for 20 weeks. H9c2 cells incubated with palmitate (PA, 200 μM) to mimic high free fatty acid in obesity were used as an in vitro model. In OH rats, ADM not only decreased body weight (BW) and blood pressure (BP) but also improved systemic inflammation and oxidative stress. Moreover, ADM still had a greater inhibitory effect on local inflammation and oxidative stress in the hearts of OH rats, and the same anti-inflammatory and antioxidant effects were also confirmed in PA-treated H9c2 cells. The ADM receptor antagonist or Akt inhibitor effectively attenuated the inhibitory effects of ADM on inflammation and oxidative stress in PA-stimulated H9c2 cells. Furthermore, ADM application effectively normalized heart function, and hematoxylin-eosin and Masson staining and collagen volume fraction results showed that ADM improved cardiac remodeling in hearts of OH rats. ADM attenuated cardiac inflammation and oxidative stress via the receptor-Akt pathway, which involves the improvement of cardiac remodeling and function in OH rats.

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Plasma adrenomedullin level in children with obesity: relationship to left ventricular function

Cited by 11 publications

References 49 publications

Adrenomedullin Attenuates Inflammation in White Adipose Tissue of Obese Rats Through Receptor‐Mediated PKA Pathway

Adrenomedullin Attenuates Inflammation in White Adipose Tissue of Obese Rats Through Receptor‐Mediated PKA Pathway

A Review of Adrenomedullin in Pediatric Patients: A Useful Biomarker

Adrenomedullin Improves Cardiac Remodeling and Function in Obese Rats with Hypertension

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