Plasma Adiponectin Levels and Five-Year Survival After First-Ever Ischemic Stroke

Efstathiou, Stamatis P.; Tsioulos, Dimitrios I.; Tsiakou, Andriani; Gratsias, Yannis E.; Pefanis, Angelos; Mountokalakis, Theodore D.

doi:10.1161/01.str.0000177874.29849.f0

Cited by 146 publications

(111 citation statements)

References 32 publications

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“…14 Conflicting results have also been published for adiponectin and stroke. Whereas adiponectin levels showed an inverse relation with stroke severity on admission and 5-year survival in a clinic-based study, 15 no association was found between adiponectin and first-time stroke using data from population-based surveys in northern Sweden. 16 Adiponectin levels are considerably higher in women than in men.…”

Section: Introductionmentioning

confidence: 75%

Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000

et al. 2006

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Background: In men, high adiponectin concentrations were related to a lower risk of myocardial infarction, whereas no association with cardiovascular events was found in women. Objective: To investigate sex differences in the associations of adiponectin with cardiovascular risk factors. Design: Cross-sectional population-based KORA Survey 2000 in Southern Germany using the same study methods for cardiovascular risk factors as the former WHO MONICA project. Participants: A total of 697 men and 657 women, aged 55-74 years. Glucose tolerance status was assessed by oral glucose tolerance tests. Results: Adiponectin (geometric mean, interquartile range; mg/ml) levels were significantly higher in women (11.1; 8.5-14.9) than in men (7.1; 5.2-9.6) (Po0.05). In univariate analyses, HDL-cholesterol and age were significantly positively correlated with adiponectin in both sexes. Negative correlations were observed with BMI, waist circumference, fasting and postchallenge glucose, insulin, HOMA-IR, HbA1c, triglycerides, uric acid and CRP (Po0.01). In sex-specific multivariate regression, age and HDL-cholesterol were independently positively, and fasting insulin and 2-h glucose were negatively related to adiponectin in both sexes. Uric acid was significantly inversely related to adiponectin in women only (sex interaction: P ¼ 0.02). Exploratory sex-specific factor analysis of adiponectin and the core components of the metabolic syndrome yielded four similar factors. Adiponectin loaded negatively on the 'lipids' factor in both sexes. Conclusion: The associations of adiponectin with cardiovascular risk factors showed a similar pattern in both sexes, except for uric acid. This small sex difference may not explain previous conflicting results on the association of adiponectin with cardiovascular events in men and women.

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Section: Introductionmentioning

confidence: 75%

Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000

et al. 2006

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“…14 Furthermore, did not predict the development of first ever stroke, 20 but was related to survival after ischaemic stroke. 41 Our current results should therefore be interpreted with caution, considering the size of the study. A further limiting factor might have been measuring the total adiponectin pool and not its subfractions.…”

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confidence: 78%

Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study

et al. 2008

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Objective: To investigate the relationships between plasma leptin and adiponectin levels and recurrent cardiovascular events (cardiovascular death, nonfatal myocardial infarction and stroke) in men with earlier acute coronary syndromes. Design, subjects and measurements: A nested case-control study examined circulating leptin and adiponectin levels in plasma obtained 4-6 years after entry into the Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) trial. Plasma was assayed from 184 men who suffered recurrent events within 4.4 years after blood collection and 184 matched controls who remained free of further events. The association between cardiovascular events and the explanatory variables was examined by conditional logistic regression analysis. Results: Relative risk (RR) increased across increasing leptin quartiles; the highest quartile compared with the lowest quartile was related to the highest risk (P for trend ¼ 0.002); the increased risk remained after adjustment for risk factors (P ¼ 0.018) or for obesity (P ¼ 0.038), but in the final model (adjusted for randomized treatment, other drugs, LIPID risk score, age and body mass index), the risk was attenuated (RR ¼ 1.61, 95% CI: 0.72-3.57, P for trend ¼ 0.34). Adiponectin did not predict cardiovascular events. Subjects randomly allocated to pravastatin had 6% lower leptin levels (P ¼ 0.04) than those allocated to placebo. Conclusion: Plasma leptin was a significant and independent predictor of recurrent cardiovascular events (cardiovascular death, nonfatal myocardial infarction and stroke) in men with earlier acute coronary syndromes.

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“…Moreover, the effect of adiponectin was supported by human cohort study in which hypoadiponectinemia apparently predicted the development of type 2 diabetes [7]. A low level of adiponectin was also associated with a higher risk for myocardial infarction and mortality after stroke [8].…”

Section: Introductionmentioning

confidence: 88%

Hypoadiponectinemia in Obesity: Association with Insulin Resistance

et al. 2012

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Obesity is risk factor for insulin resistance, diabetes, and other chronic diseases. Adiponectin, an adipose-specific protein with antiatherogenic and antiinflammatory effects, were found to be associated with obesity, type 2 diabetes, and insulin resistance. Our aim to identify possible relationships between circulating adiponectin and obesity as well as obesity related phenotypes. A total of 642, obese and non-obese individuals were included in this cross-sectional study. Hormone and glucose levels were estimated using standard protocols. The adiponectin levels showed a significant decrease with increasing quartiles of insulin resistance index. Subjects in lowest quartile of adiponectin level had a significantly higher risk than those in the highest quartile, with higher body mass index, waist circumference, blood pressure, percentage body fat, fat mass, fasting insulin, insulin resistance index, total cholesterol (p \ 0.001), low density lipoprotein-cholesterol (p = 0.001), very low density lipoprotein-cholesterol (p = 0.002), and Triglyceride (p = 0.002). The present study indicates that adiponectin is significantly associated with obesity, insulin resistance and other obesity related phenotypes.

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Plasma Adiponectin Levels and Five-Year Survival After First-Ever Ischemic Stroke

Cited by 146 publications

References 32 publications

Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000

Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000

Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study

Hypoadiponectinemia in Obesity: Association with Insulin Resistance

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