Plasma Adiponectin Concentrations in Patients with Chronic Renal Failure: Relationship with Metabolic Risk Factors and Ischemic Heart Disease

Tentolouris, Nikolaοs; Doulgerakis, D.; Moyssakis, Ioannis; Kyriaki, Despoina; Makrilakis, Konstantinos; Kosmadakis, George; Stamatiadis, D.; Katsilambros, N.; Stathakis, C

doi:10.1055/s-2004-826022

Cited by 50 publications

(40 citation statements)

References 24 publications

(53 reference statements)

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“…Tentolouris et al 43 did not find any differences in adiponectin levels between the CRF and HD patient groups. However, Malyszko et al 39 and Adamczak et al 44 reported increased levels of adiponectin in HD patients compared with those of the CRF or KT patient groups and KTR or control groups, respectively.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

2016

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Background: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in patients with chronic kidney disease (CKD) including kidney transplant recipients (KTR). Secondary lipid metabolism disorders, endothelial dysfunction, and inflammation enhance the risk of CVD development in these patients. The aim of the present study was to investigate the lipid profile, adiponectin, leptin, nitric oxide (NO), and high sensitivity C-reactive protein (hs-CRP) levels in KTR and to compare these parameters with those of the patients with chronic renal failure (CRF), hemodialysis (HD) patients, and healthy controls. Methods: Serum adiponectin and leptin levels were measured by radioimmunoassay; hs-CRP was determined immunoturbidimetrically. Determination of NO was based on the Griess reaction. Results: Compared with the control group, serum NO and adiponectin levels were significantly higher in the KTR, CRF, and HD groups; hs-CRP levels were significantly higher in the KTR and HD groups; leptin levels were significantly higher in the KTR. In addition, serum NO level was significantly higher in the KTR compared to CRF cases. Adiponectin correlated positively with high density lipoprotein-cholesterol in the control and patient groups. A positive correlation was observed between hs-CRP and NO in the KTR and the patients with CRF. Serum adiponectin levels were inversely correlated with hs-CRP and leptin in the HD group. Conclusion: KTR suffer from inflammation and accompanying changes in levels of adipocytokines and NO which contribute to the increased risk of CVD in these patients.

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Section: Discussionmentioning

confidence: 99%

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

2016

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“…Most [12][13][14][15][16][17][18], although not all [38][39][40] previous studies have reported a direct correlation between circulating adiponectin and UAE rate. This finding was somewhat 'unexpected' if insulin resistance was regarded as the common soil of both variables, and pointed to the role of confounding factors, including diabetes, kidney disease and related treatments, possibly affecting previous studies [12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Relationship between ADIPOQ gene, circulating high molecular weight adiponectin and albuminuria in individuals with normal kidney function: evidence from a family-based study

et al. 2011

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Aims/hypothesis Insulin resistance is associated with reduced serum adiponectin and increased albuminuria levels. Thus, one would anticipate an inverse relationship between circulating adiponectin and albuminuria. However, several studies have described a 'paradoxical' elevation of serum adiponectin in patients with elevated albuminuria. These findings may have been confounded by the presence of diseases and related treatments known to affect circulating adiponectin and albuminuria. We therefore studied the relationship between circulating adiponectin and albuminuria in the absence of such confounders. Methods To this purpose, the relationship between adiponectin isoforms and albumin:creatinine ratio (ACR) was investigated in a family-based sample of 634 non-diabetic untreated white individuals with normal kidney function. We also investigated whether the two variables share a common genetic background and addressed the specific role of the gene encoding adiponectin on that background by genotyping several ADIPOQ single nucleotide polymorphisms (SNPs). Results ACR was directly associated with high molecular weight (HMW) adiponectin isoform (p=0.024). The two variables shared some genetic correlation (ρ g = 0.38, p=0.04). ADIPOQ promoter SNP rs17300539 was associated with HMW adiponectin (p=4.8×10 −5 ) and ACR (p=0.0027). The genetic correlation between HMW adiponectin and ACR was no longer significant when SNP rs17300539 was added to the model, thus reinforcing the role of this SNP in determining both traits.Conclusions/interpretation Our study shows a positive, independent correlation between HWM adiponectin and ACR. ADIPOQ variability is associated with HMW adiponectin and ACR, and explains some of the common genetic background shared by these traits, thus suggesting that ADIPOQ and HMW adiponectin modulate albuminuria levels.

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“…It may also limit cardiac remodeling (10,11). Only very few relatively small studies in selected populations investigated adiponectin in relation to arterial stiffness and had inconsistent results (12)(13)(14)(15). To our knowledge, no study has investigated the potential role of adiponectin in the relationship between precisely measured fat distribution and arterial stiffness.…”

Section: Introductionmentioning

confidence: 97%

“…Because renal function may influence adiponectin levels (15) We obtained self-reported information on health status, medical history, current medication use, physical activity (min/week), alcohol intake (g/day), macronutrient intake (energy %), and current smoking (yes/no) by questionnaires.…”

Section: Additional Measurementsmentioning

confidence: 99%

Relationship of adiposity with arterial stiffness as mediated by adiponectin in older men and women: the Hoorn Study

Snijder

Flyvbjerg

Stehouwer

et al. 2009

European Journal of Endocrinology

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Objective: To investigate whether adiponectin is associated with arterial stiffness, and whether adiponectin explains the association between body composition and arterial stiffness. Design: Cross-sectional cohort study. Methods: Subjects were participants (nZ456, mean age 68.9G6.1 years; age range 60-86 years) of the third follow-up examination of the Hoorn Study. Trunk fat, leg fat, trunk lean, and leg lean mass were measured by dual-energy X-ray absorptiometry. Ultrasound was used to measure distensibility and compliance of the carotid, femoral, and brachial arteries, and carotid Young's elastic modulus (as estimates of peripheral arterial stiffness). Results: Trunk fat mass was negatively associated with (ln-transformed) adiponectin (standardized bZK0.49, P!0.001), while leg fat mass was positively associated with adiponectin (bZ0.44, P!0.001), after adjustment for each other, age, and lean mass. After adjustment for age, sex, mean arterial pressure, and estimated glomerular filtration rate, higher adiponectin was associated with decreased peripheral arterial stiffness (b of mean Z-scores of all three arteriesZ0.14, PZ0.001). However, the associations of trunk fat (bZK0.26, P!0.001) and leg fat (bZ0.16, PZ0.006) with peripheral arterial stiffness were only minimally explained by adiponectin levels. Conclusion: Trunk fat and leg fat are oppositely associated with adiponectin. Although low adiponectin was a determinant of increased peripheral arterial stiffness, it only explained a small part of the association between body fat and peripheral arterial stiffness. This indicated that factors other than adiponectin may be more important in the pathophysiological mechanisms by which abdominal obesity leads to arterial stiffness.

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Plasma Adiponectin Concentrations in Patients with Chronic Renal Failure: Relationship with Metabolic Risk Factors and Ischemic Heart Disease

Cited by 50 publications

References 24 publications

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

Relationship between ADIPOQ gene, circulating high molecular weight adiponectin and albuminuria in individuals with normal kidney function: evidence from a family-based study

Relationship of adiposity with arterial stiffness as mediated by adiponectin in older men and women: the Hoorn Study

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