Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status

Abstract

The objective of this study was to analyse the relationship between the ambulatory blood pressure (ABP) measurement and plasma adiponectin levels in a population-based cohort. Non-hypertensive, non-diabetics from the Oulu Project Elucidating Risk of Atherosclerosis cohort aged 40-60 years with ABP measurement available in 226 men and 236 women were analysed. ABP was recorded using the fully automatic SpaceLabs 90207 oscillometric unit. Plasma adiponectin concentrations were assayed using the enzyme-linked immunosorbent assay method. Without adjustment the highest plasma adiponectin tertile was associated with the lowest ABP and office BP measurements (P from 0.025 to Po0.001, respectively). Only the association of plasma adiponectin concentration with systolic ABP was independent of other conventional risk factors (age, body mass index (BMI), waist, gender, insulin sensitivity index, smoking and alcohol consumption) for hypertension (P ¼ 0.017). No association was observed between systolic dipping pattern and adiponectin level. The plasma high adiponectin concentration is independently associated with low daytime systolic ABP value. The mechanisms may include effects on endothelial function and the sympathetic nervous system.

The effect of antenatal factors and postnatal growth on serum adiponectin levels in children

“…The effects may be partially mediated by intra-hepatic fat accumulation, which also leads to decreased insulin sensitivity, or an adverse lipoprotein profile. 29,30 Like others, [31][32][33][34] we found an inverse relationship of adiponectin and systolic blood pressure. The mechanisms by which adiponectin can regulate blood pressure appear to be independent of body size, 31 and may be mediated through altered vascular reactivity.…”

Common variation in the adiponectin gene has an effect on systolic blood pressure

“…Previous studies have demonstrated that lower adiponectin levels are associated with a variety of cardiovascular risk factors including endothelial dysfunction, 7 increased carotid intima media thickness 8 and increased ambulatory blood pressure 9 (interestingly, as we observed for adiponectin genotype, the association with adiponectin levels appeared to be restricted to systolic pressure). Treatment of patients with type II diabetes with the PPAR-g agonist rosiglitazone results in a twofold increase in plasma adiponectin levels, 21 and specific adiponectin receptor agonists or adiponectin sensitizers have been suggested as potential treatments to reduce cardiometabolic risk.…”

“…[2][3][4] Adiponectin has been shown to suppress the transformation of macrophages into foam cells 5 and is detected in catheterinjured vessels but not in intact vessels. 6 Low adiponectin levels are associated with endothelial dysfunction, 7 increased carotid intima media thickness 8 and increased ambulatory systolic blood pressure (SBP) 9 whereas higher plasma levels have been associated with a lower risk of myocardial infarction. 3 A number of single-nucleotide polymorphisms (SNPs) in the ADIPOQ gene have been described.…”

Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications

“…51 Higher circulating adiponectin levels are associated with lower BP in humans. 52–54 Metabolic syndrome and hypertension are associated with low adiponectin levels. 55,56 Importantly, subjects with low adiponectin levels exhibit cardiac sympathetic overactivity.…”