Plasma adiponectin concentration is associated with the average accelerometer daily steps counts in healthy elderly females

Abstract

This study is aimed to evaluate whether circulating adiponectin concentration is associated with physical activity (PA) level in healthy older females. To date, daily PA in older adults (> or = 65 years) has primarily relied on self-report. This study used accelerometry, which objectively measured minute-by-minute movement to assess PA volume and intensity performed by elderly females. In addition, body composition, leptin and insulin resistance values were measured to assess the influence of these parameters on the possible relationship between adiponectin and PA levels in this specific age group of older women. On 49 women (mean age: 73.6 +/- 4.2 years), adiponectin, leptin, insulin resistance, body composition and 7-day PA parameters were measured. Average daily accelerometer step counts and time spent in different PA levels were obtained from 7-day PA measurement. Average daily accelerometer step-count was 7,722 +/- 3,069 steps day(-1) and the recommended 150 min weekly of at least moderate/vigorous PA in bouts of at least 10 min was achieved by 71.4% (35/49) of the participants. Correlation analysis showed that plasma adiponectin concentration (16.0 +/- 6.1 microg ml(-1) ) was related (P < 0.001) to steps per day (r = 0.438) and leptin (r = -0.443) values. Multivariate regression analysis further revealed that only steps per day and leptin were independent predictors of circulating adiponectin concentration in healthy elderly females. In conclusion, these data support the hypothesis that being physically active is associated with better adiponectin concentration and a reduced risk of having metabolic disease risk in the specific group of healthy elderly females.

Normal mitochondrial function and increased fat oxidation capacity in leg and arm muscles in obese humans

“…Although VO 2max is not higher in PO compared with C subjects, the observed higher energy expenditure implies a higher level of daily physical activity, which is known to increase plasma adiponectin levels. 47,48 Previous studies have reported adipose tissue hyperplasia in the PO state, 49 and it is possible that this may also influence the fasting basal adiponectin levels.…”

Adiponectin, Leptin and Objectively Measured Physical Activity in Adults: A Narrative Review

“…Physical activity was associated with changes in body weight or body fat which will further affect insulin sensitivity (7). Thus, increased physical activity specifically those with moderate to high intensity may increase adiponectin (8)(9)(10)(11)(12)(13)(14)(15)(16) and decrease leptin levels (8-11, 13, 17-20).…”

“…An accelerometer was used to measure physical activity in all six studies included. Plasma adiponectin and leptin were mostly analysed by using enzyme-linked immunosorbent assay (ELISA) (10, 31) and radio immune assay (RIA) (8,9,17,27) daily PA in older adults (> or = 65 years. The intra-assay coefficient of variation (CV) was in the range from 3% to 10% for adiponectin while 10% for leptin.…”

Voluntary exercise under a food restriction condition decreases blood branched-chain amino acid levels, in addition to improvement of glucose and lipid metabolism, in db mice, animal model of type 2 diabetes

“…Regarding the effect of exercise on hormone levels related to nutrient metabolism, exercise increased adiponectin and decreased leptin in blood (Table 1), leading to enhanced insulin sensitivity, as in humans [36,37]. The altered levels of blood adiponectin and leptin cannot be explained by gene expressions in WAT because exercise did not significantly influence the expression level of adiponectin and leptin in WAT (data not shown).…”