Plasma Active Renin, Angiotensin I, and Angiotensin II During Pregnancy and in Preeclampsia

Langer, B.; Grima, Michèle; Coquard, Catherine; Bader, Anne-Marie; Schlaeder, G; Imbs, Jean-Louis

doi:10.1016/s0029-7844(97)00660-1

Cited by 104 publications

(83 citation statements)

References 23 publications

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“…A suggested sequence of events is as follows: initial vasodilation and a subsequent lower blood pressure, followed by increases in PRA release and angiotensin II generation for the maintenance of blood pressure within the normal range [14]. The suppression of RAS, as evidenced by a reduced PRA and PAC, occurs in women with pregnancy-induced hypertension [11][12][13]15], as was also confirmed in the present study.…”

Section: Discussionsupporting

confidence: 85%

“…The circulating plasma volume is decreased in preeclampsia [10], and preeclampsia is thought to occur as a result of a derangement in the delicate RAS [9], although the precise mechanisms leading to the development of preeclampsia remain unknown. Reductions in the PAC and PRA occur temporally close to the clinical manifestation of preeclampsia in women with this condition [11][12][13], and an increase in the PAC-to-PRA ratio also occurs in women with preeclampsia because of the relatively smaller decrease in the PAC than in the PRA in women with this disease condition [12].…”

Section: Introductionmentioning

confidence: 96%

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Association of Antithrombin Activity with Plasma Aldosterone Concentration and Plasma Renin Activity in Pregnant Women

Yamada

Koyama

Furuta

et al. 2012

Hypertension in Pregnancy

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OBJECTIVE:To test the hypothesis that the blood antithrombin (AT) activity is correlated with the plasma aldosterone concentration (PAC), the plasma renin activity (PRA), and/or the PAC-to-PRA ratio during the late stage of pregnancy. METHODS:The AT activity, PAC, and PRA were determined within 7 days prior to delivery in 47 women, consisting of 30 normotensive and 6 hypertensive women with singleton pregnancies and 11 normotensive women with twin pregnancies. RESULTS:The median values of the 47 women were 86% of the normal activity level for the AT activity, 442 pg/ml for the PAC, 3.7 ng/ml/h for the PRA, and 108 pg/ml per ng/ml/h for the PAC-to-PRA ratio. Women with an AT activity ≤ 86% had a significantly lower PRA and a higher PAC-to-PRA ratio than women with an AT activity > 86% (3.5 ± 3.0 vs. 6.6 ± 4.7 ng/ml/h for PRA, P=0.008; 156 ± 109 vs. 97 ± 46 pg/ml per ng/h for PAC-to-PRA ratio, P= 0.021). The AT activity was significantly correlated positively with the PRA and negatively with the PAC-to-PRA ratio. CONCLUSIONS:The existence of a common pathophysiological background between a reduced AT activity and a reduced PRA during the late stage of pregnancy was suggested.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 96%

Association of Antithrombin Activity with Plasma Aldosterone Concentration and Plasma Renin Activity in Pregnant Women

Yamada

Koyama

Furuta

et al. 2012

Hypertension in Pregnancy

View full text Add to dashboard Cite

show abstract

“…In normal singleton pregnancies, the serum and urinary aldosterone levels are increased, reaching a maximum during the third trimester [2,10]. The plasma renin activity (PRA) is also increased during pregnancy, reportedly reaching a maximum at different stages of pregnancy partially because of differences in assay methods [10]:…”

Section: Introductionmentioning

confidence: 99%

“…The plasma renin activity (PRA) is also increased during pregnancy, reportedly reaching a maximum at different stages of pregnancy partially because of differences in assay methods [10]:…”

Section: Introductionmentioning

confidence: 99%

Plasma Aldosterone Concentration and Plasma Renin Activity Decrease during the Third Trimester in Women with Twin Pregnancies

Koyama

Yamada

Furuta

et al. 2012

Hypertension in Pregnancy

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OBJECTIVE: Changes in the plasma aldosterone concentration (PAC) and the plasma renin activity (PRA) have not been extensively studied in women with twin pregnancies. METHODS:The PAC and PRA levels were determined during the second and third trimesters and on postpartum day 3 in 14 normotensive women with twin pregnancies and 80 normotensive and 7 preeclamptic women with singleton pregnancies. RESULTS:In women with twin pregnancies, elevated PAC and PRA levels (598 ± 248 pg/mL and 10.0 ± 4.7 ng/mL/hour, respectively) in the second trimester decreased significantly during the third trimester (to 396 ± 210 pg/mL and 3.5 ± 2.9 ng/mL/hour, respectively), while the corresponding PAC increased significantly from 421 ± 207 pg/mL to 667 ± 371 pg/mL and the PRA did not change significantly (from 7.3 ± 3.4 ng/mL/hour to 6.9 ± 4.2 ng/mL/hour) in women with normal singleton pregnancies.These changes in the PAC and PRA levels in women with twin pregnancies resembled those in hypertensive women with singleton pregnancies. CONCLUSIONS:In women with twin pregnancies, both the PAC and PRA levels were significantly enhanced during the second trimester, while those in the third trimester were significantly reduced compared with those in women with normal singleton pregnancies.

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“…The Renin-Angiotensin System (RAS) is a hormone signaling cascade that regulates blood pressure and systemic electrolyte and fluid balance. Regulation of the RAS in preeclampisa has been researched, different with uncomplicated pregnancy, in which most circulating RAS components increase, preeclamptic women have lower circulating levels of RAS components [4]. Whether the same case of the level of RAS components in preeclampsia happens in gestational hypertension patients, little study has been set.…”

Section: Introductionmentioning

confidence: 99%

Regulation of renin-angiotensin system in gestational hypertension

Jin¹,

Zhang²,

Zhu³

et al. 2017

Obstet Gynecol Rep

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Background: Hypertension is common disease amongst women with pregnancy. It is associated with significant maternal, fetal and infant morbidity. Current research on the mechanism of the hypertensive disorders is limited. The Renin-Angiotensin System (RAS) is a hormone signaling cascade that regulates blood pressure and systemic electrolyte and fluid balance. Our study was designed to focus on the mechanism of gestational hypertension before preeclampsia occurred, exploring the change in both circulating RAS and local RAS.

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Plasma Active Renin, Angiotensin I, and Angiotensin II During Pregnancy and in Preeclampsia

Cited by 104 publications

References 23 publications

Association of Antithrombin Activity with Plasma Aldosterone Concentration and Plasma Renin Activity in Pregnant Women

Association of Antithrombin Activity with Plasma Aldosterone Concentration and Plasma Renin Activity in Pregnant Women

Plasma Aldosterone Concentration and Plasma Renin Activity Decrease during the Third Trimester in Women with Twin Pregnancies

Regulation of renin-angiotensin system in gestational hypertension

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