Plasma Activated Oil: Fast Production, Reactivity, Stability, and Wound Healing Application

Abstract

The “third-generation” cooking oil based drug, named plasma activated oil (PAO), is produced in cheap olive oil by a single-step, room temperature, energy-efficient, and environment-friendly dry plasma-enabled process. The streamer-surface discharge generates abundant energetic species, atomic oxygen at the plasma–oil interface. The otherwise challenging dissociation of CC double bonds by energetic species and oxidation by the plasma generated atomic oxygen is the key mechanism to produce the H2O2 active species and carboxylic acid in the PAO. It is shown that the peroxide value and acid value of PAO are 7.5 times and 57% higher than those of the traditional ozonated oil, respectively. Different from plasma activated water whose shelf life was less than 1 week, PAO could be stored at room temperature for at least 3 months, and a shelf life of up to 1 year is expected. We further reveal that the PAO can not only sterilize the wound, but also promote more release of growth factor such as VEGF and CD34; therefore, the wound healing of PAO is 28.5% faster than that of the control group.

Dyeing Para-Aramid Textiles Pretreated with Soybean Oil and Nonthermal Plasma Using Cationic Dye

“…In a study on the tribological properties of air plasma polymerized soybean oil, Zhao et al [ 33 ] concluded that the free radicals in the long-chain oil molecules, which were formed by the opening of the double bonds under the plasma conditions, could capture the reactive O and N species to produce and incorporate carbonyl, organic amine and nitrogen heterocyclic groups into the polymerized oil network. Moreover, depending on the duration of the NTP treatment in the dyeing procedure, the soybean oil might undergo processes such as complex oxidations, decomposition or fragmentation, to form reactive intermediate sites (e.g., ethers, furans, peroxides, carboxylic acids or 1,2,4-trioxolane [ 38 , 39 ]) on the para-aramid fiber fabrics that serve as catalysts or ligands to bind dye molecules.…”

Soybean Oil and Nonthermal Plasma Pretreatment to Dye Para‐Aramid Woven Fabrics with Disperse Dye Using a Glycerol‐Based Dye Bath

“…Crosslinking/polymerization by the action of RONS and other active plasma species possibly occur because hydrogenation, nitration, and epoxidation Change of K/S by subtracting K/S after first detergent wash from that after second detergent wash. reactions were observed along with polymerization under atmospheric NTP (Ximena, 2020). Moreover, depending on the time length of NTP treatment, soybean oil might undergo complex oxidations, decompositions, and fragmentations, forming intermediate chemicals such as ethers, furans, peroxides, carboxylic acids, and 1,2,4-trioxolane (van Durme et al, 2014;Zou et al, 2019) that might serve as catalysts or ligands to fix dye molecules on the para-aramids.…”

Plasma-Activated Saline Promotes Antibiotic Treatment of Systemic Methicillin-Resistant Staphylococcus aureus Infection

“…In the murine model, the effect of PAS was complicated due to the complex biological systems. At present, studies on the application of plasma-activated liquid on infectious disease are focused on the treatment of wound infections, however, the injection of plasma-activated liquid for the treatment of internal infection has not been reported [ 60 , 61 ]. Several previous studies have demonstrated that plasma-activated medium produced by the dielectric barrier discharge device with the working gas of oxygen and air could induce the death of immunogenic cells by activating the innate immune system [ 32 , 62 , 63 ].…”