Plasma 6β‐hydroxycortisol to cortisol ratio as a less invasive cytochrome P450 3A phenotyping method
Ryohei Hirano,
Akitomo Yokokawa,
Tomomi Furihata
et al.
Abstract:AimA less invasive evaluation method of cytochrome P450 3A (CYP3A) activity provides an important tool for personalized medicine. We aimed to clarify the usefulness of the plasma 6β‐hydroxycortisol to cortisol concentration (6β‐OHF/F) ratio as a minimally invasive CYP3A phenotyping method.MethodsPlasma 6β‐OHF and cortisol concentrations were measured via liquid chromatography/tandem mass spectrometry. The plasma 6β‐OHF/F ratio was compared with 6β‐hydroxylation clearance of endogenous cortisol (CLm(6β); which … Show more
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