Plasma 6-keto prostaglandin F1α and thromboxane B2 in sick preterm neonates

Hutchison, Alastair A.; Ogletree, Martin L.; Palme, Charlotte; Leheup, Bruno; Barrett, Jeffrey M.; Fleischer, Arthur C.; Stahlman, Mildred T.; Brigham, Kenneth L.

doi:10.1016/0262-1746(85)90017-4

Cited by 18 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experiments have proven that all of the strong vasoconstrictors are related to a high-hemorrhage rate and neuronal damage [20][21][22]. In the study, we found that there was a significant difference in TXB2, 6-K-PGF1ɑ, and ET between the GTRH group and the STRH group within 3-7 d after the operation.…”

Section: Discussionmentioning

confidence: 64%

Gross-total hematoma removal of hypertensive basal ganglia hemorrhages: A long-term follow-up

Zuo

Cheng

Gao

et al. 2009

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 64%

Gross-total hematoma removal of hypertensive basal ganglia hemorrhages: A long-term follow-up

Zuo

Cheng

Gao

et al. 2009

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…In the latter study, levels of 6-keto-PGF 1 ␣ were elevated in infants with infection, which was associated with an increased rate of late PDA and unresponsiveness to indomethacin ( fi g. 3 ). Elevated levels of PG have been associated with ductal patency in preterm infants [58][59][60] and in response to bacterial infections [61][62][63] .…”

Section: Pda and Bronchopulmonary Dysplasiamentioning

confidence: 99%

Patent Ductus Arteriosus and Respiratory Outcome in Premature Infants

2005

View full text Add to dashboard Cite

A persistent ductus arteriosus is a common event in preterm infants. The systemic-to-pulmonary shunting that occurs as the pulmonary vascular resistance decreases after birth can have significant cardiovascular and respiratory consequences. Acute pulmonary effects include pulmonary edema and hemorrhage, worsened lung mechanics and deterioration in gas exchange with hypoxemia and hypercapnia. The increased pulmonary blood flow can also produce damage to the capillary endothelium and trigger an inflammatory cascade. This, plus the need for longer and more aggressive mechanical ventilation, can explain the association between patent ductus arteriosus and an increased risk for bronchopulmonary dysplasia in extremely premature infants.

show abstract

“…Prostacyclin is a vasodilatory prostaglandin that is present in high concentrations in the fetal ductus5 and the preterm transitional circulation 4. Prostacyclin is also likely to have a role in cerebral blood flow control 6.…”

mentioning

confidence: 99%

Prostacyclin concentrations and transitional circulation in preterm infants requiring mechanical ventilation

Kluckow

Evans²,

Leslie³

et al. 1999

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

Results-The mean 6KPGF 1 concentrations were higher than adult concentrations at 5 (515 pg/ml) and 24 (255 pg/ml) hours. There was no association with gestational age. Raised 6KPGF 1 concentrations were related to increased need for mechanical ventilation and severity of respiratory disease. At 5 hours, increased 6KPGF 1 concentrations were associated with larger PDA and at 24 hours with larger PDA and higher left ventricular output. Infants with higher 6KPGF 1 concentrations were more likely to develop clinically significant PDA. There was no association between early measurements of 6KPGF 1 and IVH. Conclusions-Early postnatal prostacyclin concentrations are markedly raised in preterm infants, particularly in those with more severe lung disease. Raised 6KPGF 1 concentrations were associated with an increased ductal diameter and subsequent PDA, but not IVH. (Arch Dis Child Fetal Neonatal Ed 1999;80:F34-F37)

show abstract

Plasma 6-keto prostaglandin F1α and thromboxane B2 in sick preterm neonates

Cited by 18 publications

References 19 publications

Gross-total hematoma removal of hypertensive basal ganglia hemorrhages: A long-term follow-up

Gross-total hematoma removal of hypertensive basal ganglia hemorrhages: A long-term follow-up

Patent Ductus Arteriosus and Respiratory Outcome in Premature Infants

Prostacyclin concentrations and transitional circulation in preterm infants requiring mechanical ventilation

Contact Info

Product

Resources

About