Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years

Chen, Mao; Li, Fu Rong; Yin, Zhaoxue; Lv, Yue; Luo, Jie; Yuan, Jingya; Mhungu, Florence; Wang, Jiao Nan; Shi, Wan Ying; Zhou, J H; Chen, Guo Chong; Gao, Xiang; Kraus, Virginia B.; Wu, Xian; Shi, Xiao Ming

doi:10.1093/jn/nxz041

Cited by 6 publications

(4 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A Mendelian randomization study reported that variations of SNPs that reduce serum 25(OH)D concentration accounted for a 20% increase in all-cause mortality rate per each 8 ng/mL decrease in serum 25(OH)D [118]. A prospective study of Chinese adults aged >80 years (median age, 93 years) with mean baseline 25(OH)D of 14 ng/mL followed up for 5466 person-years reported that participants with the highest 25(OH)D concentrations had a 39% reduced mortality rate [119]. In support of those data, a 20-year follow-up study in Sweden reported that sun avoidance was associated with a reduced life expectancy of 0.6 to 2.1 years compared with the highest sun exposure [120].…”

Section: Resultsmentioning

confidence: 99%

A Review of the Potential Benefits of Increasing Vitamin D Status in Mongolian Adults through Food Fortification and Vitamin D Supplementation

Grant

Boucher

2019

Nutrients

View full text Add to dashboard Cite

Serum 25-hydroxyvitamin D (25(OH)D) concentrations are low in Mongolia, averaging 22 ng/mL in summer and only 8 ng/mL in winter. Mongolians have high incidence and/or prevalence of several diseases linked to low 25(OH)D concentrations, including ischemic heart disease, malignant neoplasms, cirrhosis of the liver, ischemic stroke, lower respiratory tract infections, preterm birth complications, and diabetes mellitus. Fortifying regularly consumed foods such as flour, milk, and edible oils with vitamin D3 could raise 25(OH)D concentrations by about 10 ng/mL. However, to achieve 25(OH)D concentrations of 30–40 ng/mL in adults, vitamin D intakes of 1000 to 4000 IU/day would be required, making personal supplement use necessary. On the basis of prospective observational studies and clinical trials of disease incidence or known mortality rates and adverse pregnancy and birth outcomes, raising mean serum 25(OH)D concentrations to 40 ng/mL would likely reduce incidence and mortality rates for those and other diseases, reduce the rate of adverse pregnancy and birth outcomes, and increase mean life expectancy by one year or more.

show abstract

Section: Resultsmentioning

confidence: 99%

A Review of the Potential Benefits of Increasing Vitamin D Status in Mongolian Adults through Food Fortification and Vitamin D Supplementation

Grant

Boucher

2019

Nutrients

View full text Add to dashboard Cite

show abstract

“…The association of 25(OH)D with all-cause mortality has been extensively examined in community-based individuals aged > 80 years. Several studies have found a significant association (HR 1.56–2.02) [ 10 , 11 , 12 , 13 ], while others have reported a negative association [ 14 , 15 , 16 , 17 ]. However, to date, the association between 25(OH)D and all-cause mortality has not been investigated in centenarians.…”

Section: Discussionmentioning

confidence: 99%

“…Older adults frequently have serum 25(OH)D insufficiency [ 9 ]. The association between 25(OH)D and all-cause mortality in community-based individuals aged > 80 years remains uncertain, with several studies finding significant associations [ 10 , 11 , 12 , 13 ] and others reporting negative results [ 14 , 15 , 16 , 17 ]. The association between 25(OH)D and all-cause mortality has not been investigated in centenarians.…”

Section: Introductionmentioning

confidence: 99%

Associations of Serum 25(OH)D, PTH, and β-CTX Levels with All-Cause Mortality in Chinese Community-Dwelling Centenarians

Wang

Cheng

et al. 2022

Nutrients

View full text Add to dashboard Cite

This longitudinal cohort study explored the associations of 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), and β-C-terminal telopeptide of type 1 collagen (β-CTX) levels with all-cause mortality in centenarians. The study included 952 centenarians (81.4% female). During a median follow-up of 32 months, 752 (78.9%) centenarians died. The estimated 1-year, 3-year, and 5-year survival rates were 80.0%, 45.7%, and 23.6%, respectively. The association of mortality with 25(OH)D was linear, whereas the associations with PTH and β-CTX were J-shaped, with a lower risk below the median levels. Compared with 25(OH)D of ≥30 ng/mL, 25(OH)D < 30 ng/mL was associated with increased mortality (HR 1.52, 95% CI 1.24–1.86, p < 0.001). Compared with PTH of ≤65 pg/mL, PTH > 65 pg/mL was associated with increased mortality (HR 1.30, 95% CI 1.08–1.56, p = 0.005). Compared with β-CTX of <0.55 ng/mL, β-CTX ≥ 0.55 ng/mL was associated with increased mortality (HR 1.30, 95% CI 1.10–1.54, p = 0.002). A higher β-CTX level (even in the clinical reference range of 0.55–1.01 ng/mL) was associated with increased mortality (HR 1.23, 95% CI 1.04–1.47, p = 0.018). Centenarians with 25(OH)D < 30 ng/mL, PTH > 65 pg/mL, and β-CTX ≥ 0.55 ng/mL had a 2.77-fold (95% CI 1.99–3.85, p < 0.001) increased risk of mortality when compared with those with 25(OH)D of >30 ng/mL, PTH < 65 pg/mL, and β-CTX < 0.55 ng/mL. Lower serum 25(OH)D and higher PTH and β-CTX were independently correlated with increased all-cause mortality in Chinese community-dwelling centenarians.

show abstract

“…A similar analysis has been reported for the Chinese Longitudial Health and Longevity Study (CLHLS). In that study, Mao et al looked at plasma 25(OH)D levels in 2185 Chinese adults older than 79 years (mean 93 yrs) (32). There, all-cause mortality decreased progressively with rising plasma 25(OH)D, with the lowest mortality in those with 25(OH)D at or higher than 75 nmol/l (30 ng/ml).…”

Section: Mortalitymentioning

confidence: 99%

Critique of Public Health Guidance for Vitamin D and Sun Exposure in the Context of Cancer and COVID-19

Vieth

2022

Anticancer Res

View full text Add to dashboard Cite

Official public health pronouncements about sun exposure and vitamin D can be summarized as follows: First, there is no such thing as a safe tan. Therefore, avoid exposing the skin to sunshine. Second, in the absence of sunshine, a daily intake of 800 IU/day (20 mcg/d) vitamin D or less is sufficient for the health needs of almost all members of the population. However, exposure of the skin to sunlight induces multiple mechanisms that lower blood pressure, while also initiating production of vitamin D, which is needed to produce a hormone that regulates multiple systems including the cellular biology that affects cancer mortality. Disease-prevention relationships point to a beneficial threshold for serum D; the index of vitamin D nutrition] that is at least 75 nmol/l (30 ng/ml). To ensure the threshold for all adults, an average per-day minimum total input of vitamin D3 from sunshine/UVB exposure, and/or from food (natural food like fish or fortified food like milk), and/or vitamin supplementation of at least 4,000 IU/d (100 mcg/d) is required. Strong, although not Level-1, evidence indicates that the maintenance of that threshold will lower mortality overall, lower mortality from cancer, and lower the risk of certain other diseases such as respiratory infection and COVID-19.

show abstract

Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years

Cited by 6 publications

References 56 publications

A Review of the Potential Benefits of Increasing Vitamin D Status in Mongolian Adults through Food Fortification and Vitamin D Supplementation

A Review of the Potential Benefits of Increasing Vitamin D Status in Mongolian Adults through Food Fortification and Vitamin D Supplementation

Associations of Serum 25(OH)D, PTH, and β-CTX Levels with All-Cause Mortality in Chinese Community-Dwelling Centenarians

Critique of Public Health Guidance for Vitamin D and Sun Exposure in the Context of Cancer and COVID-19

Contact Info

Product

Resources

About