Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial

Huang, Mengna; Kelly, Rachel S.; Kachroo, Priyadarshini; Chu, Su H.; Lee-Sarwar, Kathleen; Chawes, Bo; Bisgaard, Hans; Litonjua, Augusto A.; Weiss, Scott T.; Lasky‐Su, Jessica

doi:10.3390/metabo10040151

Cited by 6 publications

(5 citation statements)

References 54 publications

(85 reference statements)

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“…Third, studies have shown that plasma VD is also related to the content of unsaturated fatty acids in blood, which is a possible regulatory pathway. It may also be the reason for poor outcomes for single use of VD to control inflammation in some people [57]. Taken together, it is not very clear how VD affects respiratory system.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis

Wang

Chen

et al. 2022

J Glob Health

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BackgroundThe role of vitamin D (VD) in the management of chronic obstructive pulmonary disease (COPD) and asthma remains largely undetermined. In the present meta-analysis, we aimed to comprehensively investigate the efficacy of VD in the treatment of COPD and asthma according to the latest update. MethodsThe PubMed, Embase, and Cochrane Library databases were searched from their inception to June 2, 2022. Randomized controlled trials (RCTs) comparing the efficacy of VD with placebo against COPD or asthma were included.Results A total of 11 RCTs consisting of 1183 COPD patients and 19 RCTs consisting of 2025 asthmatic patients were finally included. As for pulmonary function, FEV1/FVC was not changed significantly, while FEV1% was improved in the VD group. In the asthma subgroup, FEV1% was not changed significantly, while FEV1/FVC was improved in the VD group. For the questionnaire and rating scale, the mMRC (modified Medical Research Council) dyspnoea scale score for COPD and ACT (Asthma Control Test) score for asthma were not significantly changed, while the SGRQ (St. George's Respiratory Questionnaire) score for COPD was improved in the VD group. For inflammation indicators, IL-6 and IL-10 were statistically equivalent between the VD and placebo groups, while IgE, IL-5, and IL-10 (baseline VD deficiency subgroup) were improved in the VD group. The exacerbation, length of hospital stays, and mortality were statistically equivalent between the two groups.Conclusions VD supplementation improved the indicators of asthma and COPD, especially in pulmonary function, SGRQ scores, IL-5, and IgE.Registration The protocol could be found at PROSPERO with the registration number of CRD42020218058. Chronic obstructive pulmonary disease (COPD) has the highest mortality rate among chronic respiratory diseases [1]. COPD patients often show incomplete reversibility of airflow obstruction caused by emphysema and chronic bronchitis. It can eventually develop into severe diseases, such as pulmonary heart disease and respiratory failure. Currently, there is no good way to prevent development of the disease. Similarly, asthma is another common chronic inflammatory disease that can start at a young age. Like COPD, asthma can also develop into chronic airway limitation because of uncontrolled inflammation [2]. Because inflammation is crucial in pathogenesis of asthma, inflammation control is primary goal of asthma control [3]. Drug therapy includes bronchodilators, glucocorticoids and some-PAPERS

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Section: Discussionmentioning

confidence: 99%

Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis

Wang

Chen

et al. 2022

J Glob Health

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“…We also examined whether there were interactions with child sex by including interaction terms in the logistic regression models. To account for multiple comparisons while taking into consideration the high correlation between metabolites that exist within interconnected pathways, we applied the effective number of independent test (ENT) approach [ 38 , 39 ], exploring a threshold of ENT90% (accounting for 90% of the total variance in metabolites; corresponding p -value thresholds were 3.07 × 10 −4 at baseline and 3.05 × 10 −4 at third trimester). All analyses are conducted in R version 3.6.3 [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

Maternal Metabolome in Pregnancy and Childhood Asthma or Recurrent Wheeze in the Vitamin D Antenatal Asthma Reduction Trial

et al. 2021

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The in utero environment during pregnancy has important implications for the developing health of the child. We aim to examine the potential impact of maternal metabolome at two different timepoints in pregnancy on offspring respiratory health in early life. In 685 mother-child pairs from the Vitamin D Antenatal Asthma Reduction Trial, we assessed the prospective associations between maternal metabolites at both baseline (10–18 weeks gestation) and third trimester (32–38 weeks gestation) and the risk of child asthma or recurrent wheeze by age three using logistic regression models accounting for confounding factors. Subgroup analyses were performed by child sex. Among 632 metabolites, 19 (3.0%) and 62 (9.8%) from baseline and third trimester, respectively, were associated with the outcome (p-value < 0.05). Coffee-related metabolites in the maternal metabolome appeared to be of particular importance. Caffeine, theophylline, trigonelline, quinate, and 3-hydroxypyridine sulfate were inversely associated with asthma risk at a minimum of one timepoint. Additional observations also highlight the roles of steroid and sphingolipid metabolites. Overall, there was a stronger relationship between the metabolome in later pregnancy and offspring asthma risk. Our results suggest that alterations in prenatal metabolites may act as drivers of the development of offspring asthma.

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“…Two SCFA concentrations were higher in the insufficient participants compared to the sufficient participants, and eleven glycerophospholipid concentrations were lower in insufficient participants compared to sufficient participants. Previous studies examined associations between 25(OH)D concentrations and metabolites in diverse cohorts, and also reported associations with lipid metabolites [ 14 , 15 , 16 , 17 ]. While there is evidence that vitamin D plays a role in lipid metabolism (for example, through its role as an inhibitor of sterol regulatory element-binding protein (SREBP) activation), very few studies have reported data from human studies [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Metabolomics offers potential here and might help to characterise the impact of vitamin D on metabolic health, similarly to the application in metabolic healthy obese cohorts described earlier [ 8 ]. To date, very few published studies have examined metabolomic profiles associated with vitamin D status [ 14 , 15 , 16 , 17 ], and the heterogeneity between studies combined with relatively small sample sizes make it difficult to consolidate key findings. Other studies have reported metabolomic profiles following vitamin D interventions [ 7 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Vitamin D Status and Supplementation on Metabolomic Profiles of Older Adults

McCourt

O’Sullivan

2023

Metabolites

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Metabolomics can identify metabolite patterns associated with different nutrition phenotypes and determine changes in metabolism in response to nutrition interventions. Vitamin D insufficiency is associated with increased metabolic disease risk; however, the role of vitamin D in metabolic health is not fully understood. This randomised, placebo-controlled trial (RCT) examined the influence of vitamin D status and the effect of vitamin D supplementation on metabolomic profiles in older adults. Healthy adults aged 50+ were randomly assigned to consume 20 µg vitamin D3 or a placebo daily for 4 weeks. Serum samples were collected at baseline and post-intervention for 25(OH)D and metabolomics analysis via liquid chromatography tandem mass spectrometry (LC-MS/MS). Pearson’s correlation examined relationships between 25(OH)D and metabolite concentrations. GLM ANCOVA compared metabolite concentrations between vitamin D-insufficient (<50 nmol/L) and -sufficient (>50 nmol/L) participants. The repeated-measures general linear model of covariance (RM GLM ANCOVA) examined changes in metabolites over time. Out of 132 metabolites, 2 short chain fatty acid concentrations were higher in the insufficient participants compared to sufficient participants, and 11 glycerophospholipid concentrations were lower in insufficient participants compared to sufficient participants at baseline. Three acylcarnitine concentrations decreased with vitamin D supplementation in vitamin D-insufficient participants. Our findings suggest that vitamin D status influences lipid metabolism in healthy older adults and supports the use of metabolomics in vitamin D research.

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Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial

Cited by 6 publications

References 54 publications

Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis

Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis

Maternal Metabolome in Pregnancy and Childhood Asthma or Recurrent Wheeze in the Vitamin D Antenatal Asthma Reduction Trial

Influence of Vitamin D Status and Supplementation on Metabolomic Profiles of Older Adults

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