Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort

Budhathoki, Sanjeev; Hidaka, Akihisa; Yamaji, Taiki; Sawada, Norie; Tanaka‐Mizuno, Sachiko; Kuchiba, Aya; Charvat, Hadrien; Goto, Atsushi; Kojima, Satoshi; Sudo, Natsuki; Shimazu, Taichi; Sasazuki, Shizuka; Inoue, Manami; Tsugane, Shoichiro; Iwasaki, Motoki

doi:10.1136/bmj.k671

Cited by 62 publications

(77 citation statements)

References 55 publications

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“…Similar to the trend observed in other Asian countries, the prevalence of vitamin D insufficiency or deficiency was much higher in adolescent girls and young adult women than other age groups, even the elderly [5,7]. Epidemiologic studies have shown that vitamin D insufficiency or deficiency is closely associated with chronic diseases, such as tumors, cardiovascular diseases, and diabetes [8][9][10][11][12][13]. Indeed, vitamin D is fat soluble, meaning that it can be stored in body fat (BF) tissues, and excessive BF can reduce 25(OH)D levels in the body, especially in obese individuals.…”

Section: Introductionsupporting

confidence: 68%

Obesity and Vitamin D Insufficiency among Adolescent Girls and Young Adult Women from Korea

2019

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Although there is evidence of the biological mechanisms by which obesity may induce vitamin D insufficiency or deficiency, limited epidemiological studies have been conducted, especially among Asian adolescent girls and young adult women who are at a high risk of vitamin D deficiency. This study aimed to examine the cross-sectional association between obesity and vitamin D insufficiency among adolescent girls and young adult women in Korea. We used data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2014, and 3623 girls and young adult women aged 12-29 years were included. Demographic and lifestyle data were collected using a self-administered questionnaire from the health interview survey. Serum 25-hydroxyvitamin D (25(OH)D) level, body mass index (BMI), and body fat percentage (BF%) were measured during health examinations. Multivariable logistic regression was used considering the complex, multistage probability sample design of KNHANES. In the multivariable-adjusted analyses, obese girls and women, defined by BMI, were more likely to have a higher prevalence of vitamin D insufficiency (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.03-2.17). This association was also evident for BF%. Participants with ≥30% BF% had a significantly higher prevalence of vitamin D insufficiency (OR: 1.52, 95% CI: 1.07-2.16). Obesity may worsen vitamin D insufficiency among adolescents and young women because of the fat-soluble characteristics of vitamin D and related health behaviors, such as a lack of outdoor activity. Further large-scale prospective cohort studies or randomized controlled trials are warranted to confirm this causality.

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Section: Introductionsupporting

confidence: 68%

Obesity and Vitamin D Insufficiency among Adolescent Girls and Young Adult Women from Korea

2019

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“…(5) Observational epidemiological studies have found an inverse association of vitamin D status with risk of total cancer incidence and mortality. (6)(7)(8) However, a recent meta-analysis of randomized controlled trials (RCTs) has demonstrated a divergent effect of vitamin D supplementation, which reduces total cancer mortality but does not lower total cancer incidence in the general population, supporting a broad benefit of vitamin D in cancer prognosis. (9) Consistent with this hypothesis, observational cohort studies have shown improved survival in cancer patients with higher circulating vitamin D concentrations, measured before or shortly after diagnosis of cancer.…”

mentioning

confidence: 99%

Serum Bioavailable, Rather Than Total, 25‐hydroxyvitamin D Levels Are Associated With Hepatocellular Carcinoma Survival

Fang

Long²,

Zhang

et al. 2020

Hepatology

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BaCKgRoUND aND aIMS:Free and bioavailable 25-hydroxyvitamin D (25OHD) are emerging measurements of vitamin D status. It remains unclear whether circulating free or bioavailable 25OHD are relevant to hepatocellular carcinoma (HCC) prognosis. Our aim was to test the hypothesis that bioavailable 25OHD may be a better serum biomarker of vitamin D status than total 25OHD on the association with HCC survival. appRoaCH aND ReSUltS: We included 1,031 newly diagnosed, previously untreated patients with HCC from the Guangdong Liver Cancer Cohort enrolled between September 2013 and April 2017. Serum total 25OHD levels were measured using an electrochemiluminescence immunoassay. Serum-free 25OHD levels were measured using a two-step enzyme-linked immunosorbent assay. Bioavailable 25OHD levels were calculated from measured free 25OHD and albumin using a previously validated equation. Primary outcomes were liver cancer-specific (LCSS) and overall survival (OS). Cox proportional hazards models were performed to calculate the multivariable hazard ratios (HRs) and 95% confidence intervals (CIs). During a median follow-up of 726 days, 430 patients had deceased, including 393 deaths from HCC. In multivariable analyses, higher bioavailable 25OHD levels were significantly associated with better survival, independent of nonclinical and clinical prognostic factors including serum C-reactive protein, Barcelona Clinic Liver Cancer stage, and cancer treatment. The multivariable-adjusted HRs in the highest versus lowest quartile of bioavailable 25OHD levels were 0.69 (95% CI: 0.51, 0.93; P for trend = 0.014) for LCSS and 0.71 (95% CI: 0.53, 0.94; P for trend = 0.013) for OS. In contrast, neither total nor free 25OHD levels were associated with LCSS or OS. CoNClUSIoNS:Higher bioavailable, rather than total, 25OHD levels were independently associated with improved survival in a population-based HCC cohort, suggesting a potential utility of bioavailable 25OHD in HCC prognosis. (Hepatology 2020;0:1-14).

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“…Vitamin D is a hormone that regulates the calcium phosphate metabolism and its deficiency causes osteoporosis. At the same time low levels have been associated with an increased risk for melanoma and breast, colon, liver and lung neoplasms, among others . There is controversy over the optimum serum levels of 25(OH)D 3 .…”

Section: Introductionmentioning

confidence: 99%

“…At the same time low levels have been associated with an increased risk for melanoma and breast, colon, liver and lung neoplasms, among others. [3][4][5][6][7][8][9][10] There is controversy over the optimum serum levels of 25(OH)D 3 . 11,12 In general, it has been suggested that insufficiency, deficiency and sufficiency occur at 25(OH)D 3 levels of ≤ 20 ng/mL, 21-29 ng/mL and ≥ 30 ng/mL, respectively.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in solid‐organ transplant recipients from a Spanish Mediterranean population

et al. 2019

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Summary Background Solid‐organ transplant recipients (SOTRs) are at risk of developing vitamin D deficiency, mainly caused by reduced sunlight exposure with subsequent low vitamin D synthesis in the skin. Aim To analyse whether SOTRs from a Spanish Mediterranean region were vitamin D‐deficient. Methods This was a cross‐sectional, descriptive and observational study in a transplantation‐specialized Dermatological Unit from a Mediterranean area to determine the calcidiol levels of a cohort of 78 consecutively attending patients not receiving vitamin D supplements. Serum 25(OH)D3 levels were determined and clinical characteristics were collected. Logistic regression analysis was used to analyse variables associated with dichotomized 25(OH)D3 levels (≤ or > 10 ng/mL). Results The cohort comprised 30 lung, 29 kidney and 19 liver transplant recipients. Mean calcidiol was 18 ± 9 ng/mL. Deficiency of 25(OH)D3 was present in 19% of patients, while 68% had insufficient levels and 13% had sufficient levels. Following multivariate logistic regression analysis, the season of blood sampling remained the only predictor of deficient 25(OH)D3 levels. Conclusion Despite living in a mid‐latitude country with sunny weather, our SOTR population was at high risk of developing hypovitaminosis D, especially in autumn/winter. Avoiding sun exposure is important to prevent skin cancer, but careful monitoring of vitamin D status is recommended, with supplementation if hypovitaminosis D is detected.

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Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort

Cited by 62 publications

References 55 publications

Obesity and Vitamin D Insufficiency among Adolescent Girls and Young Adult Women from Korea

Obesity and Vitamin D Insufficiency among Adolescent Girls and Young Adult Women from Korea

Serum Bioavailable, Rather Than Total, 25‐hydroxyvitamin D Levels Are Associated With Hepatocellular Carcinoma Survival

Vitamin D deficiency in solid‐organ transplant recipients from a Spanish Mediterranean population

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