Plasma 25-Hydroxyvitamin D and Mortality in Patients With Suspected Stable Angina Pectoris

Degerud, Eirik; Nygård, Ottar; Vogel, Stefan de; Hoff, Rune; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Nilsen, Dennis W; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Dierkes, Jutta

doi:10.1210/jc.2017-02328

Cited by 20 publications

(21 citation statements)

References 42 publications

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“…Metaanalyses of several studies focusing on cerebrovascular disease have revealed similar patterns (47)(48)(49). Recently, plasma 25-hydroxyvitamin D was associated with mortality in patients with suspected stable angina pectoris (50).…”

Section: Vitamin D and Cardiovascular Physiologymentioning

confidence: 87%

Vitamin D in Cardiovascular Disease

Nitsa

Toutouza

Machairas

et al. 2018

In Vivo

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Cardiovascular disease is the prevalent cause of morbidity and mortality in the world, affecting many millions of individuals every year. Atherosclerosis, a chronic inflammatory condition that involves different cell types, several cytokines and adhesion molecules, is the underlying cause of cardiovascular disease. Vitamin D is known to control skeletal patho/physiology, regulating calcium and phosphorus and bone remodeling along with other calcium-regulating hormones. However, several active metabolites of vitamin D can exert both direct action, mainly via vitamin D receptor trans-activation and indirect actions on several other tissues by an endocrine, autocrine and paracrine manners. With regard to cardiovascular disease, vitamin D deficiency has been associated with activation of the pro-inflammatory mechanism, promoting atherogenesis. There are several large-scale clinical studies, as well as meta-analyses that support this finding. However, it is still unclear whether the plasma 25-hydroxyvitamin D level can be used as a biomarker for future cardiovascular disease. Herein we review the studies reporting a causative role for vitamin D in cardiovascular disease.

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Section: Vitamin D and Cardiovascular Physiologymentioning

confidence: 87%

Vitamin D in Cardiovascular Disease

Nitsa

Toutouza

Machairas

et al. 2018

In Vivo

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“…[15] It has been implicated that in people who suffer from cardiovascular diseases, maintenance of normal serum 25(OH) vitamin D level could reduce their mortality risk as a result of the disease by 30%. [16]…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status among women aged 40 years and above in a rural area of West Bengal: A community-based study

Pan

Banerjee

Dasgupta

et al. 2018

J Family Med Prim Care

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Introduction:Vitamin D deficiency is a recognized pandemic. Even in a tropical country like India, where there is plentiful sunshine, vitamin D deficiency is widely prevalent. Adult females, particularly those above the age of 40, are mostly affected because vitamin D determines the pattern of post-menopausal bone loss and age-related osteoporosis.Methods:A community-based cross-sectional study was conducted from April–December 2017 among 194 women aged 40 years and above residing in the village of Singur, West Bengal. For this study, multistage random sampling method was used. Each respondent was interviewed using a structured schedule to collect data on sociodemographic characteristics, dietary pattern, their daily sun exposure, tobacco use, and morbidity profile. Individuals with 25OH vitamin D <30ng/ml were said to have vitamin D insufficiency (VDI). Data entry and analysis was done using SPSS version 16.0.Results:Out of 194 participants, 70.6% had VDI (Vitamin D deficient-19.6%, Vitamin D insufficient-51.0%). Mean (SD) age of the participant was 56.9 (8.9) years. Mean (SD) duration of daily sun exposure was 138.5 (59.2) minutes. 74 (38.1%) had overweight/obesity. Only 73 (37.6%) had adequate diet. Test results revealed low SES, decreasing duration of daily sun exposure, diabetes, overweight/obesity, and inadequate diet as significant predictors of VDI, explaining 39.3% of the variance with model fit.Conclusion:The study has identified factors associated with VDI among the study participants. Emphasis on promoting consumption of vitamin D rich food and with vitamin D supplements, outdoor activities to increase sun exposure, maintaining optimum body weight, and strictly adhering to diabetes control will help alleviate the problem at large.

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“…On the contrary, a large Norwegian study [4] demonstrated that plasma 25-hydroxyvitamin D concentrations were inversely associated with cardiovascular mortality and nonlinearly (U-shaped) associated with all-cause mortality A total of 895 (21.8%) deaths, including 407 (9.9%) from cardiovascular disease causes, occurred during a mean follow-up of 11.9 years.…”

Section: Studies Addressing Vitamin D Deficiency and Coronary Artery mentioning

confidence: 93%

“…The possible association between vitamin D circulating levels and coronary heart disease was addressed also in other previous recent studies [3][4][5][6][7], however, the issue is intriguing and controversial.…”

Section: Introductionmentioning

confidence: 92%