Plasma 25-Hydroxy Vitamin D Is Not Associated with Either Cognitive Function or Academic Performance in Adolescents

Rahman, Abdur; Al-Taiar, Abdullah; Shaban, Lemia; Al-Sabah, Reem; Al-Harbi, Anwar; Mojiminiyi, Olusegun A.

doi:10.3390/nu10091197

Cited by 23 publications

(17 citation statements)

References 51 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We assessed cognition and motor development using Bayley Scale (Bayley-III), which is although considered as Gold Standard of developmental measurement, predicts early cognition poorly in under-two children [51]. This finding is consistent with the reports of vitamin D that looked for its association with cognition or IQ of children or adolescents [52–54]. Recent reviews in adults also reported about the inconsistent role of vitamin D on cognition [55].…”

Section: Discussionsupporting

confidence: 66%

Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh

et al. 2019

View full text Add to dashboard Cite

The association of vitamin D with neuro-behavioral outcomes of young children is unclear, particularly of those who reside in tropical countries and are otherwise exposed to adequate sun light. To investigate this association, we analysed the existing data of poor infants, who participated in an observational, prospective-cohort (MalED) study, conducted in a slum of Dhaka-city. We assessed 265 infants aged 6–8 months for cognitive, motor, language and behavior development using Bayley-III. Information about infants’ temperament and communicative skills were provided by the mothers through a culturally modified “temperament-scale” and a “communicative-developmental inventory”. Serum concentration of vitamin D [25(OH)D] was measured in 205 infants. Around 28.3% of infants in this community had low level vitamin D, with the cut-off at <50 nmol/L. After controlling for all possible covariates, a multivariable-adjusted linear regression showed that children with vitamin D levels <50 nmol/L had significantly lower scores in two dimensions of temperament: activity (B±SE 1.64±0.78; 95%CI 0.10, 3.18; p = 0.037; effect size 0.37 SDs) and soothabilty (2.02±0.70; 0.64, 3.41; p = 0.004; 0.53 SDs), compared to children with vitamin D levels of ≥50nmol/L. These infants also scored low in word comprehensions (1.28±0.62; 0.05, 2.51; p = 0.042; 0.23 SDs) and were less active during test-procedures (0.33±0.16; 0.02, 0.64; p = 0.035; 0.27 SDs). Both the groups tested similarly in cognitive and motor scores. This study found, despite adequate sunlight-exposure, one in four infants of this slum-community are suffering from a subclinical vitamin D deficiency. Higher levels of vitamin D in these infants showed a positive association with temperament, language and behavior but not with cognitive and motor development. Our findings highlight the early-detected extra-skeletal neuro-behavioral role of vitamin D. Future studies in this area will give more insight.

show abstract

Section: Discussionsupporting

confidence: 66%

Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Our findings of no association between vitamin D status and cognitive or motor function, agree with nine previous observational studies [34][35][36][37][38][39][40][41][42]. On the contrary, a small dose-response randomized controlled trial (n = 55) of vitamin D supplementation in Canadian infants reported that a lower dose of 400 international units (IU) of vitamin D was more beneficial for gross motor development than higher doses of 800 IU or 1200 IU [16].…”

Section: Discussionsupporting

confidence: 91%

Vitamin D Status Is Not Associated with Cognitive or Motor Function in Pre-School Ugandan Children

et al. 2020

View full text Add to dashboard Cite

Vitamin D deficiency is common worldwide and young children are among the most affected groups. Animal studies suggest a key role for vitamin D in brain development. However, studies investigating the effects of vitamin D on neurobehavioural outcomes in children are inconclusive and evidence is limited in sub-Saharan Africa. We evaluated the effect of vitamin D status on cognitive and motor outcomes using prospective data from the Entebbe Mother and Baby Study birth cohort. We analysed data from 302 Ugandan children with 25-hydroxyvitamin D (25(OH)D) measurements below five years and developmental measures at five years of age. We used multivariable linear regression, adjusted for potential confounders, to estimate the effect of 25(OH)D on cognitive and motor outcomes. Of 302 children, eight (2.7%) had 25(OH)D levels <50 nmol/L, 105 (35.8%) had levels 50–75 nmol/L and 189 (62.6%) had levels >75 nmol/L. There was no evidence that earlier vitamin D status was associated with cognitive and motor outcomes in five-year-old Ugandan children. This study adds to the sparse literature and highlights the need for further longitudinal studies on vitamin D and neurobehavioural outcomes in children living in sub-Saharan Africa.

show abstract

“…Study participants. This is a cross-sectional study that was conducted in selected public middle schools from the State of Kuwait as previously described 21,22 . Study participants were adolescent in the age range of 11-14 years.…”

Section: Methodsmentioning

confidence: 99%

Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents

Hammad

Abu‐Farha

Al-Taiar

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Angiopoietin-like proteins (AnGptL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 is suggested to regulate triglyceride metabolism and is increased in obesity and diabetes. However, its role in metabolic diseases in adolescents is not wellstudied. In this study, we tested the hypothesis of a positive association between plasma ANGPTL5, and obesity, high sensitivity c-reactive protein (HscRp) and oxidized low-density lipoprotein (ox-LDL) in adolescents. Adolescents (n = 431; age 11-14 years) were randomly selected from middle schools in Kuwait. Obesity was classified by the BMI-forage based on the WHO growth charts. Plasma ANGPTL5, HsCRP, and Ox-LDL were measured using ELISA. The prevalence of overweight and obesity was 20.65% and 33.18%, respectively. Mean (SD) plasma ANGPTL5 levels were significantly higher in obese, compared with overweight and normal-weight adolescents (23.05 (8.79) vs 18.39 (7.08) ng/mL, and 18.26 (6.95) ng/ml, respectively). ANGPTL5 was positively associated with both HsCRP (ρ=0.27, p < 0.001) and Ox-LDL (ρ = 0.24, p < 0.001). In Conclusion, ANGPTL5 levels are elevated in obese adolescents and are associated with cardiovascular disease risk factors, HscRp and ox-LDL. the use of ANGPTL5 as a powerful diagnostic and prognostic tool in obesity and metabolic diseases needs to be further evaluated. Childhood obesity has emerged as a major public health problem worldwide. In Arab states in the Gulf region, extremely high prevalence of childhood obesity has been reported 1. On a sample of 13, 000 school children each year, Kuwait Nutritional Surveillance has consistently reported that more than 45% of school children aged 5-19 are either overweight or obese 2. Similarly, a cross-sectional study conducted on 635 public intermediate school children reported that one quarter of the children (25.5%) were overweight and over one third (36.5%) were classified as obese 3. Indoor lifestyle, lack of physical activity and changes in the dietary pattern have been implicated as the underlying causes of childhood obesity in the region. According to the World Health Organization (WHO), the worldwide prevalence of obesity nearly tripled between 1975 and 2016 and is expected to double in the next 25 years. This highlights the importance of dealing with this epidemic. Given the widespread prevalence of obesity and its long-term and short-term complications, one approach to the problem is to focus on the key molecular pathways involved in the development of childhood obesity. This would help identify potential biomarkers that might be used to guide preventive and therapeutic interventions.

show abstract

Plasma 25-Hydroxy Vitamin D Is Not Associated with Either Cognitive Function or Academic Performance in Adolescents

Cited by 23 publications

References 51 publications

Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh

Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh

Vitamin D Status Is Not Associated with Cognitive or Motor Function in Pre-School Ugandan Children

Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents

Contact Info

Product

Resources

About