Plasma 17α-Hydroxyprogesterone in Spironolactone-Treated Hypertensives

Tan, Siang Yong; Mulrow, Patrick J.

doi:10.1210/jcem-44-6-1200

Cited by 2 publications

(1 citation statement)

References 8 publications

(10 reference statements)

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“…There are some reports that spironolactone and its major metabolite, canrenone, may interfere with radioimmunoassay for progesterone &YoungLai et al., ), aldosterone (Sadee et al, 1975, and 1 ldeoxycorticosterone (Tan et al, 1975;Abshagen et al, 1977;Tan et al, 1977). In the present study, however, the degree of cross-reactivity of spironolactone, canrenone and potassium canrenoate with our antisera indicated that our radioimmunoassay systems were free from the interference of spironolactone administration.…”

Section: The High-dosage Groupcontrasting

confidence: 50%

Increased Serum Oestrone and Oestradiol Following Spironolactone Administration in Hypertensive Men

Miyatake

Noma

Nakao

et al. 1978

Clinical Endocrinology

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The present study was undertaken to evaluate long-term effects of spironolactone on basal serum oestrone, oestradiol, testosterone, LH and prolactin concentrations in hypertensive male patients. Serum prolactin response to TRH was also evaluated. Patients were divided into two groups: a conventional-dosage group, consisting of six males with essential hypertension who took 75 to 150 mg of spironolactone daily for 12 weeks, and a high-dosage group, consisting of two males with idiopathic hyperaldosteronism who took 300 mg of spironolactone daily for more than 40 weeks. In the conventional-dosage group, serum oestrone concentrations significantly increased (P less than 0.01) at 12 weeks, serum oestradiol concentrations gradually increased throughout the study period, however, the increments were not statistically significant (P less than 0.2). Basal serum testosterone, LH and prolactin concentrations were not significantly changed throughout the study period. Enhancement of serum prolactin response to TRH was not found in any of the patients in the conventional-dosage group. In the high-dosage group, serum oestrone maintained high levels from the beginning of this study, and serum oestradiol concentrations increased with the development of gynaecomastia. Serum testosterone, LH and prolactin concentrations did not show any definite change throughout the study period. Thus, long-term spironolactone treatment increased the serum levels of oestrone and oestradiol in hypertensive men followed by the development of gynaecomastia. The elevation in circulating oestrogens could well explain the oestrogenic side-effects of spironolactone treatment.

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Section: The High-dosage Groupcontrasting

confidence: 50%

Increased Serum Oestrone and Oestradiol Following Spironolactone Administration in Hypertensive Men

Miyatake

Noma

Nakao

et al. 1978

Clinical Endocrinology

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Long Term Spironolactone and the Adrenal Cortex in Essential Hypertension

Lewis

Gorchein

James

et al. 1980

Clinical Endocrinology

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In view of recent evidence that spironolactone may inhibit synthesis of corticosteroids by a direct effect on the adrenal cortex, adrenocortical function was studied in eight patients with essential hypertension who had been treated with spironolactone from 3 months to 14 years. Their 24 h renal excretion of adrenocorticoid metabolites and the responses of cortisol, aldosterone and 18-hydroxy-11 -deoxycorticosterone (18-OH-DOC) to an incremental infusion of tetracosactrin (1-24 ACTH) were compared with those in eight patients with recently diagnosed essential hypertension who had received no spironolactone. The spironolactone-treated group had a significantly higher excretion of aldosterone, whilst the excretion of other adrenocorticoid metabolites did not differ. The same group also required less tetracosactrin to stimulate a detectable rise of plasma cortisol and 18-OH-DOC, they had greater plasma 18-OH-DOC responses at all infusion rates and, at the lowest infusion rates, had greater aldosterone responses. These results indicate that long-term spironolactone therapy does not inhibit adrenocortical function and may have some stimulatory effects.

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Plasma 17α-Hydroxyprogesterone in Spironolactone-Treated Hypertensives

Cited by 2 publications

References 8 publications

Increased Serum Oestrone and Oestradiol Following Spironolactone Administration in Hypertensive Men

Increased Serum Oestrone and Oestradiol Following Spironolactone Administration in Hypertensive Men

Long Term Spironolactone and the Adrenal Cortex in Essential Hypertension

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