Plaque Volume of Carotid Endarterectomy Specimens Measured by 3D Ultrasound Technology

Kumar, Anirudh; Yang, Eric; Brunner, Gerd; Murray, Tyler; Virani, Salim S.; Garami, Zsolt; Ballantyne, Christie M.; Morrisett, Joel D.; Nambi, Vijay

doi:10.1016/j.jcmg.2015.10.007

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Recent ultrasound developments have allowed to investigate carotid plaque volume with high reliability and repeatability 11,12 . Carotid plaque volume was demonstrated as a superior marker compared to cIMT and to carotid plaque area for prediction of CVD 13 and cardiovascular events 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Haptoglobin 1-1 is Associated with Larger Carotid Plaque Volume Among Elderly with Type 2 Diabetes: The IDCD Study.

Botvin¹,

Haratz²,

Ravona‐Springer³

et al. 2020

Preprint

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Background and aims: The haptoglobin (Hp) genotype (Hp 1-1, 1-2, or 2-2) is associated with type 2 diabetes complications. The Hp2-2 genotype has been linked to elevated CHD risk while the 1-1 genotype has been recently related to cerebral small vessel disease. This study investigated whether Hp phenotype is associated with carotid atherosclerotic structure and function among type 2 diabetes elderly patients participating in the Israel Diabetes and Cognitive Decline (IDCD) study. Methods: IDCD participants (n=472) underwent a battery of carotid atherosclerosis ultrasound assessments with measurements of carotid intima media thickness (cIMT), distensibility, elastography, and carotid plaque volume. Ordinal regression models adjusting for demographic and cardiovascular risk factors assessed the associations of categorical measures of carotid plaque volume with Hp phenotype . Logistic regression models were used to assess the association of Hp phenotype with impaired cIMT, carotid distensibility and elastography. Results: Participants averaged 76.4±4.4 years old, 42% were female, mean HbA1c was 6.7±0.7% (50±7.7 mmol/mol). Hp phenotype distribution was 46 (10.4%) Hp 1-1, 186 (40.7%) Hp 2-1 and 209 (45.7%) Hp 2-2 carriers. Carotid plaque volume was categorized into 4 groups: including no plaque (n=128) and tertiles of plaque volume: small plaque (volume ≤122 mm3, n=110), medium plaque (volume 122-273 mm3, n=106) and large plaque (volume≥274 mm3, n=104). The prevalence of Hp 1-1 phenotype increased with greater carotid plaque volume (6.5%, 10.6%, 8.8% and 16.5% in the no, small, medium, and large plaque groups respectively; p=0.027). Compared to Hp-1 carriers, non-carriers (i.e. Hp 2-1 and Hp 2-2) had approximately 30% lower risk for large carotid plaque volume, as estimated using ordinal regression (OR: 0.713 [0.496, 1.03], 0.694 [0.484, 0.997] for Hp 2-1, Hp 2-2 respectively). No associations were found between Hp phenotype and level of carotid stenosis, cIMT, carotid distensibility and carotid elastography.Conclusion: Our findings suggest that among non-demented elderly patients with type 2 diabetes, the Haptoglobin 1-1 phenotype is associated with greater carotid atherosclerosis. These findings add evidence for the involvement of the Hp 1-1 phenotype in the pathophysiology of cerebrovascular disease.

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Section: Introductionmentioning

confidence: 99%

Haptoglobin 1-1 is Associated with Larger Carotid Plaque Volume Among Elderly with Type 2 Diabetes: The IDCD Study.

Botvin¹,

Haratz²,

Ravona‐Springer³

et al. 2020

Preprint

View full text Add to dashboard Cite

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Imaging Approaches to the Diagnosis of Vascular Diseases

Gimnich

Zil-E-Ali

Brunner

2022

Curr Atheroscler Rep

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Pathological Quantification of Carotid Artery Plaque Instability in Patients Undergoing Carotid Endarterectomy

Konishi

Funayama

Yamamoto

et al. 2018

Circ J

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Background: Unstable atherosclerotic carotid plaques cause cerebral thromboemboli and ischemic events. However, this instability has not been pathologically quantified, so we sought to quantify it in patients undergoing carotid endarterectomy (CEA). Methods and Results:Carotid plaques were collected during CEA from 67 symptomatic and 15 asymptomatic patients between May 2015 and August 2016. The specimens were stained with hematoxylin-eosin and elastica-Masson. Immunohistochemistry was performed using an endothelial-specific antibody to CD31, CD34 and PDGFRβ. The histopathological characteristics of the plaques were studied. By multiple-variable logistic regression analysis, plaque instability correlated with the presence of plaque rupture [odds ratio (OR), 9.75; P=0.013], minimum fibrous cap thickness (OR per 10 μm 0.70; P=0.025), presence of microcalcifications in the fibrous cap (OR 7.82; P=0.022) and intraplaque microvessels (OR 1.91; P=0.043). Receiver-operating characteristics analyses showed that these factors combined into a single score diagnosed symptomatic carotid plaques in patients with carotid artery stenosis with a high level of accuracy (area under the curve 0.92; 95% confidence interval 0.85-0.99 vs. asymptomatic).Conclusions: This analysis of carotid plaque instability strongly suggested that the diagnostic scoring of carotid plaque instability improves the understanding and treatment of carotid artery disease in patients undergoing CEA.

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Plaque Volume of Carotid Endarterectomy Specimens Measured by 3D Ultrasound Technology

Cited by 3 publications

References 5 publications

Haptoglobin 1-1 is Associated with Larger Carotid Plaque Volume Among Elderly with Type 2 Diabetes: The IDCD Study.

Haptoglobin 1-1 is Associated with Larger Carotid Plaque Volume Among Elderly with Type 2 Diabetes: The IDCD Study.

Imaging Approaches to the Diagnosis of Vascular Diseases

Pathological Quantification of Carotid Artery Plaque Instability in Patients Undergoing Carotid Endarterectomy

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