Plaque radiotherapy for choroidal and ciliochoroidal melanomas with limited nodular extrascleral extension

Augsburger, James J.; Schneider, Susan; Narayana, Ashwatha; Breneman, John C.; Aron, Bernard S.; Barrett, William L.; Trichopoulos, Nikolaos

doi:10.1016/s0008-4182(04)80009-7

Cited by 17 publications

(14 citation statements)

References 18 publications

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“…The overall 5-year survival rate in our study was 59.8% and in patients with conservative treatment alone 79.3%. Our findings thus corroborate the observations by Augsburger et al and Gündüz et al 8 9. They analysed patients with extraocular spread undergoing 125-iodine plaque therapy in eight and 17 patients respectively.…”

Section: Discussionsupporting

confidence: 92%

“…Augsburger et al and Gündüz et al suggested that the survival for enucleated patients and for patients with eye-conserving treatment is similar if the tumour characteristics are comparable 8 9. In our cohort, the tumour diameter was similar in the different treatment groups, but patients with a tumour thickness of more than 7 mm were more likely to be enucleated.…”

Section: Discussionmentioning

confidence: 45%

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Uveal melanoma: management and outcome of patients with extraocular spread

Bellmann

Rouic

Lévy

et al. 2009

British Journal of Ophthalmology

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BACKGROUND Extraocular spread is thought to be a negative prognostic factor on the survival in patients with uveal melanoma. Enucleation was the standard treatment in these patients. Today, depending on the size of the tumour and the type of extraocular extension, eye-preserving irradiation treatments, such as proton beams or radioactive plaques, may be employed. METHODS 2256 patients were treated between 2000 and 2007 at the Institut Curie, Paris, France for a uveal melanoma. 67 patients (3.0%) presented an extraocular extension. A retrospective study was performed to evaluate the patients' outcomes with regard to tumour recurrence and survival. RESULTS Eye-conserving treatment was employed in 38 (52.8%) patients. Enucleation was performed in 29 (47.2%) patients. The median follow-up was 38 (range 7 to 79) months with an overall survival rate at 5 years of 40.4% in enucleated patients and 79.3% in the eye-conserving treatment group (protons n=19, iodine-125 plaque n=19) (p=0.01; Kaplan-Meier analysis). No tumour recurrence was observed in any group. The degree of extraocular spread as well as the clinical characteristics tumour location, retinal detachment, ciliary body involvement (p<0.01; chi(2) test) and tumour thickness (p=0.04; chi(2) test) influenced the choice of treatment. Age, tumour diameter, involvement of optic nerve, vitreous haemorrhage and the amount of pigment did not have any influence. CONCLUSIONS Tumour recurrence rates and survival rates were not adversely affected in patients receiving conservative eye treatment. This may thus represent a therapeutic option in certain patients with extraocular spread.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 45%

Uveal melanoma: management and outcome of patients with extraocular spread

Bellmann

Rouic

Lévy

et al. 2009

British Journal of Ophthalmology

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“…The risk of metastatic disease after enucleation for uveal melanoma with extrascleral extension approaches 66% [4]. However, plaque radiotherapy for selected patients with uveal melanomas with extrascleral extension may reduce the incidence of orbital tumor recurrence relative to similar cases treated with enucleation [5]. We report an unusual patient with the above findings and whose fellow eye was completely blind.…”

Section: Introductionmentioning

confidence: 72%

Ciliary body melanoma with limited nodular extrascleral extension and diffuse iris-angle infiltration treated by whole anterior segment plaque radiotherapy

et al. 2007

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“…Minimal extrascleral extension can be treated by brachytherapy [4]. Moderate extrascleral extension can be treated with enucleation and focal excision of orbital disease.…”

Section: Introductionmentioning

confidence: 99%

Selective Intra-Arterial Embolization for Advanced Extrascleral Uveal Melanoma

et al. 2017

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Purpose: To report a treatment approach for advanced extrascleral uveal melanoma. Methods: We performed clinical examination including magnetic resonance imaging, computed tomography, angiography, and histopathologic analysis. Case: A 49-year-old healthy woman presented with a 7-year history of an enlarging pigmented mass in her right orbit. Malignant melanoma was diagnosed after biopsy with immunohistochemical stains. Treatment included selective intra-arterial embolization. Results: A significant reduction in tumor burden was seen 3 months after intra-arterial embolization. No complications were associated with the treatment. Conclusion: Selective intra-arterial embolization may allow adequate palliative therapy in select cases of advanced extrascleral uveal melanoma.

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Plaque radiotherapy for choroidal and ciliochoroidal melanomas with limited nodular extrascleral extension

Cited by 17 publications

References 18 publications

Uveal melanoma: management and outcome of patients with extraocular spread

Uveal melanoma: management and outcome of patients with extraocular spread

Ciliary body melanoma with limited nodular extrascleral extension and diffuse iris-angle infiltration treated by whole anterior segment plaque radiotherapy

Selective Intra-Arterial Embolization for Advanced Extrascleral Uveal Melanoma

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