Plaque radiotherapy for anterior uveal melanomas

Abstract

The results of the present clinical study confirm the effectiveness of brachytherapy for iris and iridociliary melanomas, which implies that tumor is well locally controlled and radiation-related complications are moderate and curable. This method of local tumor destruction can be another alternative to enucleation in cases when local tumor excision cannot be performed.

High-Dose-Rate Yttrium-90 (90Y) Episcleral Plaque Brachytherapy for Iris and Iridociliary Melanoma

“…Examples of malignant tumors include choroidal melanoma, retinoblastoma, choroidal metastasis, conjunctival squamous carcinoma, and conjunctival melanoma. 24 , 25 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 In addition, benign posterior segment tumors such as choroidal hemangioma and retinal angioma, as well as neovascular macular degeneration, eccentric disciform degeneration, and polypoidal choroidal vasculopathy, have also been treated. 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 Perhaps, the most common use of Sr 90 /Y 90 treatment has been to prevent pterygium-related episcleral fibrovascular growths.…”

Yttrium-90 Episcleral Plaque Brachytherapy for Choroidal Melanoma

“…[1][2][3][4][5] In Europe and Russia, the dual beta-radiation plaque sources ruthenium-106/rhodium-106 and strontium-90/yttrium-90 were commercialized. [6][7][8][9][10][11][12] The ruthenium-106/rhodium-106 plaques were multiday low dose rate, while the British strontium-90/ yttrium-90 high-dose-rate sources were radiosimilar to the singular isotope yttrium-90 disc source described in the current case study. [13][14][15] A key difference, however, was that the previous dual-isotope high-dose-rate strontium-90/yttrium-90 source was embedded at the distal end of a steel shaft, in contrast to the Liberty Vision yttrium-90 disc (Liberty Vision Corp), which is more like a seed and can be inserted into a clinical applicator.…”

Palladium-103 plaque therapy for multifocal iris melanoma: Radiation of the entire anterior segment of the eye

“…[2][3][4] Iris melanoma treatments include local surgical excision, radiation therapy, and enucleation. [1][2][3][4][5][6][7][8][9][10][11] While the primary goal is removal or destruction of the tumor, the evolving trends have been toward eye and vision preservation. Treatment depends on tumor size and location.…”

“…Larger non-resectable melanomas are more likely managed with irradiation or enucleation. [4][5][6][7][8][9] In 1952, Lloyd and Ellis 10 inserted radioactive tantalum wires into the eye to treat small iris melanoma as an alternative to enucleation. Since that report, multiple forms of episcleral radioactive plaque or external beam radiation therapy have evolved.…”

“…Since that report, multiple forms of episcleral radioactive plaque or external beam radiation therapy have evolved. [6][7][8][9] Radiation has been found to be an eye-and vision-sparing alternative to resection and enucleation.…”