Plaque-Phase Mycosis Fungoides Treated with Photodynamic Therapy: Results from 12 Patients

Photodynamic therapy with methyl-aminolevulinic acid for paucilesional mycosis fungoides: A prospective open study and review of the literature

“…[7][8][9][10][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] In total, 68 patients with MF have been treated with PDT in the literature. The first cases were reported in 1994 25,26 and until 2006, the 5-aminolevulinic acid photosensitizer was used.…”

“…[4][5][6] There are a few publications reporting the efficacy of photodynamic therapy (PDT) in MF, however they involve small samples and are difficult to compare because of a lack of technical standardization. [7][8][9][10] In total, 68 patients with MF treated with PDT have been reported. Two different photosensitizers have been used: 5-aminolevulinic acid and the methylaminolevulinic acid (MAL), and the number of PDT sessions, time interval between 2 sessions, duration of the occlusive photosensitizer application, and illumination duration can be highly variable.…”

Photodynamic Therapy in Mycosis Fungoides

“…13 Pain during the illumination appears to be very variable between patients, 27 and excellent tolerance was reported in the studies that used MAL rather than ALA as the photosensitizer. 27,28 Erythema and edema are common in the treated plaques, but scabs and erosions are rare. When they do appear, they typically resolve in 2 to 3 weeks.…”

“…Mild pigmentary changes, most commonly hyperpigmentation, or hair loss may develop in lesions with a complete response. 27,28 …”

“…28 The fluorescence decreases as the clinical response develops, and disappears in lesions once a complete response has been achieved. Diagnostic fluorescence therefore appears to be a useful tool for monitoring treatment, though there are no studies to clarify whether it is superior to clinical evaluation.…”