Plaque-based sub-blistering dosimetry: Reaching PASI-75 after two treatments with 308-nm excimer laser in a generalized psoriasis patient

Debbaneh, Maya; Levin, Ethan; Rodriguez, Robert Sanchez; Leon, Argentina; Koo, John; Rosenblum, Michael D.

doi:10.3109/09546634.2013.879094

Cited by 18 publications

(14 citation statements)

References 10 publications

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“…Studies have revealed that 308 nm excimer laser can significantly reduce the level of TnF-α in lesions (101), thereby promoting Mc function. Various studies reported that the expression of il-4, TnF-α and other inflammatory cytokines was downregulated after topical application of tacrolimus in lesions of vitiligo (102,103).…”

Section: Post-inflammatory Hyperpigmentations and Hypopigmentations Cmentioning

confidence: 99%

Roles of inflammation factors in melanogenesis (Review)

Chen

et al. 2020

Mol Med Report

113

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Section: Post-inflammatory Hyperpigmentations and Hypopigmentations Cmentioning

confidence: 99%

Roles of inflammation factors in melanogenesis (Review)

Chen

et al. 2020

Mol Med Report

113

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“…In a single-center pilot study, patients with greater than 10% but less than 30% body surface area involvement (moderate to severe psoriasis) were treated with excimer laser twice weekly for 12 weeks for a total of 24 treatment sessions. Fifty-four percent achieved PASI-75 and 83% achieved PASI-50, which was maintained without further treatment for 6 months 32 . However, the downside to treating moderate to severe psoriasis is the long duration required per session to treat a large body surface area, which may not be feasible in many dermatology office settings.…”

Section: Recent Advancesmentioning

confidence: 88%

“…It typically takes 5 to 10 treatments of incremental dose increase just to reach the ideal maximum dose of the plaque. A recent study has attempted to develop a new dosing protocol called “plaque-based sub-blistering dosimetry”, in which the patient’s psoriatic plaque, rather than uninvolved skin, is tested with incrementally increasing doses to determine the dose at which blistering is observed 32 . The patients then are treated just below that dose.…”

Section: Recent Advancesmentioning

confidence: 99%

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Recent advances in phototherapy for psoriasis

2016

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Phototherapy involves repeated exposure of the skin to ultraviolet light to treat various inflammatory skin conditions such as psoriasis. Recent studies have identified specific immunologic effects of phototherapy that may underlie phototherapy efficacy. Furthermore, recent advancements have been made in developing safe and effective targeted phototherapy modalities for difficult-to-treat areas such as scalp psoriasis. Targeted phototherapy in the form of the excimer laser holds potential for more aggressive, effective treatment and long-lasting remission of psoriasis. Phototherapy is now also used successfully with biologic agents as combination therapy to treat recalcitrant psoriasis. Therefore, though one of the oldest therapeutic modalities for psoriasis, phototherapy remains a mainstay treatment with promise for further advancement.

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“… 1 Furthermore, the excimer laser has the ability to target difficult to reach areas and administer site-specific dosing. 16 Also, it can operate with the ability to change the energy level (in millijoules) delivered during treatment. Few adverse reactions have been reported, and they are consistent with adverse reactions associated with other forms of phototherapy including erythema, blistering, hyperpigmentation, and hypopigmentation ( Figure 3 ).…”

Section: Safetymentioning

confidence: 99%

Excimer laser for the treatment of psoriasis: safety, efficacy, and patient acceptability

Abrouk¹,

Levin²,

Brodsky³

et al. 2016

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IntroductionThe 308 nm excimer laser is a widely used device throughout the field of dermatology for many diseases including psoriasis. Although the laser has demonstrated clinical efficacy, there is a lack of literature outlining the safety, efficacy, and patient acceptability of the excimer laser.MethodsA literature search on PubMed was used with combinations of the terms “excimer”, “excimer laser”, “308 nm”, “psoriasis”, “protocol”, “safety”, “efficacy”, acceptability”, “side effects”, and “dose”. The search results were included if they contained information pertaining to excimer laser and psoriasis treatment and description of the safety, efficacy, and patient acceptability of the treatment.ResultsThe 308 nm excimer laser is generally safe and well tolerated with minimal side effects including erythema, blistering, and pigmentary changes. It has a range of efficacies depending on the protocol used with several different treatment protocols, including the induration protocol, the minimal erythema dose protocol, and the newer minimal blistering dose protocol.ConclusionAlthough the excimer laser is not a first-line treatment, it remains an excellent treatment option for psoriasis patients and has been demonstrated to be an effective treatment with little to no side effects.

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Plaque-based sub-blistering dosimetry: Reaching PASI-75 after two treatments with 308-nm excimer laser in a generalized psoriasis patient

Abstract: This case demonstrates using a more aggressive dosing protocol determined by plaque testing is well-tolerated and can lead to excellent clearance with minimal side effects and comorbidity.

Cited by 18 publications

References 10 publications

Roles of inflammation factors in melanogenesis (Review)

Roles of inflammation factors in melanogenesis (Review)

Recent advances in phototherapy for psoriasis

Excimer laser for the treatment of psoriasis: safety, efficacy, and patient acceptability

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