Plaque-associated endogenous IgG and its impact on immunohistochemical detection of mouse monoclonal IgG antibodies in mouse models of Alzheimer’s disease
Shogo Ito,
Kenta Yamauchi,
Hiroshi Hama
et al.
Abstract:Experimental studies for Alzheimer's disease (AD) have largely depended on transgenic mice with β-amyloidosis. Here, we report plaque-associated endogenous immunoglobulin G (PA-IgG) and its impact on indirect immunohistochemical detection of mouse monoclonal IgG antibodies (Ms monoclonal IgG Abs) in the brain of AD mouse models. Immunostaining for Ms IgG in AD mouse models demonstrated endogenous IgG in the brain parenchyma accumulated on microglia associated with amyloid β (Aβ) plaques and/or Aβ plaques thems… Show more
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