“…In 2003, the major US and European pharmaceutical companies invested more than US$33 billion in R&D, at a higher R&D-to-sales ratio than virtually any other industry, including chemicals, automobiles, electronics, aerospace, and computers (PhRMA, 2004). However, while R&D processes last up to 13 years, only one of 5,000 product-ideas is launched on the market (Pfeiffer, 2000), and only one out of 10,000 substances becomes a marketable product (Völker, 2001). In addition, only three out of ten drugs that reach the market generate revenues that meet or exceed average R&D costs, and the 20 percent of products with the highest returns generate 70 percent of total returns F according to a study by Duke University economists (Reuters, 2002).…”