Plants with a reputation against snakebite

Martz, Walter

doi:10.1016/0041-0101(92)90429-9

Cited by 128 publications

(85 citation statements)

References 21 publications

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“…In this regard, plant extracts have become an attractive research material as a complement to the antiserum therapy (Martz, 1992;Mors et al, 2000). In the present study nine promising plant extracts that inhibited B. asper`s venom PLA 2 s with none cytotoxic effect were identified.…”

Section: Discussionmentioning

confidence: 93%

Correlation of the inhibitory activity of phospholipase A2 snake venom and the antioxidant activity of Colombian plant extracts

Pereañez¹,

Lobo-Echeverri²,

Rojano³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:Veneno de cobra continua a ser um problema importante de saúde em muitos países da América Latina. Apesar dos avanços na terapia antiveneno, os efeitos locais causados por fosfolipases A 2 miotóxica (PLA 2 ) presentes no veneno, ainda persistem. Em busca de alternativas para antagonizar a atividade da PLA 2 do veneno de Bothrops asper, foram selecionados 36 extratos pertencentes a dezessete famílias de plantas vasculares e briófitas. Uma inibição significativa da atividade enzimática de PLA 2 presente no veneno de B. asper foi observada em onze extratos. Além disso, a atividade antioxidante dos extratos foi avaliada. Os resultados evidenciaram uma correlação estatisticamente significativa entre os extratos com ação inibitória contra a PLA 2 e aqueles com atividade antioxidante. Também, a quantidade de fenóis foi avaliada e foi encontrada uma relação entre a atividade biológica e a presença dessas substâncias. Nove extratos foram testados contra uma fração do veneno rico em PLA 2 básica (Fx-V B. asper), resultando em um efeito inibitório na atividade desta fração da PLA 2 na faixa de 30-80%. Esta atividade foi apoiada pela inibição que esses extratos apresentaram na citotoxicidade causada pelo Fx-V B. asper sobre mioblastos C2C12 de músculo esquelético de murino. Os resultados podem indicar a minimização dos esforços na busca de inibidores da PLA 2 , com foco nas amostras com propriedades antioxidantes conhecidas.Unitermos: fosfolipase A 2 , veneno de cobra, Bothrops asper, extratos de plantas, antioxidantes, DPPH.ABSTRACT: Snakebite continues to be a significant health problem in many countries of Latin America. Even though, there has been an improvement in the antivenom therapy, the local effects caused by myotoxic phospholipases A 2 (PLA 2 ) present in the venoms, still persist. In search for alternatives to antagonize the PLA 2 activity of Bothrops asper's venom, 36 extracts belonging to seventeen families of vascular plants and bryophytes were screened. A significant inhibition of the enzymatic activity of PLA 2 present in B. asper's whole venom was seen in eleven of these extracts. In addition, the antioxidant activity of all the extracts was evaluated. The results evidenced a significant statistical correlation between extracts with an inhibitory effect against PLA 2 and those with an antioxidant activity. Moreover, the amount of phenols was quantified finding a relationship between the bioactivity and the presence of these compounds. Nine extracts were screened against a fraction of the venom rich in basic PLA 2 (Fx-V B. asper), exhibiting an inhibitory effect on PLA 2 activity of this fraction in a range of 30-80%. This activity was supported by the inhibition that these extracts presented on the cytotoxicity caused by Fx-V B. asper on murine skeletal muscle C2C12 myoblasts. The results obtained, could point to minimize efforts in the search of PLA 2 inhibitors by focusing in samples with known antioxidant properties.

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Section: Discussionmentioning

confidence: 93%

Correlation of the inhibitory activity of phospholipase A2 snake venom and the antioxidant activity of Colombian plant extracts

Pereañez¹,

Lobo-Echeverri²,

Rojano³

et al. 2010

Rev. bras. farmacogn.

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“…In many countries, plant extracts have been traditionally used in the treatment of snake bite poisoning (Martz 1992). Water extract of C. sylvestris leaves shows great inhibitory effects on the toxic, enzymatic, hemorrhagic and anticoagulant activities exhibited by various venoms, particularly against those belonging to the PLA 2 I (Phospholipase A 2 ) (Elapidae Family), II (Viperidae Family) e III (bee) types (Borges et al 2000(Borges et al , 2001.…”

Section: Anti-ophidian Activitymentioning

confidence: 99%

Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review

Ferreira

Costa-Lotufo

Moraes

et al. 2011

An. Acad. Bras. Ciênc.

103

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Folk uses and scientific investigations have highlighted the importance of Casearia sylvestris extracts and their relevant bioactive potential. The aim of this work was to review the pharmacological properties of C. sylvestris, emphasizing its anti-ulcer, anti-inflammatory, anti-ophidian and antitumor potentialities. Ethanolic extracts and essential oil of their leaves have antiulcerogenic activity and reduce gastric volume without altering the stomach pH, which corroborates their consumption on gastrointestinal disorders. Leaf water extracts show phospholipase A 2 inhibitory activity that prevents damage effects on the muscular tissue after toxin inoculation. This antiphospholipasic action is probably related to the use as an anti-inflammatory, proposing a pharmacological blockage similar to that obtained with non-steroidal anti-inflammatory drugs on arachidonic acid and cyclooxygenase pathways. Bioguided-assay fractionations lead to the identification of secondary metabolites, especially the clerodane diterpenes casearins (A-X) and casearvestrins (A-C), compounds with a remarkable cytotoxic and antitumor action. Therefore, the C. sylvestris shrub holds a known worldwide pharmacological arsenal by its extensive folk utilization, exciting searches for new molecules and a better comprehension about biological properties.

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“…Numerous researches are reported that shows the utilization of traditional medicinal plants for the treatment of snake bite poisoning. A plethora of medicinal plants is reported that possess the potential to combat the effect of snake venom [32]. According to numerous investigations, the presence of several essential phytoconstituents in these medicinal plants is responsible for an effective role in snakebite envenomation.…”

Section: Resultsmentioning

confidence: 99%

Molecular Docking Studies of Snake Venom Serine Protease of Sharp-Nosed Pit Viper With Hesperetin

Panda¹,

Ehsan

2018

Asian J Pharm Clin Res

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Objective: The management of snake bite envenomation is a global challenge affecting millions of people. Immunotherapy is still regarded as the treatment of choice; however, their subsequent adverse effects restrict their potential use for therapy against snake venom poisoning. In recent years, more attention has been given to the exploration of indigenous medicinal plants for their outstanding benefits for the treatment of several diseases and disorders, including snake venom poisoning. Hesperetin is a naturally occurring compound derived from a flavanone glycoside, hesperidin and is obtained from various citrus fruits. It is known to possess significant inhibitory activity against snake venom serine proteases. The aim of our present study was to investigate the significant inhibitory action of hesperetin on thrombin-like serine protease from sharp-nosed pit viper (Deinagkistrodon acutus) snake venom. Methods:We have employed molecular docking analysis by implementing the state-of-the-art docking program to validate the hypothesis of the prospective inhibitory properties of hesperetin on thrombin-like serine proteases of snake venom. AutoDock 4.2, InterProSurf, MGLTools, and MTiAutoDock were utilized for the molecular docking analysis of thrombin-like serine protease obtained from the snake venom of sharp-nosed pit viper with the natural compound hesperetin. Results:The results generated from in silico based approach reveals the significant inhibitory role of hesperetin against thrombin-like snake venom proteases, which might lead to the drug designing of the inhibitors of snake venom serine proteases. Conclusion:The implementation of molecular docking analysis by the employment of state-of-the-art docking program supports the potential of inhibitory activity of naturally obtained hesperetin compound on thrombin-like serine proteases of snake venom. The generated in silico results suggests that the novel structure hesperetin -flavanone might act as a potent inhibitor of thrombin-like snake venom proteases, and unlocks the possibilities for designing drugs of the inhibitors of snake venom serine proteases. Moreover, the investigation of the novel compound obtained from natural sources for their inhibitory activity against snake venom serine proteases would lead to the discovery of newer inhibitory compound from a highly uninvestigated research arena.

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Plants with a reputation against snakebite

Cited by 128 publications

References 21 publications

Correlation of the inhibitory activity of phospholipase A2 snake venom and the antioxidant activity of Colombian plant extracts

Correlation of the inhibitory activity of phospholipase A2 snake venom and the antioxidant activity of Colombian plant extracts

Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review

Molecular Docking Studies of Snake Venom Serine Protease of Sharp-Nosed Pit Viper With Hesperetin

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