Plants Used in the Treatment of Diabetes

Howes, Melanie-Jayne; Simmonds, Monique S. J.

doi:10.1201/9781420019001.ch2

Cited by 7 publications

(3 citation statements)

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“…The concepts of structural similarity and CS, which are ubiquitous in medicinal chemistry, are finding a place in other chemically related sciences such as materials science and engineering [185]. A question that now arises is how can we develop procedures and algorithms that exploit these concepts to facilitate the discovery of new drugs and bioactive agents?…”

Section: Exploring Cssmentioning

confidence: 99%

Foodinformatics

2014

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Section: Exploring Cssmentioning

confidence: 99%

Foodinformatics

2014

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“…Many herbal medicines are used for the treatment of diabetes, and the most widely-used modern antidiabetic medicine (metformin) is derived from guanidine and galegine, active compounds of the Western herbal remedy Galega officinalis (Simmonds and Howes, 2006). Moringa oleifera Lam.…”

Section: Introductionmentioning

confidence: 99%

Moringa Oleifera Leaf Powder for Type 2 Diabetes: A Pilot Clinical Trial

Sissoko

Diarra

Nientao

et al. 2023

Afr J Tradit Complement Altern Med

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Background: Moringa oleifera Lam. (Moringaceae) leaves are commonly used for diabetes in Mali. This pilot clinical study aimed to evaluate its effect on post-prandial blood glucose in preparation for a larger trial. Methods: Diabetic patients and non-diabetic healthy volunteers (35 each) were asked to fast for 13 hours on three occasions. Blood glucose was measured before and after eating 100g of white bread (at 30, 60, 90, 120, 150 and 180 minutes). On their second and third study visits, they were given 1g and 2g respectively, of M. oleifera leaf powder, 30 minutes after eating the bread. The mean paired reduction in blood glucose at each time interval and the incremental area under the curve were calculated. Results: Ingestion of Moringa powder had no effect on blood glucose in non-diabetic participants, but in diabetic patients, it lowered blood glucose at 90 minutes. There was a trend towards lower incremental area under the curve when diabetic patients took 2g of Moringa. No side-effects were reported by any participant. Conclusions: Moringa oleifera leaf powder reduced post-prandial glycaemia in diabetic patients. A larger study is needed to define the optimal dose and to assess whether this translates into longer-term benefits.

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“…The World Health Organization specialist team on diabetes has listed one of its recommendations that traditional methods of treatment for diabetes should be further investigated. [5] From thousands of year's natural products is one best alternative medicine for many diseases. [6] In the past 200 years, there is tremendous research has been developed in the field natural product drug discovery.…”

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confidence: 99%

Identification of New Antidiabetic Agents Targeting Glut4 Protein Using in Silico Analysis

Jayaraman¹

2018

IJGP

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Objective: Diabetes mellitus is a metabolic syndrome that constitutes a major health problem. It is estimated that 246 million people worldwide have diabetes and that 380 million people will be afflicted with diabetes by 2025. In addition, 3.8 million people die each year from diabetes. Natural products offer an advanced starting point in the search for highly specific and potent modulators of bimolecular function as well as novel drugs. In the present study, GLUT4 protein which plays a significant role in protecting β-cells from damage was selected as potential target. Materials and Methods: Three-dimensional structure of GLUT4 protein was build using modeller9v9.19. Modeled structure was validated through structure analysis verification server. With the purpose of identifying, the new potential drugs against GLUT4 protein molecular docking studies of 20 natural compounds were carried out using AutoDock. Results: The modeled structure has 87.9% residues in the core region. Results of docking studies clearly showed that good binding interactions of the ligand with both the targets at very low energy level. Conclusion: Based on the docking energy value, H-bond interaction the compounds hesperidin, fisetin, eriodictyol, wogonin, and chrysin was selected as the most potent compounds for GLUT4 protein. Hence, this present study suggests the consideration of these compounds for further in vitro and in vivo studies for its development as antidiabetic drugs.

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Plants Used in the Treatment of Diabetes

Cited by 7 publications

References 0 publications

Foodinformatics

Foodinformatics

Moringa Oleifera Leaf Powder for Type 2 Diabetes: A Pilot Clinical Trial

Identification of New Antidiabetic Agents Targeting Glut4 Protein Using in Silico Analysis

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