Plants of Haiti used as antifertility agents

Weniger, Bernard; Haag–Berrurier, M.; Anton, Robert

doi:10.1016/0378-8741(82)90072-1

Cited by 59 publications

(32 citation statements)

References 11 publications

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“…The bulb of this plant has been used as a folk medicine for coronary vasodilating, 1) prothrombin decreasing, 2) antifertility, 3) and woundhealing activities. 4) Previous phytochemical studies on the bulb of E. americana have resulted in the isolation of various types of naphthoquinones and anthraquinones.…”

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confidence: 99%

Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production

Han

Min

Nam

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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A new naphthoquinone, (؊)-3-[2-(acetyloxy)propyl]-2-hydroxy-8-methoxy-1,4-naphthoquinone (1) was isolated from the bulb of Eleutherine americana MERR. et HEYNE (Iridaceae) together with two known compounds, eleutherinol (6) and 1,5-dihydroxy-3-methylanthraquinone (7) which were found in this species for the first time. The other known compounds, (؊)-isoeleutherin (2), (؉)-eleutherin (3), (؊)-hongconin (4), and (؉)-dihydroeleutherinol (5) which were reported previously from this species, were also isolated in the present study. Compounds 2-6 exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 lipopolysaccharide-activated mouse macrophage cells with IC 50 values of 7.7, 11.4, 19.8, 21.7, and 34.4 m mM, respectively, whereas the other two compounds, 1 and 7, were inactive. The structure of compound 1 was elucidated by spectroscopic data analysis including 1D and 2D NMR experiments.

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confidence: 99%

Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production

Han

Min

Nam

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Eleutherol (3) has been isolated from the bulbs of Eleutherine bulbosa (Alves et al 2003;Gallo et al 2010). Some populations use this plant as a vermifuge (Schultes and Raffauf 1990), for intestinal disorders (Lin et al 2002) and as an abortive and antifertility agent (Weniger et al 1982). It is also the first time that this compound has been isolated from the bulbs of C. paludosa and, to the best of our knowledge, the first time its antiproliferative activity is reported.…”

Section: Discussionmentioning

confidence: 95%

Antiproliferative effect of extracts and pyranonaphthoquinones obtained from Cipura paludosa bulbs

Campos

Vendramini–Costa

Fiorito

et al. 2015

Pharmaceutical Biology

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Context: Cipura paludosa Aubl. (Iridaceae) is widely used in folk medicine to treat several ailments. Experimental studies have confirmed its anti-inflammatory, antinociceptive, and neuroprotective effects.Objective: This study evaluates the possible antiproliferative potential of the crude methanol extract and three isolated compounds from the bulbs of C. paludosa. Materials and methods: Phytochemical analysis was carried out by conventional chromatographic techniques, and the resulting compounds were identified by NMR 1 H and 13 C. The antiproliferative activity was analysed using the sulforhodamine B assay. Results: Crude methanol extract of C. paludosa bulbs showed GI 50 values of between 1.6 and 30.8 mg/mL. The naphthoquinone derivatives (eleutherine, isoeleutherine, and eleutherol) isolated from the bulbs of C. paludosa exhibited promising cytotoxicity against several human tumour cell lines, especially the two main compounds, eleutherine and isoeleutherine, against glioma and breast cancer cell lines, with TGI values of between 2.6 and 13.8 mg/mL. Conclusion: Cipura paludosa bulbs produce active principles with relevant antiproliferative potential, such as naphthoquinone derivatives, identified as eleutherine, isoeleutherine, and eleutherol. This is the first report indicating C. paludosa with antiproliferative potential. ARTICLE HISTORY

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“…It includes around 180 species that occur throughout the tropics and are widespread in the Americas, Africa, Asia, Malaysia, Australia and islands of the Pacific Ocean (1). At least 16 Casearia species have shown biological activity such as cytotoxic [C. arborea; C. grayi; C. grewiifolia; C. lucida; C. multinervosa; C. nigrescens; C. obliqua (2)(3)(4)(5)(6)(7)(8)]; antifungal [C. decandra (9)]; antidiabetic [C. esculenta (10)]; immunomodulatory [C. guianensis (11)]; antifertility [C. ilicifolia (12)]; antiophidian [C. mariquitensis (13)]; antitumor [C. membranacea (14)]; genotoxic [C. tomentosa (15)]; and antioxidant actions [C. velutina (16)]. The most studied among them is Casearia sylvestris Sw. that has shown several biological activities, including antitumor, antiulcer, analgesic, anti-inflammatory, cytotoxic, antifungal, anticancer, anti-snake and bee venom PLA 2 , genotoxic, trypanocidal, enzyme inhibitory, antihyperlipidemic and antibothropic properties (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

“…After 15 minutes, the absorbance of samples was read at 420 nm, considering a blank sample containing 80% methanol (8 mL) and 5% AlCl 3 (2 mL). The percentage of flavonoids (%) was calculated from a standard curve of quercetin (0,4,8,12, and 16 µg/mL) prepared with methanol. …”

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confidence: 99%

Bothrops jararacussu venom-induced neuromuscular blockade inhibited by Casearia gossypiosperma Briquet hydroalcoholic extract

Camargo¹,

Nazato²,

Silva³

et al. 2010

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:The hydroalcoholic extract of Casearia gossypiosperma Briquet (Flacourtiaceae) was standardized for the first time through quality control procedures including pharmacognostic methods, fingerprint chromatograms, defined amounts of marker substances and physicochemical characteristics. The pharmacological activity of C. gossypiosperma (Cg) hydroalcoholic extract was assayed by a traditional in vitro test, which involved irreversible neuromuscular blockade induced by Bothrops jararacussu (Bjssu) venom (60 μg/mL) in mouse phrenic nerve-diaphragm preparations. Bjssu venom blocked muscle activity for 26 (± 2.0) minutes (n = 6). Cg extract (0.1 mg/mL) induced changes on the baseline muscle activity without impairing the muscle function and inhibited 87.6% (± 1.8) (n = 6) of the Bjssu venom-induced blockade. Both flavonoids (0.624 g%) and polyphenols (4.63 g%) from the extract were spectrophotometrically quantified. Therefore, the present study confirms the antibothropic activity of Cg extract, supporting the ethnomedical use of Casearia sp. in the treatment of snakebite victims.Key words: antibothropic extract, Bothrops jararacussu, Casearia gossypiosperma Briquet, snake venoms. pharmacologically assessed for the first time. Original PaPer The Journal of Venomous Animals and Toxins including Tropical DiseasesIn vivo myotoxic effects and in vitro irreversible neuromuscular blockade effects of crude venom from the snake Bothrops jararacussu are well known pharmacological methods used to study drugs showing antivenom properties (29,30). Thus, the aim of the present study was to verify the capability of Casearia gossypiosperma hydroalcoholic extract to neutralize the neuromuscular blockade induced by Bothrops jararacussu venom. MATERIALS AND METHODS Plant Material and ExtractionLeaves from an adult C. gossypiosperma Briquet (Cg) tree were collected from the herbarium at the Higher School of Agriculture Luiz de Queiroz (ESALQ) of the University of São Paulo, Piracicaba, São Paulo, Brazil, in January 2006; the species was previously identified in 1988 (protocol IAC 38115). Cg leaves were dried at 35°C to 40°C for 24 hours. The dried leaves were then powdered, ground in a mill, macerated (200 g, during five days) in 2 L of 70% ethanol and the suspension was percolated (under protection against light) at 20 drops/minute, resulting in a 10% (m/v) hydroalcoholic extract. Quality Control Assays of the Medicinal Plants Ash and humidity testsTo observe elementary physical and chemical characteristics, Cg powder was subjected to ash and humidity tests (31). Briefly, 100 g of the specimen powder were placed in six calibrated melting pots, which were warmed until total carbonization of the powders. The melting pots were kept at 650°C and the ashes were then weighed. Results are expressed as grams of ashes/100 g of sample. The humidity test was performed by placing 1 g of specimen powder in six calibrated porcelain capsules, which were heated at 105ºC during four hours and then weighed. Thin Layer Chromatography (TLC)Aliquots...

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Plants of Haiti used as antifertility agents

Cited by 59 publications

References 11 publications

Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production

Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production

Antiproliferative effect of extracts and pyranonaphthoquinones obtained from Cipura paludosa bulbs

Bothrops jararacussu venom-induced neuromuscular blockade inhibited by Casearia gossypiosperma Briquet hydroalcoholic extract

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