Silver
has no biological role, and it is particularly toxic to
lower organisms. Although several silver formulations employed in
medicine in the past century are prescribed and sold to treat certain
medical conditions, most of the compounds, including those showing
outstanding properties as antimicrobial or anticancer agents, are
still in early stages of assessment, that is, in vitro studies,
and may not make it to clinical trials. Unlike other heavy metals,
there is no evidence that silver is a cumulative poison, but its levels
can build up in the body tissues after prolonged exposure leading
to undesired effects. In this review, we deal with the journey of
silver in medicine going from the alternative or do-it-yourself drug
to scientific evidence related to its uses. The many controversies
push scientists to move toward a more comprehensive understanding
of the mechanisms involved.