Plants as Sources of Antimalarial Drugs. Part 31Eurycoma longifolia

Chan, Kit‐Lam; O’Neill, Melanie J.; Phillipson, J. David; Warhurst, David C.

doi:10.1055/s-2007-969091

Cited by 116 publications

(72 citation statements)

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“…[3][4][5][6][7][8][9][10][11][12] It is a popular herb used by many local races of Malaysia and mainly used as aphrodisiac, antipyretic and anti-malarial remedy. [39] Not surprisingly, Jah Hut people often use it as an aphrodisiac remedy.…”

Section: Discussionmentioning

confidence: 99%

“…This is not the only source of income, but also an extension anti-hyperglycemic, anti-malarial, antiproliferative, anti-schistosomal, anxiolytic and aphrodisiac activities are found in both in vivo and in vitro studies. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Jah Hut people often use M. citrifolia to treat boils by topical application of leaves or fruits. This coincides with pharmacological validation, since boils (impetigo, folliculitis, furuncles, or carbuncles) are often caused by Staphylococcus aureus; M. citrifolia possess anti-bacterial properties to counter it.…”

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confidence: 99%

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Ethnobotanical study of medicinal plants used by the Jah Hut peoples in Malaysia

Lin¹

2005

Indian J Med Sci

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CONTEXT: An ethnobotanical study was carried out among the Jah Hut people who live in the central part of peninsular Malaysia. MATERIALS AND METHODS: The information on the medicinal plants was obtained from interview with a traditional medicinal man. The traditional uses and remedies were documented. The literature searches were carried out for the evaluation on the current status of investigations on these plants. RESULTS: In this study, we present 16 species of plants, which are commonly used among the Jah Hut people to cure some common diseases. DISCUSSIONS: This study is important to preserve the knowledge of medicinal plants used by Jah Hut people. The surveys of phytopharmacological literatures of these plants have great pharmacological and ethnobotanical significance.

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Section: Discussionmentioning

confidence: 99%

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Ethnobotanical study of medicinal plants used by the Jah Hut peoples in Malaysia

Lin¹

2005

Indian J Med Sci

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“…E. longifolia is available commercially as capsules of raw root powder, capsules of root water extract, mixed with other aphrodisiac herbs, or as additive with tea and coffee [7]. Various bioactive compounds have been identified in E. longifolia such as 9-hydroxycanthin-6-one, 9-hydroxycanthin-6-one noxide, 9-methoxycanthin-6-one, 9-methoxycanthin-6-one n-oxide, β-carboline-1-propionic acid, β-7-methoxycarboline-1-propionic acid, eurycomanol, eurycomanol-2-O-β-D-glucoside, 13-β-l,8dihydroeurycomanol, 14,15-dihydroxyklaineanone and eurycomanone [8][9][10][11]. Eurycomanone is the main compound in E. longifolia.…”

Section: Introductionmentioning

confidence: 99%

Reverse Phase High Performance Liquid Chromatography for the Quantification of Eurycomanone in Eurycoma longifolia Jack (Simaroubaceae) Extracts and their Commercial Products

Khari¹,

Aisha²,

Ismail³

2014

Trop. J. Pharm Res

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Purpose: To develop a reverse phase high performance liquid chromatography (HPLC) method for the determination of eurycomanone in E. longifolia Jack (Simaroubaceae) aqueous root extract and their commercial products. Methods: Analysis was carried out using reverse phase HPLC at 254 nm and a gradient mobile phase that comprised of acetonitrile and 0.1 % formic acid. Flow rate was 1 ml/min and separation was done using Phenomenex, Luna C18 column (150 mm x 4.6 mm, 5 µm). Validation tests were performed in order to demonstrate the linearity, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ) of the method. Results: Linearity was in the range 0.1 -50.0 µg/ml (R 2 = 0.9999). Precision, as relative standard deviation of retention time and peak area of reference compound was < 0.14, and < 2.75 %, respectively. Accuracy, as percent recovery of eurycomanone, was in the range 94.2 -99.8 % while LOD and LOQ were 0.293 ± 0.100 and 0.887 ± 0.300 µg/ml, respectively. Eurycomanone concentration in E. longifolia extracts and commercial products was 0.89 -3.28, and 0.07 -0.16 %, respectively. Analysis of the ethanol extract and chloroform sub-extract showed high resolution of > 10 peaks, which indicate the suitability of the method for the analysis of extracts prepared in organic solvents as well. Conclusion:The proposed method shows good linearity, precision, accuracy and high sensitivity. The method can be applied in the routine quantification of eurycomanone for quality control of E. longifolia extracts and commercial products.

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“…This tree has achieved considerable attention from the public for its medicinal properties and is used traditionally as a blood coagulant for complications during childbirth, as a treatment for dysentery, and as an aphrodisiac, among other applications. Extracts from E. longifolia also contain biologically active compounds with antiplasmodial activity (Chan et al, 1986). Increased harvesting of wild-grown trees for their medicinal use has led to rapid thinning of natural populations and a potential loss of genetic diversity in this species.…”

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Genetic Diversity of Eurycoma longifolia Inferred from Single Nucleotide Polymorphisms,

et al. 2003

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Eurycoma longifolia Jack. is a treelet that grows in the forests of Southeast Asia and is widely used throughout the region because of its reported medicinal properties. Widespread harvesting of wild-grown trees has led to rapid thinning of natural populations, causing a potential decrease in genetic diversity amongE. longifolia. Suitable genetic markers would be very useful for propagation and breeding programs to support conservation of this species, although no such markers currently exist. To meet this need, we have applied a genome complexity reduction strategy to identify a series of single nucleotide polymorphisms (SNPs) within the genomes of several E.longifolia accessions. We have found that the occurrence of these SNPs reflects the geographic origins of individual plants and can distinguish different natural populations. This work demonstrates the rapid development of molecular genetic markers in species for which little or no genomic sequence information is available. The SNP markers that we have developed in this study will also be useful for identifying genetic fingerprints that correlate with other properties of E. longifolia, such as high regenerability or the appearance of bioactive metabolites.

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Plants as Sources of Antimalarial Drugs. Part 3¹Eurycoma longifolia

Cited by 116 publications

References 5 publications

Ethnobotanical study of medicinal plants used by the Jah Hut peoples in Malaysia

Ethnobotanical study of medicinal plants used by the Jah Hut peoples in Malaysia

Reverse Phase High Performance Liquid Chromatography for the Quantification of Eurycomanone in <i>Eurycoma longifolia</i> Jack (Simaroubaceae) Extracts and their Commercial Products

Genetic Diversity of Eurycoma longifolia Inferred from Single Nucleotide Polymorphisms,

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