Plantar Verrucae in Patients with Human Immunodeficiency Virus

Abstract

Several previous studies have yielded data showing that plantar and other cutaneous verrucae follow a more aggressive course in patients infected with human immunodeficiency virus (HIV) than in uninfected individuals. A pilot study was undertaken to identify trends in a sample population that would support this characterization of plantar verrucae in HIV+ patients and to determine whether there are differences in treatment response between HIV+ and HIV- patients. The results show that the HIV+ patients in the study presented with a significantly greater number and total area of lesions than did the HIV- patients. Furthermore, the HIV+ patients experienced a greater frequency of recurrence of their lesions following treatment with surgical curettage. These findings should provide the foundation for other extensive, multicenter studies to further characterize the treatment response of these lesions in HIV+ patients and to develop effective guidelines for their management.

Different skin wart types, different human papillomavirus types? A narrative review

“…Similar to common warts, immunocompromised patients have been observed to have a significantly greater number of plantar warts as well as longer duration, higher treatment resistance, and greater frequency of recurrence (50,51). King et al (50) have confirmed that HPV2, HP27, and HPV57 can also frequently be detected in plantar warts of HIV-positive patients.…”

Multiplexed PCR genotyping of HPVs from plantaris verrucae

“…Verrucae are found in all age groups, are frequently associated with immunosuppression and late stages of HIV infection, and tend to reoccur following treatment (Barbosa, 1998;Porro et al, 2003;Rodrigues et al, 2001;Whitaker et al, 2001). Improved DNA extraction methodology from thick, keratinized tissue (Herber and Herold, 1998;Pfannenstein et al, 2000;Walsh et al, 1991) and consensus nested or multiplexed PCR (Berkhout et al, 1995;Gravitt and Manos, 1992) have provided means to obtain incidence and prevalence data.…”