Plantar flexor strength at different knee positions in older and young males and females

Ema, Ryoichi; Kawaguchi, Emi; Suzuki, Momoka; Akagi, Ryota

doi:10.1016/j.exger.2020.111148

Cited by 7 publications

(7 citation statements)

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“…Given the heterogeneity in RFD between elderly males and females, 25 analysis was performed separately for each sex. Due to the imbalance in baseline gender distribution between cases and controls, CKD patients and controls were balanced using propensity-score matching to ensure the assumption of sphericity (Figure S1) was being met.…”

Section: Discussionmentioning

confidence: 99%

“…35 Changes in tendon stiffness can induce RFD discrepancies, but no such change has been demonstrated in CKD patients, presumably because the rate of force transmission through the tendon is extremely fast, requiring a considerably large change in the tendon structure to significantly disrupt RFD. 16,25 Human type-II muscle fibres are faster than type-I fibres. In CKD patients, advanced glycation end products might induce a transition towards fast-to-low-speed muscle fibre type.…”

Section: Discussionmentioning

confidence: 99%

“…Changes in tendon stiffness can induce RFD discrepancies, but no such change has been demonstrated in CKD patients, presumably because the rate of force transmission through the tendon is extremely fast, requiring a considerably large change in the tendon structure to significantly disrupt RFD 16,25 …”

Section: Discussionmentioning

confidence: 99%

“…24 Explosive force generation is sensitive to age-related changes and differs between males and females because of differences in neuromuscular functions and structures. 25 It also depends on health status. D'Emanuele et al (2021) validated the quantification of explosive force (i.e., assessment of the RFD rather than MVF) to assess neuromuscular fatigability.…”

Section: Introductionmentioning

confidence: 99%

“…Explosive force generation is sensitive to age‐related changes and differs between males and females because of differences in neuromuscular functions and structures 25 . It also depends on health status.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the rate of force development reveals high neuromuscular fatigability in elderly patients with chronic kidney disease

Chatrenet

Piccoli

Audebrand

et al. 2023

J cachexia sarcopenia muscle

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BackgroundChronic kidney disease (CKD) induces muscle wasting and a reduction in the maximum voluntary force (MVF). Little is known about the neuromuscular fatigability in CKD patients, defined as the reduction of muscle force capacities during exercise. Neuromuscular fatigability is a crucial physical parameter of the daily living. The quantification of explosive force has been shown to be a sensitive means to assess neuromuscular fatigability. Thus, our study used explosive force estimates to assess neuromuscular fatigability in elderly CKD patients.MethodsInclusion criteria for CKD patients were age ≥ 60 years old and glomerular filtration rate (GFR) < 45 mL/min/1.73 m2 not on dialysis, and those for controls were GFR > 60 mL/min/1.73 m2, age and diabetes matched. The fatigability protocol focused on a handgrip task coupled with surface electromyography (sEMG). Scalars were extracted from the rate of force development (RFD): absolute and normalized time periods (50, 75, 100, 150 and 200 ms, RFD50, RFD75, RFD100, RFD150 and RFD200, respectively), peak RFD (RFDpeak in absolute; NRFDpeak normalized), time‐to‐peak RFD (t‐RFDpeak) and the relative force at RFDpeak (MVF‐RFDpeak). A statistical parametric mapping approach was performed on the force, impulse and RFD–time curves. The integrated sEMG with time at 0–30, 0–50, 0–100 and 0–200 ms time intervals relative to onset of sEMG activity was extracted and groups were compared separately for each sex.ResultsThe cohort of 159 individuals had a median age of 69 (9IQR) years and body mass index was 27.6 (6.2IQR) kg/m2. Propensity‐score‐matched groups balanced CKD patients and controls by gender with 66 males and 34 females. In scalar analysis, CKD patients manifested a higher decrement than controls in the early phase of contraction, regarding the NRFDpeak (P = 0.009; η2p = 0.034) and RFD75 and RFD100 (for both P < 0.001; η2p = 0.068 and 0.064). The one‐dimensional analysis confirmed that CKD males manifest higher and delayed neuromuscular fatigability, especially before 100 ms from onset of contraction. sEMG was lower in CKD patients than controls in the 0–100 ms (at rest: P = 0.049, Cohen's d = 0.458) and 0–200 ms (at rest: P = 0.016, Cohen's d = 0.496; during exercise: P = 0.006, Cohen's d = 0.421) time windows. Controls showed greater decrease of sEMG than CKD patients in the 0–30 ms (P = 0.020, Cohen's d = 0.533) and 0–50 ms (P = 0.010, Cohen's d = 0.640) time windows. As opposite to females, males showed almost the same differences between groups.ConclusionsOur study is the first to show that CKD patients have higher fatigability than controls, which may be associated with an impaired motor‐unit recruitment, highlighting a neural drive disturbance with CKD. Further studies are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%