Plantar basal cell carcinoma in a patient with xeroderma pigmentosum: importance of dermoscopy for early diagnosis of nonpigmented skin cancer

Basal Cell Carcinoma Arising from Xeroderma Pigmentosum: A Case Report and an Immunohistochemical Study

“…XP is a rare autosomal recessive, cancer-prone genodermatosis characterized by a defect in the repair of DNA damage caused by UVR, resulting in a high risk in the development of cutaneous malignancies, including BCCs, squamous cell carcinomas and melanomas on sun-exposed areas [19, 20, 21]. Histological criteria of XP are characterized as follows: hyperkeratosis, chronic inflammation in the upper dermis and hyperpigmentation in the early stage, and basophilic degeneration of the collagen and solar elastosis in the upper dermis in the later stage [2].…”

Basal cell carcinoma of the palm: An unusual presentation of a common tumour

“…1,2 In this setting, most of these cases have been described in patients affected by predisposing syndromes such as Gorlin-Goltz or xeroderma pigmentosum, but isolated sporadic cases are extremely rare. [1][2][3] The latter have been related to previous trauma, scarring, arsenic exposure or irradiation, 2,3 but cases without any associated factor are exceptional. A Caucasian woman in her 60s presented for evaluation of a plaque on her right palm.…”

“…Dermoscopic findings do not differ from BCC in other locations; and blue-grey ovoid nests, leaf-like structures or dotted vessels can aid in the diagnosis. 1,3 Interruption of the dermatoglyphics has been described as a characteristic feature. 3 The main clinical differential diagnoses include squamous cell carcinoma (SCC), Bowen disease and eccrine poroma.…”

“…1,3 Interruption of the dermatoglyphics has been described as a characteristic feature. 3 The main clinical differential diagnoses include squamous cell carcinoma (SCC), Bowen disease and eccrine poroma. Eccrine poroma presents histopathologically as cuboid cells with…”

Melanoma‐associated retinopathy: Photopsias as a first sign of melanoma progression?

“…These theories are supported by isolated reports of improved survival in MAR patients with metastatic disease and autoantibodies targeting bipolar cells. [3][4][5] Among the few treatments that have been found to improve MAR symptoms are intravitreal corticosteroid injections, plasmapheresis and intravenous corticosteroids or immunoglobulins. 5 Our patient's symptoms were improved by repeated subtenon triamcinolone injections.…”